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Osteoporosis parathyroid hormone

A major regulator of bone metabolism and calcium homeostasis, parathyroid hormone (PTH) is stimulated through a decrease in plasma ionised calcium and increases plasma calcium by activating osteoclasts. PTH also increases renal tubular calcium re-absorption as well as intestinal calcium absorption. Synthetic PTH (1-34) has been successfully used for the treatment of osteoporosis, where it leads to substantial increases in bone density and a 60-70% reduction in vertebral fractures. [Pg.934]

Osteoporosis Encourage patients to ingest adequate amounts of calcium and vitamin D, encourage smokers to discontinue tobacco use, and consider initiation of medications for osteoporosis (e.g., bisphosphonates, calcitonin, and parathyroid hormone) if the patient is taking glucocorticoids for an extended period of time or if the patient has evidence of low bone mineral density.15,41... [Pg.877]

Compston, J. 2005. Recombinant parathyroid hormone in the management of osteoporosis. Calcified Tissue International 77(2), 65-71. [Pg.328]

Black DM, Greenspan SL, Ensrud KE, Palermo L, McGowan JA, Lang TF, et al. (2003) The effects of parathyroid hormone and alendronate alone or in combination in postmenopausal osteoporosis. N Engl J Med 349 1207-1215... [Pg.209]

The Ca -selective hormones calcitriol, parathyroid hormone, and calcitonin influence this interaction in the bone cells. Parathyroid hormone promotes Ca "" release by promoting the release of cytokines by osteoblasts. In turn, the cytokines stimulate the development of mature osteoclasts from precursor cells (bottom). Calcitonin inhibits this process. At the same time, it promotes the development of osteoblasts (top). Osteoporosis, which mainly occurs in women following the menopause, is based (at least in part) on a reduc-... [Pg.342]

Teriparatide is a recombinant form of parathyroid hormone, used in the treatment of advanced osteoporosis. [Pg.398]

Alternatives to steroid hormone therapy for osteoporosis include raloxifene, bisphosphonates, sodium fluoride, vitamin D and calcium supplementation, calcitonin, and parathyroid hormone. Tamoxifen has estrogenic effects on bone and delays bone loss in postmenopausal women. However as a result of estrogenic activity in the uterus, long-term tamoxifen administration has been associated with an increased risk of... [Pg.709]

Neer RM et al. Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis. N Engl J Med 2001 344 1434-1441. [Pg.761]

Cholecalciferol Regulate gene transcription via the vitamin D receptor Stimulate intestinal calcium absorption, bone resorption, renal calcium and phosphate reabsorption decrease parathyroid hormone (PTH) promote innate immunity inhibit adaptive immunity Osteoporosis, osteomalacia, renal failure, malabsorption Hypercalcemia, hypercalciuria the vitamin D preparations have much longer half-life than the metabolites and analogs... [Pg.974]

Finkelstein JS et al The effects of parathyroid hormone, alendronate, or both in men with osteoporosis. N Engl J Med 2003 349 1216. [PMID 14500805]... [Pg.978]

Teriparatide (Forteo) [Antiosteoporotic/Parathyroid Hormone] WARNING T Osteosarcoma risk in animals, therefore only use in pts for whom the potential benefits outweigh risks Uses Severe/refractory osteoporosis Action PTH (recombinant) Dose 20 meg SQ daily in thigh or abd Caution [C, /-] Contra w/ Paget Dz, prior radiation, bone metastases, T Ca2+ caution in urolithiasis Disp Inj SE Orthostatic X BP on administration, N/D, T... [Pg.298]

Other target organs for the action of 1,25-dihydroxyvitamin D include the kidneys, bone, muscle,vwand skin. The hormone promotes reabsorption of both Ca2+ and inorganic phosphate by kidney tubules. In bone it binds to a specific receptor where it promotes the mobilization of calcium ions. This effect may result in part from stimulation of calcium-activated ATPase of the outer membrane of bone cells. Dissolution of bone also requires the presence of parathyroid hormone (PTH), the 83-residue hormone secreted by the parathyroid gland. In women past the age of menopause and in elderly men the production of 1,25-dihydroxyvitamin D decreases.w This may be a cause of the serious bone loss (osteoporosis) frequently observed. Treatment with 1,25-dihydroxyvitamin D3 or a synthetic analog seems to be helpful to such individuals. /Xy See also Chapter 30, Section A,5. [Pg.1258]

Daily treatment with parathyroid hormone is associated with an increase in vertebral cross-sectional area in postmenopausal women with glucocorticoid-induced osteoporosis. Osteoporos Int 2003 14 77-81. [Pg.63]

McClung M. Parathyroid hormone for the treatment of osteoporosis. Obstet Gynaecol Surv 2004 59 826-32. [Pg.502]

Whitfield J, Morley P, Willick G. The parathyroid hormone, its fragments and analogues—potent bone-builders for treating osteoporosis. Expert Opin Investig Drugs 2000 9(6) 1293-315. [Pg.502]

Hodsman AB, Fraher LJ, Watson PH, Ostbye T, Stitt LW, Adachi JD, Taves DH, Drost D. A randomized controlled trial to compare the efficacy of cyclical parathyroid hormone versus cyclical parathyroid hormone and sequential calcitonin to improve bone mass in postmenopausal women with osteoporosis. J Clin Endocrinol Metab 1997 82(2) 620-8. [Pg.502]

Kurland ES, Cosman F, McMahon DJ, Rosen CJ, Lindsay R, Bilezikian JP. Parathyroid hormone as a therapy for idiopathic osteoporosis in men effects on bone mineral density and bone markers. J Clin Endocrinol Metab 2000 85(9) 3069-76. [Pg.502]

Neer RM, Arnaud CD, Zanchetta JR, Prince R, Gaich GA, Reginster JY, Hodsman AB, Eriksen EF, Ish-Shalom S, Genant HK, Wang O, Mitlak BH. Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis. N Engl J Med 2001 344(19) 1434-41. [Pg.502]

Morley P, Whitfield JF, Willick GE. Parathyroid hormone an anabolic treatment for osteoporosis. Curr Pharm Des 2001 7(8) 671-87. [Pg.502]

Body JJ, Gaich GA, Scheele WH, Kulkarni PM, Miller PD, Peretz A, Dore RK, Correa-Rotter R, Papaioannou A, Cumming DC, Hodsman AB. A randomized double-blind trial to compare the efficacy of teriparatide [recombinant human parathyroid hormone (1-34)] with alendronate in postmenopausal women with osteoporosis. J Clin Endocrinol Metab 2002 87(10) 4528-35. [Pg.502]

Rubin MR, Bilezikian JP. The potential of parathyroid hormone as a therapy for osteoporosis. Int J Fertil Womens Med 2002 47(3) 103-15. [Pg.502]

Lindsay R, Nieves J, Formica C, Henneman E, Woelfert L, Shen V, Dempster D, Cosman F. Randomised controlled study of effect of parathyroid hormone on vertebral-bone mass and fracture incidence among postmenopausal women on oestrogen with osteoporosis. Lancet 1997 350(9077) 550-5. [Pg.502]

Tashjian AH Jr, Chabner BA. Commentary on clinical safety of recombinant human parathyroid hormone 1-34 in the treatment of osteoporosis in men and postmenopausal women. J Bone Miner Res 2002 17(7) 1151-61. [Pg.502]

Osteoporosis Generalized bone demineralization often associated with effects of aging and hormonal changes in postmenopausal women Calcium supplements, vitamin D, calcitonin, bisphosphonates, intermittent parathyroid hormone, estrogen, or SERMs (raloxifene] (see Chapter 30]... [Pg.467]

See other pages where Osteoporosis parathyroid hormone is mentioned: [Pg.688]    [Pg.688]    [Pg.304]    [Pg.2041]    [Pg.863]    [Pg.1507]    [Pg.509]    [Pg.288]    [Pg.396]    [Pg.120]    [Pg.693]    [Pg.143]    [Pg.215]    [Pg.179]    [Pg.443]    [Pg.1750]    [Pg.32]    [Pg.500]    [Pg.502]    [Pg.139]    [Pg.159]    [Pg.471]   
See also in sourсe #XX -- [ Pg.86 , Pg.863 ]



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