Pituitary cancer

Prosta.te Ca.ncer, Estrogen has an inhibitory effect on the prostate in addition to its suppression of gonadotropin secretion by the pituitary. The three- and five-year survival rates in prostate cancer patients with metastatic disease improved when treated with DES (7) alone or along with castration. However, DES does not improve the survival rates in patients whose carcinoma is confined to the prostate. Small doses of DES (1 mg/d) appear to retard prostate cancer growth and could reduce the cardiovascular complications associated with larger doses (5 mg/d) (135) (see... 

Pulmonary disease, small-cell lung cancer, head trauma, stroke, central nervous system infections, pituitary surgery, prolactinoma, severe nausea, psychiatric disease, and postoperative state... 

Nelson s syndrome A condition characterized by the aggressive growth of a pituitary tumor and hyperpigmentation of the skin. Neoadjuvant therapy Therapy given prior to the primary treatment. In cancer, it is usually given prior to surgery to make the surgical... 

Causes of organic ED include diseases that compromise vascular flow to the corpora cavernosum (e.g., peripheral vascular disease, arteriosclerosis, essential hypertension), impair nerve conduction to the brain (e.g., spinal cord injury, stroke), and are associated with hypogonadism (e.g., prostate or testicular cancer, hypothalamic or pituitary disorders). 

There has been some concern that the recently observed decline in sperm quality may be related to exposure to environmental estrogens (Sharpe and Skakkebaek, 1993) and at the same time there has been speculation that these estrogenic compounds may exert inhibitory effects against prostate cancer (Kurzer, 2002). Theoretically, exposure to high levels of dietary estrogens could alter the hypothalamic-pituitary-gonadal axis in men, but dietary studies to date have not shown such an hormonal effects. 

Singh NP, Panwar VK. (2006) Case report of a pituitary macroadenoma treated with artemether. Integr Cancer Ther 5 391-394. 

Pituitary TSH suppressants In the treatment or prevention of various types of euthyroid goiters, including thyroid nodules, subacute, or chronic lymphocytic thyroiditis (Hashimoto), multinodular goiter, and in the management of thyroid cancer (except liothyronine). 

Alvaro V, Touraine P, Raisman Vozari R, Bai-Grenier F, Birman P, Joubert D (1992) Protein kinase C activity and expression in normal and adenomatous human pituitaries. Int J Cancer 50 724-730... 

Glover D, Poland R (2002) Urinary cortisol and catecholamines in mothers of child cancer survivors with and without PTSD. Psychoneiu oendocrinology 27 805-819 Goeinjian AK, Pynoos RS, Steinberg Am, Endres D, Abraham K, Geffner ME, Fairbanks LA (2003) Hypothalamic-pituitary-adrenal activity amongArmenian adolescents with PTSD symptoms. J Trauma Stress 16 319-323... 

Buserelin (Suprefact) and leuprolide (Lupron) are peptide analogues of the hypothalamic hormone LH-RH (luteinizing hormone-releasing hormone). Chronic exposure of the pituitary to these agents abolishes gonadotropin release and results in markedly decreased estrogen and testosterone production by the gonads. Their major clinical use is in the palliative hormonal therapy of cancer of the prostate. 

The first cyclotron was built by Ernest O. Lawrence in 1932, and since 1938, cyclotrons have been used for patient treatment. In Berkeley, in 1954, the first human target irradiated with protons was the pituitary gland with the aim to suppress its function for slowing down the metastatic development of breast cancer. 

Thyrotropin stimulating hormone (TSH) Bovine pituitary Identification of thyroid cancer metastases in patients previously treated for thyroid cancer... 

Clifton, K.H. and Crowley, J.J. (1978). Effects of radiation type and dose and the rate of glucocorticoids, gonadectomy, and thyroidectomy in mammary tumor induction in mammotrophic-secreting pituitary tumor-grafted rats, Cancer Res. 38,1507. 

SHELLABARger, C.J. (1981). "Pituitary and steroid hormones in radiation-induced mammary tumors, page 339 in Hormones and Breast Cancer Banbury Report 8, Pike, M.C., Suteri, P.K., and Welch, C.W., Eds. (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York). 

A 67-year-old man with prostate cancer and an unsuspected pituitary macroadenoma developed a severe frontal headache, nausea and vomiting, and blindness within 12 hours of insertion of a goserelin implant (11). 

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