Acid phosphatase inducible

Figure 5 Model of phosphorus (P) deficiency-induced physiological changes associated with the release of P-mobilizing root exudates in cluster roots of white lupin. Solid lines indicate stimulation and dotted lines inhibition of biochemical reaction sequences or mclaholic pathways in response to P deliciency. For a detailed description see Sec. 4.1. Abbreviations SS = sucrose synthase FK = fructokinase PGM = phosphoglueomutase PEP = phosphoenol pyruvate PE PC = PEP-carboxylase MDH = malate dehydrogenase ME = malic enzyme CS = citrate synthase PDC = pyruvate decarboxylase ALDH — alcohol dehydrogenase E-4-P = erythrosc-4-phosphate DAMP = dihydraxyaceConephos-phate APase = acid phosphatase.

Kim MS, Day CJ, Selinger Cl, Magno CL, Stephens SR, Morrison NA. MCP-1-induced human osteoclast-like cells are tartrate-resistant acid phosphatase, NFATcl, and calcitonin receptor-positive but require receptor activator of NFkap-paB ligand for bone resorption. J Biol Chem 2006 281(2) 1274-1285. 

Phosphate starvation inducible acid phosphatases in higher plants... 

Enhancement of POD-capacity and appearance of new isoforms is generally considered as an important criterion for senescence (Hazell and Murray, 1982). Lee et al. (1976a) suggested that the cadmium-induced capacity increase of POD and several hydrolytic enzymes (ribonuclease, deoxyribonuclease, acid phosphatase) in Glycine max should constitute an accelerated senescence response. In Zea mays, an induction of leaf acid phosphatase was also reported for toxic concentrations of lead (Maier, 1978 b). 

A18. Axline, S. G., Isozymes of acid phosphatase in normal and Calmette-Gu4rin bacillus-induced rabbit alveolar macrophages. J. Exp. Med. 128, 1031-1048 (1968). 

The co-administration of M. oleifera seed powder with arsenic protects animals from arsenic induced oxidative stress and reduce body arsenic burden (49). Exposure of rats to arsenie (2.5 mg/kg, intraperitoneally for 6 weeks) increases the levels of tissue reaetive oxygen species (ROS), metallothionein (MT) and thiobarbitnrie aeid reaetive substance (TEARS) and is accompanied by a decrease in the aetivities in the antioxidant enzymes such as superoxide dismutase (SOD), eatalase and glutathione peroxidase (GPx). Also, Arsenic exposed mice exhibits hver injury as reflected by reduced acid phosphatase (AGP), alkaline phosphatase (ALP) and aspartate aminotransferase (AST) activities and altered heme synthesis pathway as shown by inhibited blood 8-aminolevulinic acid dehydratase (5-ALAD) activity. Co-administration of M. oleifera seed powder (250 and 500 mg/kg, orally) with arsenie significantly increases the activities of SOD, catalase, GPx with elevation in redueed GSH level in tissues (liver, kidney and brain). These ehanges are accompanied by approximately 57%, 64% and 17% decrease in blood ROS, liver metallothionein (MT) and lipid peroxidation respectively in animal eo-administered with M. oleifera and arsenic. There is a reduced uptake of arsenie in soft tissues (55% in blood, 65% in liver, 54% in kidneys and 34% in brain) following eo-administration of M. oleifera seed powder (particularly at the dose of 500 mg/kg). This points to the fact that administration of M. oleifera seed powder could be beneficial during chelation therapy with a thiol chelator (26). 

When the ODF/ODAR complex activates c-src to form a ruffled membrane, it also activates NFkB to activate the transcription factors that induce cathepsin K and acid phosphatase expression. Because ODF binds to ODAR/RANK, it is also known as the RANK ligand (RANKL). OCIF (OPG), the ODF decoy receptor, is RANK without its transmembrane and cytosolic domains. Thus OCIF = OPG and OPG ligand (OPGL) = RANKL = ODF. ODF, ODAR, and OCIF are related to TNFa or its receptor, TNFa family molecules (Table 10.1). 

Kai M, Wada I, Imai S, Sakane F, Kanoh H (1996) Identification and cDNA cloning of 35-kDa phosphatidic acid phosphatase (type 2) bound to plasma membranes. Polymerase chain reaction amplification of mouse H2O2-inducible hic53 clone yielded the cDNA encoding phosphatidic acid phosphatase. J Biol Chem 271 18931-18938... 

It was subsequently reported that, in the rabbit, burns at 80° C induced rises in all three groups of enzymes, namely, LDH and GOT, the cytoplasmic GPT, and the lysosomal enzymes acid phosphatase and 8-glucu-ronidase (L7). No change occurred at the time in the contralateral limb. The rabbit seems more sensitive in these respects than the cat. 

To clarify the mechanism of action of these diterpenoids on bone resorption, their effect on osteoclast-like cell formation was tested according to the method reported by Takahashi et al.[34]. As a result, both compounds dose-dependently inhibited PTH-induced tartrate resistant acid phosphatase-positive MNC formation. Especially, SDC showed complete inhbition at concentration over 0.1 pM. Next, the effect of SDB and SDC on resorbing activity of osteoclasts (pit forming activity of osteoclast-like cells) was assayed according to the method of Tamura et al. [35]. As indicated in Table 8, both compounds inhibited the pit-formation when osteoclasts obtained by the co-culture were placed on dentine slice in the presence of these compounds. Therefore, the inhibitory effect of... 

This acid induced impairment of development and reconciled with decreases found in uterine weight and its total protein contents. It prevented specific uterine alkaline phosphatase activity. On the otherhand, specific uterine acid phosphatase activity remained low on days 4 and 5 and increased significantly thereafter. It indicated that aristolic acid interferes with steroidal conditioning of the uterus and renders it hostile to ovum implantation. 

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