Lipids peptide-nucleic acids

Biologicals Lipids, peptides, nucleic acids, polysaccharides, viruses Vesicles, nanotubes, rings, nanoparticles, nanocapsules, nanospheres... 

MALDI-IM MS is useful for the separation of major groups of biomolecules such as lipids, peptides, nucleic acids, but it is also capable of separating different classes of molecules within a group, for example, phospholipids. Phospholipids are present in abundance in all biological membranes and represent over half the lipid content of the brain (18). The general structural... 

Alber S., Huang L., Watkins S., Li S. Lipid-mediated delivery of peptide nucleic acids to pulmonary endothelium. 

Epitopes for T lymphocytes comprise exclusively linear peptide sequences. T lymphocytes are unable to respond to carbohydrate, lipid or nucleic acid material and they only respond to peptide antigen when it is presented to the T lymphocyte by surface proteins on the plasma membrane of host cells. These surface proteins are termed major histocompatibility complex (MHC) proteins and can be subdivided into two main classes. MHC class I proteins are expressed on the surface of all nucleated host cell membranes and present peptide antigen to cytotoxic T lymphocytes. MHC class II proteins are expressed only on a more specialized group of cells termed antigen-presenting cells (APCs), and present peptide antigen to helper T lymphocytes. 

The general types of protein-protein interactions that occur in cells include receptor-ligand, enzyme-substrate, multimeric complex formations, structural scaffolds, and chaperones. However, proteins interact with more targets than just other proteins. Protein interactions can include protein-protein or protein-peptide, protein-DNA/RNA or protein-nucleic acid, protein-glycan or protein-carbohydrate, protein-lipid or protein-membrane, and protein-small molecule or protein-ligand. It is likely that every molecule within a cell has some kind of specific interaction with a protein. 

These basic concepts are followed by a section on the structure of the important biomolecules (pp. 34-87). This part of the book is arranged according to the different classes of metabolites. It discusses carbohydrates, lipids, amino acids, peptides and proteins, nucleotides, and nucleic acids. 

Fundamental building blocks (amino acids, carbohydrates, lipids, nucleotides), organic and inorganic prosthetic groups, biopolymers (nucleic acids, peptides/ proteins, polysaccharides), membranes. 

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