Genes function

What is the tissue specificity of the pathways and the gene function in relation to biological processes ... 

Fig. 4. A comparison of the approaches of reverse genetics and conventional genetics for the analysis of gene function.

The hypothesis that our biological world built on the DNA-RNA-protein central dogma was preceded by an RNA world in which RNA molecules carried both the genetic information and executed the gene functions (through ribozyme activity) is now widely accepted [130]. However, it is also well recognized that RNA due to its vulnerability to hydrolysis - especially as a result of catalysis by divalent metal ions - would not have been able to evolve in a harsh pre-biotic environment Also the formation of RNA under presumed pre-biotic conditions is extremely inefficient It is not so far-fetched to propose that a peptide nucleic acid-like molecule may have been able to function as a form of pre-biotic genetic material since it... 

BIRD C R, RAY J A, FLETCHER J D, BONIWELL J M, BIRD A S, TEULIERES C, BLAIN I, BRAMLEY P M and SCHUCH w (1991) Using antisense RNA to study gene function inhibition of carotenoid biosynthesis in transgenic tomatoes , BioTechnology, 9, 635-9. 

Heiss G, KW Hofmann, N Trachtmann, DM Walters, P Rouvihre, H-J Knackmuss (2002) npd gene functions of Rhodococcus (ppacus) erythropolis HL-PM-1 in the initial steps of 2,4,6-trinitrophenol degradation. Microbiology 148 799-806. 

Ihle JN 2000 The challenges of translating knockout phenotypes into gene function. Cell 102 131-134... 

Gene Function Animal model (Anticipated) phenotype of human disease... 

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