National Registry of Drug-Induced Ocular Side Effects

Depression accounted for 17% of 369 central nervous system reactions to timolol reported to a National Registry of Drug-induced Ocular Side Effects during 7 years of these, 20 cases were of acute suicidal depression. 

Data collected by the National Registry of Drug-Induced Ocular Side Effects suggest that, in the general population, a group of patients may have certain risk factors for side effects from topical ocular 10% phenylephrine. Of 15 patients with myocardial infercts, 11 died after topical application of 10% phenylephrine. The average age of these patients was 71 years, and nine individuals had a history of cardiovascular disease. 

Based on data submitted to the National Registry of Drug-Induced Ocular Side Effects and those acquired by other investigators, the following guidelines for the clinical use of 10% phenylephrine are suggested ... 

Fraunfelder FW. Ocular adverse drug reactions and the National Registry of Drug-Induced Ocmar Side Effects. Insight 2004 29 7-11. 

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