Sarin ocular effects

A special issue from this Japanese experience are ocular effects of poisoning with sarin and their treatment. Some authors unsuccessfully treated strong miosis and consequential visual darkness with systemic atropine [15, 29], Others used 0.25% or 1.0% atropine sulphate eye drops, but these patients complained of atropine-induced photophobia and poor focusing [25], Our suggestion for optimal treatment of ocular manifestations of intoxication with organophosphorus cholinesterase inhibitors is topical use of pralidoxime chloride eye drops instead of atropine [42], Ocular pain should be treated with tropicamide 0.5% [28],... 

Dabisch PA, Miller DB, Burnett DC, Jakubowski EM, Muse WT, Forster JS, Davis FA, Jarvis JR, Scotto JA, Hulet SW, Reutter SA, Mioduszewski RJ, Thomson SA. Tolerance to the miotic effect of sarin vapor following multiple low-level exposures. J Ocular Pharmacol Ther 21(3) 182-195, 2005b. 

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