Cardiovascular effect

Dr. Kenneth Mukamal sfindings were published in January 2003. The news just gets better. A study whose Jindings were released in March 2004 suggested that moderate drinking not only had protective cardiovascular effects, but that it was also protective for people with hypertension. 

Relatively selective stimulation of Pi-adrenergic receptors can be achieved with dobutamine. This is a racemic drug of which both isomers activate the Pi-receptor, and in addition the (-) isomer activates ( -receptors whereas the (+) isomer activates p2-receptors the simultaneous activation of ai- and p2-receptors results in no major net effect on peripheral resistance, and thus the overall cardiovascular effects are mediated by Pi-stimulation leading to increases in cardiac contractility and output. Dobutamine is used for the short-term treatment of acute cardiac failure and for diagnostic purposes in stress echocardiography. 

Formerly known as PT-141 from Palatin Technologies is in phase 2 clinical trials. It is a melanocortin receptor agonist and is being trialled for male and female sexual dysfunction and is believed to have none of the cardiovascular effects possibly associated with other therapies. 

There is a decreased effectiveness of ritodrine when the drug is administered with a -adrenergic blocking agent such as propranolol and an increased risk of pulmonary edema when administered with the corticosteroids. Co-administration of ritodrine with the sym-pathomimetics potentiates the effect of ritodrine. Cardiovascular effects (eg, arrhythmias or hypotension) of ritodrine may increase when the drug is administered with diazoxide, general anesthetics, magnesium sulfate, or meperidine... 

Cardiovascular Effects. A number of eardiovaseular lesions, such as acute myoeardial degeneration and vascular degeneration, eongestion, and hemorrhage, have been observed in individuals exposed to... 

Cardiovascular Effects. Eesions in the heart and blood vessels have been reported in humans acutely intoxicated with methyl parathion (Wofatox) (Fazekas 1971) and are discussed in Section 3.2.2.2. However, many of these lesions may be secondary to the effects of methyl parathion on the conduction system of the heart, to other components ingested, or to therapeutic regimens that some of these patients received. 

Cardiovascular Effects. No studies were located regarding cardiovascular effects in humans after inhalation exposure to endosulfan. Routine gross and histopathologic examination of the heart and aorta of rats exposed (nose-only) to concentrations of endosulfan of up to 2 mg/m for 6 hours/day,... 

Cardiovascular Effects. Both tachycardia and bradycardia were noted among 18 agricultural workers in India who applied endosulfan without protective equipment (both dermal and inhalation exposures probably occurred) (Chugh et al. 1998). 

Stagnone GJ, Orgel MB, Stagnone JJ (1987) Cardiovascular effects of topical 50% trichloroacetic acid and Baker s phenol solution. J Dermatol Surg Oncol 13 999-1002... 

In this article we will describe the possible roles of cardiac mast cells and their mediators during anaphylactic reactions in man and will briefly review the cardiovascular effects of mast cell-derived mediators in vivo. 

Cysteinyl leukotrienes can induce an early, transient fall in arterial pressure associated with sympathoadrenergic activation, plus a late rise in small coronary arteriolar resistance [32]. Using specific antagonists of CysFTi and CysFT2 [63] it will be possible to assess the each receptor s contribution to the cardiovascular effects of these vasoactive mediators. 

Vigorito C, Russo P, Picotti GB, Chiariello M, Poto S, Marone G Cardiovascular effects of histamine infusion in man. J Cardiovasc Pharmacol 1983 5 531. Patterson LJ, Milne B Latex anaphylaxis causing heart block role of ranitidine. Can J Anaesth 1999 46 776. 

Oppenheimer SM, Gelb A, Girvin JP, Hachinski VC. Cardiovascular effects of human insular cortex stimulation. Neurology 1992 42(9) 1727-1732. 

Cardiovascular Effects. In one case study, a woman who had accidentally consumed about 20 mL of trichloroethylene was reported to have suffered a myocardial infarction within 2 hours of ingestion (Morreale 1976). In two other case studies, men who ingested 350 and 500 mL of trichloroethylene had ventricular arrhythmias that persisted for up to 3 days (Dhuner et al. 1957). The arrhythmias were described as ventricular tachycardia with extrasystoles from different ventricular foci. Cardiac arrhythmia was also reported in a women who drank an unknown amount of trichloroethylene (Perbellini et al. 1991). 

Cardiovascular Effects. Chronic cardiovascular disease has not been reported in workers occupationally exposed to low levels of trichloroethylene (El Ghawabi et al. 1973), although deaths following acute high-level inhalation exposures to trichloroethylene have been attributed to cardiac arrhythmias. Case studies have described cardiac arrhythmias that in some instances led to death after occupational exposure (Bell 1951 Kleinfeld and Tabershaw 1954 Smith 1966), poisoning (Dhuner et al. 1957 Gutch et al. 1965), or... 

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