Histopathological change

No histopathological changes in midgut epithelium general paralysis or rise in blood pH Germination of spores and multiplication of vegetative bacilli... 

In vivo, patients treated with AZT develop a mitochondrial myopathy with mitochondrial DNA depletion, deficiency of cytochrome c oxidase (complex IV), intracellular fat accumulation, high lactate production and marked phosphocreatine depletion (Lewis and Dalakas 1995 Dalakas 2001). Clinically, the patient presents with fatigue, myalgia, muscle weakness, wasting and elevated serum creatine kinase. Muscle biopsy shows ragged red fibers , the characteristic histopathologic changes of mitochondrial myopathy, cansed by subsarcolemmal accumulation of mitochondria (Lewis and Dalakas 1995). 

Histopathological changes in the gastrointestinal tract were not observed in rats exposed to 600 ppm trichloroethylene 7 hours/day, 5 days/week for 104 weeks (Maltoni et al. 1988). 

Histopathological changes in the lungs have not been observed in other intermediate- and chronic-duration studies of rats or mice orally exposed to trichloroethylene (Maltoni et al. 1986 NCI 1976 NTP 1988, 1990). The maximum doses used in these studies were 3,000 mg/kg/day for an intermediate-duration study in mice (NTP 1990), and 1,097 mg/kg/day for a chronic-duration study in rats (NCI 1976). 

Adrenal gland weights were not affected in rats treated by gavage with 1,500 mg/kg/day trichloroethylene in com oil for 14 days (Berman et al. 1995). Histopathological changes in endocrine glands (thyroid, parathyroid, pancreas, adrenals, pituitary) have not been observed in rats or mice exposed by gavage to trichloroethylene in oil for intermediate or chronic durations (Maltoni et al. 1986 NCI 1976 NIP 1988, 1990). 

In a chronic oral study in rats, observation of squinting and red discharge from the eyes were reported more frequently in trichloroethylene exposed rats as the study progressed (NCI 1976). Histopathological changes in the eyes were not reported in rats following chronic inhalation exposure (Maltoni et al. 1988) or in rats or mice following chronic oral exposure (Maltoni et al. 1986 NCI 1976 NTP 1988). Based on the limited data. 

Zimmerman, L.E. and Silverstein, A.M. (1959). Experimental ocular hypersensitivity histopathological changes observed in rabbits receiving a single injection of antigen into the vitreous. Am. J. Ophthalmol. 48, 447-465. 

Renal Effects. Animal studies indicate that degenerative changes in the kidneys may result from acute inhalation exposure to 241 Am. Repeated intraperitoneal injection of241 Am resulted in histopathologic changes in the kidneys of rats. 

Respiratory Effects. Inhalation exposure of dogs to 241 Am resulted in respiratory insufficiency and pneumonia as well as histopathologic changes in the lungs. Inhalation exposure of rats resulted in radiation pneumonitis. 

No histopathological changes in endocrine tissues (adrenal glands and thyroid) were noted in rabbits receiving <480 mg/kg/day Cellulube 220 for < 14 days (Carpenter et al. 1959), or in rats receiving <350 mg/kg/day tributyl phosphate for 18 weeks (Laham et al. 1985). 

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