Sucrose octasulfate

Sucralfate [54182-58-0] an aluminum salt of sucrose octasulfate, is used as an antacid and antiulcer medication (59). Bis- and tris-platinum complexes of sucrose show promise as antitumor agents (60). Sucrose monoesters are used in some pharmaceutical preparations (21). A sucrose polyester is under evaluation as a contrast agent for magnetic resonance imaging (mri) (61). Oral adrninistration of this substance opacifies the gastrointestinal tract and eliminates the need for purging prior to mri. 

Kundu, A., Shikla, A. A., Barnthouse, K. A., Moore, J., and Cramer, S. M., Displacement chromatography of proteins using sucrose octasulfate, BioP-harm., 64, May 1997. 

Sucralfate is a nonabsorbable aluminum salt of sucrose octasulfate that has limited value and is not routinely recommended for treatment of GERD. 

Sucrose octasulfate (23, Structures 6) bound to FGF and was able to induce, like heparin, a conformational change in the peptide, but showed very low mitogenic activity for an F32 cell line. The basic aluminium salt of sucrose octasulfate, which is used as a drug (Sucralfate, Carafate) for the treatment of duodenal ulcers was claimed to exert part of its activity through the stabilization of FGF... 

Structures 6. Structure of a laminaro oligosaccharide and sucrose octasulfate... 

It is a basic aluminium salt of sucrose octasulfate. It polymerizes at pH < 4 to form a sticky, viscid yellow white gel which adheres to ulcer base. The gel acts as a strong mechanical barrier because of a strong... 

K. Ochi, Y. Watanabe, K. Okui, and M. Shindi, Crystalline salts of sucrose octasulfate, Chem. Pharm. Bull., 28 (1980) 638-641. 

D. B. Volkin, A. M. Verticelli, K. E. Marfia, C. J. Burke, H. Mach, and C. R. Middaugh, Sucralfate and soluble sucrose octasulfate bind and stabilize acidic fibroblast growth factor, Biochim. Biophys. Acta, 1203 (1993) 18-26. 

Waters Q-8HR (strong anion exchange, 8 /r particles) and Waters Q-40HR (strong anion exchange, 40 /r particles) Sucrose octasulfate /3-lactoglobulins A and B 42... 

Sucralfate, a basic aluminium salt of sucrose octasulfate, probably acts by binding to inflamed surfaces it is possible, however, that its binding properties are more generalized, and it has been used as an intra-alimentary phosphate-binding agent in uremic patients. 

Sucralfate is a topically active aluminum hydroxide salt of sucrose octasulfate. 

Tetra-O-sulfo- -D-fructofuranosyl cc-D-glucopyranoside tetrakis(hydrogen sulfate). Sucrose octasulfate [57680-56-5]... 

Sucrose 4 -(L-arabinos-2-yl phosphate), A-63 Sucrose monopalmitate, S-92 Sucrose monostearate, S-92 Sucrose octasulfate, S-94 Sucrose, S-92 -Sucrose, A-83 fl/tro-Sucrose, F-52 Sucrosetricarboxylic acid, S-93 Sucrosofate potassium, S-94 Sucrosofate, S-94 Sugammadex sodium, 0-1 Sugordomycin Did, C-154 Suleparoid sodium, H-4 Sulfatide, S-95 Sulfenosine, S-96 Sulfmosine, S-96... 

ID and 2D) of long-chain N-alkyl lactosylamines has been reported. All H- and C-resonances of potassium sucrose octasulfate have been assigned with the help of 2D and deuterium-induced differential-isotope-shift (DIDIS) n.m.r. methods. A H-n.m.r. study in D2O showed that 3 -ketolactose (11) crystallized from methanol as the hemiacetal 12 with an equatorial methoxy group. A 500 MHz H-n.m.r. investigation of methyl fl-cellobioside confirmed the presence of an intramolecular hydrogen bond between HO-3 and 0-5 in DMSO, but not in DjO or CDjOD. ... 

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