Plasma hypercholesterolemic

GARDNER c D, NEWELL K A, CHERiN R and HASKELL w L (2001) The effect of soy protein with or without isoflavones relative to milk protein on plasma lipids in hypercholesterolemic postmenopausal women. dm J Clin Nutr. 73 (4) 728-35. 

WANGEN K E, DUNCAN A M, XU x and KURZER M s (2001) Soy isoflavones improve plasma lipids in normocholesterolemic and mildly hypercholesterolemic postmenopausal women. Am J Clin Nutr. 73 (2) 225-31. 

LICHTENSTEIN A H, AUSMAN L M, CARRASCO W, GUALLEIRI L J, JENNER J L, ORDOVAS J M, NICOLOSI R J, GOLDIN B R, SCHAEFER E J (1994) Rice bran oil consumption and plasma lipid levels in moderately hypercholesterolemic humans. Arterioscleroses and Thrombosis, 14(4) 549-556. 

WESTSTRATE J A, MEIJER G w (1998) Plant sterol emiched margarine and reduction of plasma and total LDL-cholesterol concentrations in normocholesterolemic and mildly hypercholesterolemic sahjects.. Eur J Clin Nutr, 52(5) 334-43. 

A comprehensive, randomized, placebo-controlled trial of infused bolus L-arg and its enantiomer (D-arg) included healthy subjects, non-insulin dependent diabetics, hypertensive subjects, and normotensives with primary hypercholesterolemia [147]. A blood-pressure drop and an acute inhibition of ADP-induced aggregation in platelet-rich plasma were observed in all subjects after L-arg administration (<5 g). Both responses to L-arg infusion closely correlated in magnitude, were weaker in noninsulin dependent diabetics and hypercholesterolemics, and declined with increasing age. Notably, D-arg did not elicit any of the L-arg effects, which were reduced by some 70% when superimposed upon ongoing, nonselective NOS inhibition with infused L-N-monomethyl-arginine (L-NMMA). Since D-arg is not a NOS substrate, and L-NMMA is a substrate-competitive NOS inhibitor, the L-arg effects observed in this study were theorized to reflect a rise in vascular NO production by eNOS. In contrast, the inhibition of platelet aggregation observed in vitro after a 5 min L-arg infusion (160 mg total dose) into healthy subjects and patients with angiographic... 

G16. Ghiselli, G., Gaddi, A., Barozzi, G., Ciarrocchi, A., and Descovich, G., Plasma lipopro-tein(a) concentration in familial hypercholesterolemic patients without coronary artery disease. Metab., Clin. Exp. 41, 833-838 (1992). 

CN128 Olsson, G., A. M. Ostlund-Lindquist, G. Bondjers, O. Wiklund, and S. O. Olofsson. Quantification of plasma lipids and apolipoproteins in British Halflop rabbits. A comparison between normocholesterolemic rabbits, hypercholesterolemic rabbits (modified WHHL rabbits) and rabbits fed an atherogenic diet. Atherosclerosis... 

McIntosh G. H., J. Whyte, R. McArthur, and P. J. Nestel. Barley and wheat foods influence on plasma cholesterol concentrations in hypercholesterolemic men. Am J Clin Nutr 1991 53(5) 1205-1209. 

Inflammation is an important factor in the development of cardiovascular disease. Most clinical studies involving inflammation parameters have been relatively small. The Nurses Health Study involving 727 women was the largest study designed to determine the effects of n-3 fatty acids on biomarkers of inflammation and endothelium activation (Lopez-Garcia et al., 2004). They found an inverse association between ALA intake and plasma concentrations of C-reactive protein (a marker for inflammation), Interlukin-6, and E-selectin. Bemelmans et al. (2004) also found an inverse association between C-reactive protein and ALA intake in a randomized, double-blind placebo-controlled study involving 103 hypercholesterolemic subjects. 

Jimenez, M.A., Scarino, M.L., Vignolini, F., and Mengheri, E. 1990. Evidence that polyunsaturated lecithin induces a reduction in plasma cholesterol level and favorable changes in lipoprotein composition in hypercholesterolemic rats. J. Nutr. 120, 659-667. 

Wilson, T.A., Meservey, C.M., and Nicolosi, R.J. 1998. Soy lecithin reduces plasma lipoprotein cholesterol and early atherogenesis in hypercholesterolemic monkeys and hamsters Beyond linoleate. Atherosclerosis 140, 147-153. 

Total body irradiation, a routine preconditioning procedure for treatment of leukemia and aplastic anemia before bone marrow transplantation, decreased TAC of blood plasma by 36%, as estimated by cyclic voltammetry (C26). TAC was found to decrease by about 40% during chemotherapy of patients with various hematologic malignancies with busuflan, VP-16, and cyclophosphamide (D12). The controversial procedure of blood ozonation was reported to decrease blood plasma TAC by 20% (B17). Treatment of hypercholesterolemic patients with bezafibrate (600 mg/day) for 1 month decreased TAC of their blood serum (G16). Propofol anesthesia decreased TAC of blood plasma of patients by 9.5% this effect was caused by hemodilution because mean hemoglobin concentration of the blood decreased accordingly (S26). 

Gardner, C.D., Chatteijee, L.M., and Carlson, J.J. 2001. The effect of a garlic preparation on plasma lipid levels in moderately hypercholesterolemic adults. Atherosclerosis 154, 213—220. 

Weanling, Wistar and RICO (genetically hypercholesterolemic) rats were placed on manganese-deficient (0.12 pg Mn/g) or manganese-sufficient (100.12 pg Mn/g) diets. Plasma total, VLDL- and HDL-cholesterol levels, and liver cholesterol and lipid concentrations were not affected by the treatment used. These results suggest that dietary manganese deficiency does not result in significant alterations in cholesterol and lipid metabolism in the rat (8). 

Baba, S., Natsume, M., Yasuda, A., Nakamura, Y., Tamura, T., Osakabe, N., Kanegae, M., Kondo, K. (2007a). Plasma LDL and HDL cholesterol and oxidized LDL concentrations are altered in normo- and hypercholesterolemic humans after intake of different levels of cocoa powder. J. Nutr., 137, 1436-1441. 

Mabuchi, H., Nohara, A., Kobayashi, J., Kawashiri, M.A., Katsuda, S., Inazu, A., and Koizumi, J. (2007). Effects of CoQlO supplementation on plasma lipoprotein lipid, CoQlO and liver and muscle enzyme levels in hypercholesterolemic patients treated with atorvastatin a randomized double-blind study. Atherosclerosis 195 el82-el89. 

Table 8.6 Effects of plant sterol or stanol treatment on plasma total (TC) and LDL-cholesterol concentrations in humans results of selected randomized, double-blind studies of healthy normocholesterolemic (NC) and hypercholesterolemic (HC) males (M) and females (F).

Jones, P.J. et al.. Cholesterol-lowering efficacy of a sitostanol-containing phytosterol mixture with a prudent diet in hyperlipidemic men. Am. J. Clin. Nutr., 69,1144,1999. Weststrate, J.A. and Meijer, G.W., Plant sterol-enriched margarines and reduction of plasma total- and LDL-cholesterol concentrations in normocholesterolemic and mildly hypercholesterolemic subjects, Eur. J. Clin. Nutr., 52, 334, 1998. 

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