Plasma cholesterol level

The most common side effect associated with the use of nelfinavir is diarrhea other less frequent adverse effects include elevated triglycerides and cholesterol plasma levels, nausea, rash and hyperglycemia. 

Dietary MUFA have been found to have several positive effects that include, in addition to lowering human LDL-cholesterol plasma levels, positive effects on lipoprotein oxidation, coagulation, and fibrinolysis (29). Low-fat, monounsaturate-rich diets reduce the susceptibility of low-density lipoproteins to peroxidation ex vivo (30). In hypercholesterolemic subjects, diets containing MUFA resulted in favorable alterations in the fatty acid composition and oxidative profile of LDL in hypercholesterolemic subjects that were characterized as an increase in lipid peroxide lag time and a decrease in lipid peroxide formation (30). In animal studies. 

Thyroid hormones regulate the turnover of carbohydrates, lipids, and proteins. They promote glucose absorption, hepatic and renal gluconeogenesis, hepatic glycogenolysis, and glucose utilization in muscle and adipose tissue (18). They increase de novo cholesterol synthesis but increase low-density lipoprotein degradation and cholesterol disposal even more, leading to a net decrease in total and in low-density lipoprotein cholesterol plasma levels (19). Thyroid hormones are anabolic when present at normal concentrations they then stimulate the expression of many key enzymes of metabolism. ... 

Slowing, K., Ganado, P., Sanz, M, Ruiz, E., and Tejerina, T. 2001. Study of garlic extracts and fi actions on cholesterol plasma levels and vascular reactivity in cholesterol-fed rats. J Nutr 131(3s) 994S-999S. 

Biochemical characteristics (plasma levels of alanine and aspartate transminases, alkaline phosphatase, triglycerides, cholesterol, urea, uric acid, allantoin, glucose, protein, albumin, sodium, potassium, calcium, magnesium, phosphorus urine levels of protein and glucose). 

A class of important pharmacological compounds that are the most effective drugs for lowering plasma levels of low-density-lipoprotein (LDL)-cholesterol. 

Contrary to LDL, high-density lipoproteins (HDL) prevent atherosclerosis, and therefore, their plasma levels inversely correlate with the risk of developing coronary artery disease. HDL antiatherogenic activity is apparently due to the removal of cholesterol from peripheral tissues and its transport to the liver for excretion. In addition, HDL acts as antioxidants, inhibiting copper- or endothelial cell-induced LDL oxidation [180], It was found that HDL lipids are oxidized easier than LDL lipids by peroxyl radicals [181]. HDL also protects LDL by the reduction of cholesteryl ester hydroperoxides to corresponding hydroperoxides. During this process, HDL specific methionine residues in apolipoproteins AI and All are oxidized [182]. 

Nuts Atherosclerosis Increase in ratio of monosaturated/saturated fatty acids which causes a decrease in the plasma level of LDL-cholesterol... 

Increased plasma HDL and HDL-2 subfraction concentrations, reduced LDL cholesterol concentration levels, increased triglyceride levels. 

The statins may lower the risk of CHD by decreasing inflammation, an important component of atherogene-sis. Lovastatin decreased elevated plasma levels of C-reactive protein, a marker for cellular inflammation, and acute coronary events in patients with relatively low plasma cholesterol levels. Recent studies also suggest that use of statins may decrease the risk of stroke, dementia, and Alzheimer s disease and may improve bone... 

However, very low plasma levels of HDL cholesterol are also found in patients with genetically disturbed metabolic pathways that are indirectly linked to HDL metabolism. For example, many patients with lipid storage diseases like Gaucher s disease (glucocerobrosidase deficiency, OMIM 230800-231000), Nieman-Pick disease types A or (sphingomyelinase deficiency, OMIM 257200 and 607616, respectively), Niemann-Pick disease type C (OMIM 257220), hypertriglyceridemia, or diabetes mellitus present with low HDL cholesterol [22]. 

FHBL (OMIM 107730) is a codominant disorder characterized by plasma levels of total cholesterol, LDL-cholesterol, triglycerides, and apoB below the fifth percentile of the distribution in the general population. FHBL is genetically heterogeneous it may be linked to the apoB gene. The best-characterized FHBL cases are those due... 

Cohen JC, Kiss RS, Pertsemlidis A, Marcel YL, McPherson R, Hobbs HH (2004) Multiple rare alleles contribute to low plasma levels of HDL cholesterol. Science 305 869-872... 

The major biochemical changes observed are a striking depletion of ATP, impaired protein synthesis, defective incorporation of amino acids, and the appearance of RNA and proteins containing the ethyl rather than the methyl group. The plasma levels of triglycerides, cholesterol, lipoprotein, and phospholipid are all decreased. 

Unlike other lipoproteins, HDL particles are assembled outside of cells from lipids and proteins, some of which may be donated from chylomicrons (see Fig. 21-1) or other lipoprotein particles. HDL has a higher protein content than other lipoproteins and is more heterogeneous. The major HDL protein is apolipoprotein A-I, but many HDL particles also contain A-jj 205,208-210 ancj apolipoproteins A-IV, D, and E may also be present. A low plasma level of HDL cholesterol is associated with a high risk of atherosclerosis.205 207... 

Cholesterol biosynthesis is also controlled by the plasma levels of low-density lipoproteins, which we discuss in the context of lipoprotein metabolism later in this chapter. 

The claimed body-building effect of the so-called anabolic compounds reflects their ability to promote muscular development, even beyond physiological limits, and this can bring with it cardiovascular complications. Surreptitious misuse by athletes remains a recurrent problem in professional sport (73) apart from the cardiovascular risks, one observes numerous physiological changes, including effects on plasma levels of enzymes, minerals and vitamins and reduced concentrations of HDL cholesterol (74). 

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