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Parathyroid hormone recombinant human

Teriparatide, recombinant human parathyroid hormone) 1-34), is the first anabolic agent approved by the FDA for treatment of... [Pg.863]

Teriparatide is a recombinant product representing the first 34 amino acids in human parathyroid hormone. Teriparatide increases bone formation, the bone remodeling rate, and osteoblast number and activity. Both bone mass and architecture are improved. [Pg.42]

Y. Nabuchi, E. Fujiwara, H. Kuboniwa, Y. Asoh, H. Ushio, The Stability and Degradation Pathway of Recombinant Human Parathyroid Hormone Deamidation of Asparaginyl Residue and Peptide Bond Cleavage at Aspartyl and Asparaginyl Residues , Pharm. Res. 1997, 14, 1685-1690. [Pg.374]

Chemical Class Recombinant human ENDO-parathyroid hormone (rDNA origin) Clinical Pharmacology ... [Pg.1188]

Nabnchi, Y, E. Eujiwara, K. Ueno, H. Knboniwa,Y. Asoh, and H. Ushio, Oxidation of recombinant human parathyroid hormone effect of oxidized position on the biological activity. Pharm Res, 1995.12(12) 2049-52. [Pg.62]

E. coft-expressed recombinant human parathyroid hormone]... [Pg.314]

Body JJ, Gaich GA, Scheele WH, Kulkarni PM, Miller PD, Peretz A, Dore RK, Correa-Rotter R, Papaioannou A, Cumming DC, Hodsman AB. A randomized double-blind trial to compare the efficacy of teriparatide [recombinant human parathyroid hormone (1-34)] with alendronate in postmenopausal women with osteoporosis. J Clin Endocrinol Metab 2002 87(10) 4528-35. [Pg.502]

Tashjian AH Jr, Chabner BA. Commentary on clinical safety of recombinant human parathyroid hormone 1-34 in the treatment of osteoporosis in men and postmenopausal women. J Bone Miner Res 2002 17(7) 1151-61. [Pg.502]

Vahle JL, Sato M, Long GG, Young JK, Francis PC, Engelhardt JA, Westmore MS, Linda Y, Nold JB. Skeletal changes in rats given daily subcutaneous injections of recombinant human parathyroid hormone (1-34) for 2 years and relevance to human safety. Toxicol Pathol 2002 30(3) 312-21. [Pg.502]

The use of commercial kits eliminates the time required to produce and characterize Ab reagents. However, method validation must be conducted to show that the kit developed for diagnostic use is suitable for the intended PK study application. The kit selection and method validation processes are illustrated here for the bio-analytical application of a recombinant human parathyroid hormone (rhPTH) drug, ALX1-11 (Preos , NPS Pharmaceuticals). [Pg.169]

Recombinant human parathyroid hormone (1-34) Identical sequence to the 34N-terminal amino acids of the 84-amino acid human parathyroid hormone... [Pg.450]

Teriparatide is a recombinant human parathyroid hormone which promotes bone growth. It is available in the form of an injection and only prescribed by osteoporosis specialists. NICE have issued guidance on who is eligible to receive it. [Pg.272]

Teriparatide (a recombinant human parathyroid hormone) stimulates bone formation and is given daily by subcutaneous injection. There is evidence that teriparatide reduces vertebral and non-vertebral fractures. NICE recommends that it should be considered for the secondary prevention of osteoporotic fragility fractures in women aged 65 years and over who are intolerant of... [Pg.438]

Sukovaty, R.L., Lee,J.W., Fox,J., Toney, K., Papac, D.I., Thomas, A., Grover, T.A., and Wells, D.S. (2006) Quantification of recombinant human parathyroid hormone (rhPTH(l 84)) in human plasma by immunoassay commercial kit evaluation and validation to support pharmacokinetic studies. Journal ofPharmaceutical and Biomedical Analysis, 42, 261 271. [Pg.160]

Nineteen additional recombinant hormones have been approved thus far. These include a number of recombinant versions of human growth hormone (hGH), various gonadotropins, glucagon, parathyroid hormone and calcitonin (Table 4). Amongst these Somaverf is notable in that it is a recombinant PEGylated analog of hGH. It... [Pg.30]

Forteo (Forsteo in EU teriparatide recombinant shortened form of human parathyroid hormone, produced in E. coli). Eli Lilly treatment of osteoporosis in selected postmenopausal women 2002 (US), 2003 (EU)... [Pg.31]

USA teriparatide peptide Forteo Fosteo Recombinant 1-34 residues of human parathyroid hormone expressed in E. coli Hormone... [Pg.480]

Nabuchi Y, Fujiwara E, Kuboniwa H, et al. (1997). The stability and degradation pathway of recombinant human parathyroid hormone Deamidation of asparaginyl residue and peptide bond cleavage at aspartyl and asparaginyl residues. Pharm. Res. 14 1685-1690. [Pg.404]

An New Drug Application (NDA) for a full-length recombinant human parathyroid hormone (Preos) is currently under review by the U.S. FDA. [Pg.1422]

See other pages where Parathyroid hormone recombinant human is mentioned: [Pg.59]    [Pg.861]    [Pg.315]    [Pg.326]    [Pg.179]    [Pg.39]    [Pg.170]    [Pg.209]    [Pg.439]    [Pg.339]    [Pg.2731]    [Pg.4]    [Pg.80]    [Pg.290]    [Pg.373]    [Pg.375]    [Pg.271]    [Pg.311]    [Pg.291]   
See also in sourсe #XX -- [ Pg.73 ]



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