Gastrointestinal effects

CI-979 (29) is a balanced muscarinic agonist having equal affinities for cloned ml and m2 receptors (144). However, unlike prototypical muscarinic compounds such as (25), (29) increases central muscarinic tone, as indicated by behavioral and electroencephalogram (EEG) parameters, at doses lower than those requited to produce gastrointestinal effects (144). CI-979 is well tolerated in humans up to a dose of 1 mg. Dose-limiting side effects such as stomach pain and emesis were observed at a dose of 2 mg. 

Lowest observed effect level (PbB) (Mg/dl) Heme synthesis and hematological effects Neurological effects Renal system effects Gastrointestinal effects ... 

Dementia with Lewy bodies (DLB) is considered the second most common cause of dementia after AD. The disorder is characterized by progressive fluctuating cognitive impairment, visual hallucinations and motor features of Parkinsonism. Neocoitical cholinergic activity is more severely depleted in DLB than in AD, and DLB also affects the caudate nucleus, the thalamus and the brain stem. Tolerability of ChEI in DLB appears similar to AD, with some gastrointestinal effects and muscle cramps. 

ADMINISTERING PROCAINAMIDE Adverse reactions with procainamide therapy include nausea, loss of appetite, and vomiting. Small meals eaten frequently may be better tolerated than three full meals. Administering the drug with meals may decrease gastrointestinal effects. 

Although rare, side effects such as nausea and other mild gastrointestinal effects may occur. Individuals with allergiesto daisy-type ptantsare more susceptible to reactions... 

Saw palmetto (cabbage palm, fan palm, scrub palm) Serenoa repens %mptoms of benign prostatic hyperplasia Generally well-tolerated occasional gastrointestinal effects May interact with hormones such as oral contraceptive drugs and hormone replacement therapy. 

Major gastrointestinal effects include decreased gut motility and changes in secretion of gastric and intestinal fluids. Morphine and most p receptor agonists cause pupillary constriction. Some tolerance to this effect may develop, but addicts with high opioid levels will still have miosis. Respiratory depression is the usual cause of death from opioid overdose. 

Gastrointestinal Effects. Nausea, gagging, vomiting, and diarrhea were part of the clinical syndrome exhibited by persons who consumed high doses Gethal in some cases) of endosulfan either intentionally or accidentally (Blanco-Coronado et al. 1992 Pradhan et al. 1997 Terziev et al. 1974). However, it is unclear whether these effects were the result of gastrointestinal irritation or were mediated... 

Gastrointestinal Effects. Case reports indicate that acute inhalation exposure to trichloroethylene results in nausea and vomiting (Buxton and Hayward 1967 Clearfield 1970 David et al. 1989 DeFalque 1961 Gutch et al. 1965 Milby 1968). Anorexia, nausea, vomiting, and intolerance to fatty foods have also been reported after chronic occupational exposure to trichloroethylene (El Ghawabi et al. 1973 Schattner and Malnick 1990 Smith 1966). Trichloroethylene-induced efiects on the autonomic nervous system may contribute to these effects (Grandjean et al. 1955). Some of the people exposed to trichloroethylene and other chlorinated... 

Based on the limited human and animal data, it is not possible to predict whether or not triehloroethylene exposure at levels found in the environment and at hazardous waste sites can result in gastrointestinal effects. 

Misoprostol is a synthetic prostaglandin E2 analog that exogenously replaces prostaglandin stores. The minimum effective dose shown to inhibit acid secretion and promote mucosal defense is 400 meg/day. Misoprostol use is limited by a high frequency of bothersome gastrointestinal effects such as abdominal pain, flatulence, and diarrhea. In placebo-controlled studies diarrhea occurred with twice the frequency in the... 

Use of intravenous colchicine to circumvent adverse gastrointestinal effects is discouraged due to the increased risk of serious and potentially fatal systemic effects with this route. The intravenous form should not be used in patients with moderate or more severe renal impairment (creatinine clearance less than or equal to 50 mL/minute), and total doses should not exceed 4 mg in a 7-day period. The potential extravasation of intravenous colchicine is also a concern. 

Ethionamide Adults 15-20 mg/kg per day, usually 500-750 mg/day in a single daily dose or two divided doses Children 15-20 mg/kg per day Gastrointestinal effects, hepatotoxicity, neurotoxicity, endocrine effects Baseline FFTs Monthly FFTs if underlying liver disease is present TSH at baseline and monthly intervals... 

No data were located regarding gastrointestinal effects, endocrine effects, dermal effects, or ocular effects in humans or animals following acute-, intermediate-, or chronic-duration inhalation exposure to americium. 

No data were located regarding systemic effects in humans following acute-, intermediate-, or chronic-duration exposure to americium by routes other than inhalation, oral, dermal, or external exposure. No data were located regarding respiratory effects, cardiovascular effects, gastrointestinal effects, renal effects, dermal effects, ocular effects, or metabolic effects animals following exposure to americium by routes other than inhalation, oral, dermal, or external exposure. 

Gastrointestinal Effects. No studies were located regarding gastrointestinal effects in humans after oral exposure to diisopropyl methylphosphonate. 

In a study of calves dosed with diisopropyl methylphosphonate at 62.5, 125, 250, 500, or 1,000 mg/kg via gelatin capsules placed with a balling gun, calves that died at the highest dose level displayed acute gastroenteritis and ecchymotic hemorrhaging upon necropsy (Palmer et al. 1979). No gastrointestinal effects were observed at sublethal dose levels. 

Individual sensitivity to coffee drinking may or may not be related to its caffeine content. Other compounds found in coffee are probably responsible, as the same individuals can often drink tea without adverse gastrointestinal effect. 

In some studies, over 60% of participants reported adverse gastrointestinal effects of coffee, such as acid indigestion, heartburn, abdominal pain, and symptoms due to gas or constipation. 

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