Somatostatin analog

Hofland LJ, Lamberts SWJ (1997) Somatostatin analogs and receptors. Diagnostic and therapeutic applications. Cancer Treat Res 89 365-382... 

Sun L., Fuselier J.A., Murphy W.A., Coy D.H. Antisense peptide nucleic acids conjugated to somatostatin analogs and targeted at the n-myc oncogene display enhanced cytotoxity to human neuroblastoma 1M.R.32 cells expressing somatostatin receptors. Peptides 2002 23 1557-1565. 

Somatostatin analogs are the mainstay of pharmacotherapy for the treatment of acromegaly when surgery and radiation are contraindicated or have failed. 

Somatostatin Analog (Growth Hormone-Inhibiting Hormone)... 

Use of the first-generation somatostatin analog octreotide is limited by its extremely short duration of action and requirement for subcutaneous administration at least three times a day. If a patient s GH level returns to baseline before the end of an 8-hour dosing interval, the frequency of octreotide administration can be increased to every 4 to 6 hours. Most patients require octreotide in doses of 100 to 200 meg three times daily.19,20 To improve patient tolerance to gastrointestinal (GI) adverse effects, start octreotide at 50 meg every 8 hours.20 Assess IGF-I serum concentrations every 2 weeks after initiating therapy to further titrate dose in increments of 50 meg per dose. 

Transient GI disturbances such as diarrhea, abdominal pain, flatulence, constipation, and nausea are commonly associated with somatostatin analogs.19,20 These adverse GI effects usually... 

Somavert ) daily daily fatigue, abnormal liver enzymes monthly for 6 months, then every 6 months MRI every 6 months. IGF-I (not GH) after first year, then yearly. levels not responsive to somatostatin analog-therapy... 

For patients receiving dopamine agonists, the maximal suppression of GH and IGF-I levels may take up to 3 months to achieve. Once stable control of biochemical markers is achieved with dopamine agonists or somatostatin analogs, monitor GH and IGF-I levels annually.6... 

Van Der Hoek, J.,De Herder, W. W., Feelders, R. A., Van Der Lely, A. J. and Lamberts, S. W. A single-dose comparison of the acute effects between the new somatostatin analog SOM230 and octreotide in acromegalic patients. J. Clin. Endocrinol. Metab. 89 638-645,2004. 

Fricker G, Nobmann S, Miller DS (2002) Permeability of porcine blood-brain barrier to somatostatin analogs. Brit J Pharmacol 135 1308-1314... 

Design of Novel Cyclic Hexapeptide Somatostatin Analogs from a Model of the Bioactive Conformation... 

FREIDINGER AND VEBER Cyclic Hexapeptide Somatostatin Analogs 171... 

Design of Cyclo Retro Isomeric Somatostatin Analogs. We have described our working computer-generated model for the bloactive... 

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