Polychlorinated biphenyls mixtures

Yadav JS, JF Quensen, JM Tiedje, CA Reddy (1995) Degradation of polychlorinated biphenyl mixtures (Aro-chlors 1242, 1254, 1260) by the white rot fungus Phanerochaete chrysosporium as evidenced by congener-specific analysis. Appl Environ Microbiol 61 2560-2565. 

Duinker, J.C., D.E. Schulz, and G. Petrik. 1988b. Multidimensional gas chromatography with electron capture detection for the determination of toxic congeners in polychlorinated biphenyl mixtures. Anal. Chem. 60 478-482. 

Quensen, J.F., III, M.A. Mousa, S.A. Boyd, B.J.T. Sanderson, K.L. Froese, and J.P. Giesy. 1998. Reduction of aryl hydrocarbon receptor-mediated activity of polychlorinated biphenyl mixtures due to anaerobic microbial dechlorination. Environ. Toxicol. Chem. 17 806-813. 

Table II demonstrates the effect of two polychlorinated biphenyl mixtures (Aroclors 1254 and 1242), a polybrominated biphenyl mixture (Firemaster BP6), phenobarbital and -naphtho-flavone on various hemoprotein P-450-mediated monooxygenase activities of rainbow trout hepatic microsomes.

Mayes BA, McConnell EE, Neal BH, et al Comparative carcinogenicity in Sprague-Dawley rats of the polychlorinated biphenyl mixtures Aroclors 1016, 1242, 1254, and 1260. Toxicol Sci M y.62-16, 1998... 

Quensen, J. F. Ill, Boyd, S. A. Tiedje, J. M. (1990). Dechlorination of four commercial polychlorinated biphenyl mixtures (Aroclors) by anaerobic microorganisms from sediments. Applied and Environmental Microbiology, 56, 2360-9-... 

A.S. Stack, S. Altaman-Hamamdzic, P.J. Morris, S.D. London and L. London, Polychlorinated biphenyls mixtures (Arocolors) inhibit LPS-induced murine splenocyte proliferation in vitro, Toxicology, 139 (1999) 137-154. 

Tas, A.C., DeVos, R.H. (1971) Characterization of four major compounds in a technical polychlorinated biphenyl mixture. Environ. Sci. Technol. 5, 1217. 

Intermediate-duration oral studies in rats have shown that high doses of DEHP can affect thyroid cell structure (e g., hypertrophy of Golgi apparatus, increases in lysosomes, dilation of the endoplasmic reticula, and increase in colloid droplets) and function (e.g., decrease levels of circulating T4) (Hinton et al. 1986 Poon et al. 1997 Price et al. 1987, 1988a). When large oral doses of 500 and 2,500 mg/kg/day DEHP were combined with dietary exposure to a compound which has similar effects on the thyroid (Aroclor 1254, a polychlorinated biphenyl mixture), there was an apparent additive effect of the two compounds on changes in thyroid cell structure and decreases in serum T3 and T4. At lower doses of DEHP (50 and 100 mg/kg/day) and Aroclor 1254 there were no additive effects apparent with the changes in cell structure or the levels of T3 and T4. 

Kodavanti PR, Ward TR. Differential effects of commercial polybrominated diphenyl ether and polychlorinated biphenyl mixtures on intracellular signaling in rat brain in vitro. Toxicol Sci. 2005 85 952-962. 

Concentrations of CMorinated Dibenzofurans (CDFs) in Commercial Polychlorinated Biphenyl Mixtures... 

Soecies (test system) End point Results Reference Polychlorinated biphenyl mixture... 

Synonym(s) PCB-1016 Polychlorinated biphenyl mixture with 41.5% chlorine PCB-1221 Polychlorinated biphenyl mixture with 21% chlorine PCB-1232 Polychlorinated biphenyl mixture with 32% chlorine PCB-1242 Polychlorinated biphenyl mixture with 41.5% chlorine PCB-1248 Polychlorinated biphenyl mixture with 48% chlorine... 

Albro PW, Corbett JT, SchroederJL. 1981. Quantitative characterization of polychlorinated biphenyl mixtures (Aroclors 1248,1254, and 1260) by gas chromatography using capillary columns. J Chromatogr 205 103-111. 

Barsotti DA, Van Miller JP. 1984. Accumulation of a commercial polychlorinated biphenyl mixture (Aroclor 1016) in adult Rhesus monkeys and their nursing infants. Toxicology 30 31-44. 

Beebe LE, Kim YE, Amin S, et al. 1993. Comparison of transplacental and neonatal initiation of mouse lung and liver tumors by A-nitrosodimethylamine (NDMA) and4-(methylnitrosamino)-l-(3-pyridyl)-l-butanone (NNK) and promotability by a polychlorinated biphenyls mixture (Aroclor 1254). Carcinogenesis 14(8) 1545-1548. 

Bleavins MR, Breslin WJ, Aulerich RJ, et al. 1984. Placental and mammary transfer of a polychlorinated biphenyl mixture (Aroclor 1254) in the European ferret (mustela putorius furo). Environ Toxicol Chem 3 637-644. 

Bruckner JV, Jiang WD, Brown JM, et al. 1977. The influence of ingestion of environmentally encountered levels of a commercial polychlorinated biphenyl mixture (Aroclor 1254) on drug metabolism in the rat. J Pharmacol Exp Ther 202 22-31. 

Gould JC, Cooper KR, Scanes CG. 1997. Effects of polychlorinated biphenyl mixtures and three specific congeners on growth and circulating growth-related hormones. Gen Comp Endocrinol 106(2) 221-30. 

Hansen LG, Byerly CS, Metcalf RL, et al. 1975. Effect of a polychlorinated biphenyl mixture on swine reproduction and tissue residues. Am J Vet Res 36 23-26. 

Harper N, Connor K, Steinberg M, et al. 1995. Immunosuppressive activity of polychlorinated biphenyl mixtures and congeners Nonadditive (antagonistic) interactions. Fundam Appl Toxicol 27 131-139. 

Kodavanti PRS, Ward TR, McKinney JD, et al. 1995. Increased [ H]phorbol ester binding in rat cerebellar granule cells by polychlorinated biphenyl mixtures and congeners Structure-activity relationships. Toxicol Appl Pharmacol 130 140-148. 

Mehlman MA, Tobin RB, Friend B, et al. 1975. The effects of a polychlorinated biphenyl mixture (aroclor 1254) on liver gluconeogenic enzymes of normal and alloxan-diabetic rats. Toxicology 5 89-95. 

Nath RG, Randerath E, Randerath K. 1991. Short-term effects of the tumor promoting polychlorinated biphenyl mixture, Aroclor 1254, on I-compounds in liver, kidney and lung DNA of male Sprague-Dawley rats. Toxicology 68 275-289. 

Quenson JF III, Boyd SA, Tiedje JM. 1990. Dechlorination of four commercial polychlorinated biphenyl mixtures (Aroclor) by anaerobic microoganisms from sediments. Appl Environ Microbiol 56(8) 2360-2369. 

Schulze-Stack A, Altman-Hamamdzic S, Morris PJ, et al. 1999. Polychlorinated biphenyl mixtures (Aroclors) inhibit EPS-induced murine splenocyte proliferation in vitro. Toxicology 139 137-154. 

Vos JG, Notenboom-Ram E. 1972. Comparative toxicity study of 2,4,5,2, 4, 5 -hexachlorobiphenyl and a polychlorinated biphenyl mixture in rabbits. Toxicol Appl Pharmacol 23 563-578. 

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