Pharmaceutical preparation

The purity of a pharmaceutical preparation of sulfanilamide, C6H4N2O2S, can be determined by oxidizing the sulfur to SO2 and bubbling the SO2 through H2O2 to produce H2SO4. The acid is then titrated with a standard solution of NaOH to the bromothymol blue end point, where both of sulfuric acid s acidic protons have been neutralized. Calculate the purity of the preparation, given that a 0.5136-g sample required 48.13 mL of 0.1251 M NaOH. 

The analysis of a pharmaceutical preparation for pheniramine maleate and phenylephrine hydrochloride is described in this experiment. 

Let s use a simple example to develop the rationale behind a one-way ANOVA calculation. The data in Table 14.7 show the results obtained by several analysts in determining the purity of a single pharmaceutical preparation of sulfanilamide. Each column in this table lists the results obtained by an individual analyst. For convenience, entries in the table are represented by the symbol where i identifies the analyst and j indicates the replicate number thus 3 5 is the fifth replicate for the third analyst (and is equal to 94.24%). The variability in the results shown in Table 14.7 arises from two sources indeterminate errors associated with the analytical procedure that are experienced equally by all analysts, and systematic or determinate errors introduced by the analysts. 

Table 14.7 shows the results obtained by four analysts determining the purity of a pharmaceutical preparation of sulfanilamide. Determine if the difference in their results is significant at a = 0.05. If such a difference exists, estimate values... 

Reagent-grade urea is used in some pharmaceutical preparations. In these appHcations, urea must meet the purity specifications issued by the ACS. 

As predictable from the similarity of the properties of the two gums, quince seed gum is used in the appHcations described above for psyllium seed gum. Specific appHcations are in cosmetics and hair-setting lotions. It has also been used as an emulsifier and stabilizer in pharmaceutical preparations. 

Lactic acid is generally recognized as safe (GRAS) for multipurpose food use. Lactate salts such as calcium and sodium lactates and esters such as ethyl lactate used in pharmaceutical preparations are also considered safe and nontoxic (7). The U.S. Food and Dmg Administration fists lactic acid (all isomers) as GRAS and sets no limitations on its use in food other than current good manufacturing practice (46). 

Wintergreen Oil. Water distillation of the leaves of Gaultheriaprocumbens L. yields an oil which consists of essentially one chemical constituent, methyl saUcylate. Because of this, the oil has been almost totally replaced by the synthetic chemical. Natural oil of wintergreen [68917-75-9] is a pale yellow to pinkish colored mobile Hquid of intensely sweet-aromatic odor and flavor. The oil or its synthetic replacement find extensive use in pharmaceutical preparations, candy, toothpaste, industrial products, and in rootbeer flavor. In perfumery, it is used in fougnre or forest-type fragrances. 

Gelatinous boehmite, called alumina gel in commeicial use, is used in the piepaiation of adsorbents, desiccants (qv), catalysts, and catalyst supports (see Catalysts, SUPPORTBd). A significant amount is used in pharmaceutical preparations. 

Economic Aspects and Uses. Ammonium bromide is available as a dry technical grade or as 38 to 45% solutions. It is used to manufacture chemical Hitermediates, and Hi photographic chemicals it also has some flame retardant appHcations. In June 1991, its price was quoted as 2.66/kg. Ammonium iodide has limited use Hi photographic and pharmaceutical preparations. 

Water Treatment. Water and steam chemistry must be rigorously controlled to prevent deposition of impurities and corrosion of the steam cycle. Deposition on boiler tubing walls reduces heat transfer and can lead to overheating, creep, and eventual failure. Additionally, corrosion can develop under the deposits and lead to failure. If steam is used for chemical processes or as a heat-transfer medium for food and pharmaceutical preparation there are limitations on the additives that may be used. Steam purity requirements set the allowable impurity concentrations for the rest of most cycles. Once contaminants enter the steam, there is no practical way to remove them. Thus all purification must be carried out in the boiler or preboiler part of the cycle. The principal exception is in the case of nuclear steam generators, which require very pure water. These tend to provide steam that is considerably lower in most impurities than the turbine requires. A variety of water treatments are summarized in Table 5. Although the subtieties of water treatment in steam systems are beyond the scope of this article, uses of various additives maybe summarized as follows ... 

Sucralfate [54182-58-0] an aluminum salt of sucrose octasulfate, is used as an antacid and antiulcer medication (59). Bis- and tris-platinum complexes of sucrose show promise as antitumor agents (60). Sucrose monoesters are used in some pharmaceutical preparations (21). A sucrose polyester is under evaluation as a contrast agent for magnetic resonance imaging (mri) (61). Oral adrninistration of this substance opacifies the gastrointestinal tract and eliminates the need for purging prior to mri. 

Guaiol is valuable as a raw material for preparing guaiazulene (109), an antiinflammatory ia pharmaceutical preparations for skin cosmetics. Guaiol is also used as alow cost fixative ia perfumery. The acetate, guaiyl acetate [134-28-1/, is also useful ia perfumery. Bulnesol is not used as such but contributes to the fixative properties of guaicwood oil. The price of the oil ia 1995 was 9.90/kg (69). 

Potassium chlorate is used mainly in the manufacture of matches (qv) and pharmaceutical preparation. In pyrotechnics, chlorate salts may be mixed with certain organic compounds such as lactose to give a relatively cool flame, so that certain dyes may be incorporated in the mixture to give colored flares. 

Chloroform was used chiefly as an anesthetic and in pharmaceutical preparations immediately prior to World War II. However, these uses have been banned. Annual output in both the United States and the United Kingdom was between 900 and 1350 metric tons. During the war, chloroform production in the United States tripled, largely to meet the requirement for penicillin manufacture. Demand for chloroform continued to increase in the postwar period as its technical appHcations were extended. Consumption continues to increase at a comparatively rapid rate. Chloroform is now used primarily in the manufacture of HCFC-22, monochlorodifluoromethane, a refrigerant, and as a raw material for polytetrafluoroethylene plastics. 

The principal use of 1,1,2-trichloroethane is as a feedstock intermediate in the production of 1,1-dichloroethylene. 1,1,2-Trichloroethane is also used where its high solvency for chlorinated mbbers, etc, is needed, as a solvent for pharmaceutical preparation, and in the manufacture of electronic components. 

Pharmaceutical Preparations, Except Biologicals, 1975, Current Industrial Reports, Series MA-28G(75)-1, U.S. Bureau of the Census, Department of Commerce, Washington, D.C., 1976. 

Authors are designed row sensitive and selective test-systems for analysis of heavy metals, active chlorine, phenols, nitrates, nitrites, phosphate etc. for analysis of objects of an environment and for control of ions Ee contents in the technological solutions of KH PO, as well as for testing some of pharmacological psychotropic daigs alkaloids (including opiates), cannabis as well as pharmaceutical preparations of phenothiazines, barbiturates and 1,4-benzodiazepines series too. 

SPECTROPHOTOMETRIC DETERMINATION OF ATORVASTATIN AND FLUVASTATIN IN PHARMACEUTICAL PREPARATIONS AFTER DERIVATIZATION WITH 9-CHLOROMETHYLANTHRACENE... 

A simple, rapid, precise and economical High Performance Thin Layer Chromatographic (HPTLC) method has been developed and validated for determination of Alprazolam and Melatonine in its pharmaceutical preparation. It was performed on silica gel 60 Thin Layer... 

SpiessglanZ kermes, m. kermesite kermes mineral, -kbnig, m. regulus of antimony, -leber,/. livex of antimony, hepar antimonii. -metall, n. antimony, -mittel, n. antimonial remedy, -mohr, m. aethiops antimonialis (old pharmaceutical preparation of mercury and antimony sulfides). -ocker, m, antimony ocher, -oxyd,n. antimon> trioxide. -safran,... 

The combined ether extracts were washed with 5% aqueous sodium bicarbonate solution, dried over anhydrous sodium sulfate, and fractionally distilled in vacuo. The fraction boiling at about 145° to 150°C at the pressure of 0.5 mm of mercury, weighing 61 g and consisting of 1-methyl-5-allyl-5-(1-methyl-2-pentynyl) barbituric acid, was collected. The only distillate was substantially pure, and could be used as such In pharmaceutical preparation or a salt could be prepared therefrom according to the procedures disclosed hereinafter. On standing, the oil crystallized. The crystalline 1-methyl-5-allyl-5-( 1-methyl-2-pentynyl) barbituric acid melted at about 60° to 64°C after recrystallization from dilute ethanol. 

In certain direct steam-contact process applications (such as in food and beverage processing or pharmaceutical preparations) the use of amine-based products in steam and condensate systems is subject to legal restrictions. Also, the use of ammonia or amines may be dependent on the materials of construction employed or technical limitations (such as the risk of copper alloy corrosion). 

Other uses of thickening agents include pharmaceutical preparations, paper production, and oil well drilling fluids. This latter use is necessary because oil is obtained from rock that is porous. In order to remove the oil without altering the mechanical properties of the porous rock, viscous liquids ( drilling fluids ) are pumped into the rock to replace the oil. Among the substances that can be used for this purpose are thickened aqueous solutions of polymers such as poly(acrylic acid) or poly(acrylonitrile). 

JP59 029 652 (Nippon Kayaku Co. appl. 16.2.1984 J-prior. 10.8.1982). pharmaceutical preparations ... 

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