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Testosterone production

Oral testosterone products are also available for supplementation. Unfortunately, testosterone has poor oral bioavailability and undergoes extensive first-pass metabolism. Alkylated derivatives such as methyltestosterone and fluoxymesterone have been formulated to compensate for these problems, but this modification makes them considerably more hepatotoxic. This adverse effect makes oral replacement undesirable and this route of administration should not be used. [Pg.788]

FSH and hCG also find application in the treatment of male subfertility or related conditions. Both are administered to males exhibiting hypogonadotrophic hypogonadism to stimulate sperm synthesis and normal sexual function. hCG has found limited application in the treatment of prepubertal cryptorchidism (a condition characterized by failure of the testes to descend fully into the scrotum from the abdomen). The ability of this hormone to stimulate testosterone production also caught the attention of some athletes, and, as a result, the International Olympic Committee has banned its use. [Pg.320]

Isolated cells from adrenal and testes held in media containing 0.065, 0.65, or 6.5 mg/kg for 2 h No effect at lowest doses. High dose caused decreased survival of cells from both organs and reduced testosterone production 23... [Pg.207]

A dose-related depression in testosterone production at doses not producing any general toxic or significant cytotoxic action... [Pg.504]

Depressed testosterone production of Leydig cells at 20 mg/kg BW and higher normal histology... [Pg.504]

Forgacs, Z., K. Paksky, P. Lazar, and E. Tatrai. 1998. Effect of Ni2+ on the testosterone production of mouse primary Leydig cell culture. Jour. Toxicol. Environ. Health 55A 213-224. [Pg.522]

Testosterone products Transdermal patch (Testoderm TTS, Androderm, Testim) Testoderm (R) with or without adhesive) 5 mg patch applied to arm, back, or thigh every evening (patches 2.5, 4, 5, 6 mgf 6 mg applied to scrotal skin every evening... [Pg.40]

Increased prolactin levels are associated with blocking testosterone production from the testes depressed libido results. [Pg.950]

Dalterio S, Bartke A, Mayfield D. (1985a). Effects of delta 9-tetrahydrocannabinol on testosterone production in vitro influence of Ca++, Mg+-i-, or glucose. Life Sci. 37(15) 1425-33. [Pg.557]

Howdesheil KL, Wilson VS, Furr J, Lambright CR, Rider CV, Blystone CR, Hotchkiss AK, Gray LE (2008) A mixture of five phthalate esters inhibits fetal testicular testosterone production in the Sprague Dawiey rat in a cumulative, dose additive manner. Toxicol Sci 105 153-165... [Pg.296]

In the male, IGF-1 is synthesized by the Sertoli and Leydig cells of the testes. It also stimulates testosterone production by the Leydig cells, and promotes growth and maintenance of various additional testis cell types. [Pg.285]

Buserelin (Suprefact) and leuprolide (Lupron) are peptide analogues of the hypothalamic hormone LH-RH (luteinizing hormone-releasing hormone). Chronic exposure of the pituitary to these agents abolishes gonadotropin release and results in markedly decreased estrogen and testosterone production by the gonads. Their major clinical use is in the palliative hormonal therapy of cancer of the prostate. [Pg.650]

Leuprolide is a potent LH-RH agonist for the first several days to a few weeks after initiation of therapy, and therefore, it initially stimulates testicular and ovarian steroidogenesis. Because of this initial stimulation of testosterone production, it is recommended that patients with prostatic cancer be treated concurrently with leuprolide and the antiandrogen flutamide (discussed earlier). Leuprolide is generally well tolerated, with hot flashes being the most common side effect. [Pg.650]

Human prolactin is similar in structure to human growth hormone, and both are good lactogens. In women, prolactin acts with other hormones on the mammary gland during pregnancy to develop lactation and after birth to maintain it. Hyperprolactinemia causes impotence in men and amenorrhea and infertility in women. Chronically elevated levels of circulating prolactin are associated with suppression of 17-p-estradiol and testosterone production in the ovaries and testes. [Pg.679]

E) It preferentially blocks cortisol synthesis as opposed to testosterone production. [Pg.701]

A) A relatively constant level of testicular testosterone production... [Pg.732]

C. In adolescent males, testicular testosterone production dramatically rises from prepuberal levels and then declines into adulthood. However, with advancing adulthood there is a drop in the metabolic clearance rate of testosterone, increasing the length of time that testosterone remains in the serum. Evidence of a relatively constant level of serum testosterone is seen in the relative constant levels of urinary 17-ketosteroids, a metabolite of testosterone, from the second to the fifth decade of life. [Pg.733]

In all species, metabolism of testosterone leads to its biological deactivation. In sheep and cattle, this biological deactivation leads mainly to formation of epitestosterone, whereas in nonruminants it leads to androsterone, etiocholano-lone, and dehydroepiandrosterone (7-9). Residues of endogenous testosterone are usually highest in the kidneys of animals such as heifers witli a low testosterone production rate, and highest in fat of animals such as bulls, with a high production rate. [Pg.197]

Testosterone is available as oral testosterone undecano-ate, buccal testosterone, intramuscular testosterone esters, testosterone implants, and testosterone transdermal patches and gel. Proponents of transdermal testosterone products, such as gels and scrotal or non-scrotal dermal patches, claim that they have a good safety profile (101). Transdermal testosterone replacement certainly improves bone mass and lean body mass, reduces fat mass, and improves mood and sexual function. There are said to be no harmful effects on the prostate and lipids. Acne, polycythemia, and gynecomastia are stated to be less common with this form of therapy than with the intramuscular esters. To date these claims must be regarded with some reservations it is not at all clear that in equieffective doses the local or topical forms of administration dissociate wanted and unwanted effects. [Pg.145]

Testosterone production is governed by the hypothalamus- pituitary -testes -axis referred to hereafter as the "HPTA". The HPTA has a series of checks and balances all influenced by serum (the fluid part of the blood containing the active hormones which circulate through the body) levels of several hormones and pro-hormones. If testosterone production is too low, the testes signal the hypothalamus to release more leutenizing-... [Pg.7]


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See also in sourсe #XX -- [ Pg.6 , Pg.43 , Pg.435 , Pg.436 ]

See also in sourсe #XX -- [ Pg.272 ]

See also in sourсe #XX -- [ Pg.449 ]




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