Pseudo-peptides

Rationalization of the results obtained in the substitution reactions prompted their application to topics of current interest, such as studies on the structures and biological activities of peptides, depsi-peptides, pseudo-peptides, or C2-symmetric... 

I 4 Peptide Nucleic Acid (PNA) A Pseudo-peptide with DNA-like Properties... 

Peter E. Nielsen (Ed.) Pseudo-peptides in Drug Discovery... 

This field has also inspired the development of a range of pseudo-peptides, that is polyamides composed of amino acids other than a-amino acids. These include for instance peptoids, /9-amino acid oligomers and also compounds such as peptide nucleic acids and DNA binding polyamides, all of which share the amide (peptide) chemistry with natural peptides. 

Chen R, Yue Z, Eccleston ME et al (2005) Modulation of cell membrane disruption by pH-responsive pseudo-peptides through grafting with hydrophilic side chains. J Control Release 108 63-72... 

By targeting nucleolin on the cell surface, HB-19 pseudo-peptides (Nisole et al, 2002a) inhibit HIV attachment to the cell surface of mammalian cells and subsequent viral entry, demonstrating that nucleolin could also be an interesting pharmaceutical target to prevent viral infection. 

Cousins, G. R. L. Poulsen, S.-A. Sanders, J. K. M. Dynamic combinatorial libraries of pseudo-peptide hydrazone macrocycles. Chem. Commun. 1999, 1575-1576. 

Scheme 9 Ugi-4CR + cyclization approaches to six-membered pseudo-peptidic scaffolds...

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