Neurological impairments

Lead is known to cause reproductive and developmental toxicity. Decreased sperm counts and abnormal sperm development have been reported in male workers heavily exposed to lead. Increased incidences of spontaneous abortion have been reported in female lead workers as well as in the wives of male lead workers (13). Lead crosses the placenta and has been found to cause irreversible neurologic impairment to the fetus at maternal blood levels as... 

Lead Incineration, smelting and casting, transportation. Copper and lead smelting, MSWs Neurological impairments kidney, hver, and heart damage. 

Calcium-containing antacids—rebound hyperacidity, metabolic alkalosis, hypercalcemia, vomiting, confusion, headache, renal calculi, and neurologic impairment... 

Interest in import of proteins into peroxisomes has been stimulated by studies on Zellweger syndrome. This condition is apparent at birth and is characterized by profound neurologic impairment, victims often dying within a year. The number of peroxisomes can vary from being almost normal to being virtually absent in some patients. Biochemical findings include an accumulation of very long chain fatty acids, abnormalities of... 

Seizure observed at stroke onset with postictal residual neurological impairments... 

Gastroesophageal reflux occurs in approximately 18% of infants. As in adults, transient lower esophageal sphincter relaxations appear to be the most common cause of GERD.26 This is due to developmental immaturity of the lower esophageal sphincter.27 Other causes include impaired luminal clearance of gastric acid, neurologic impairment, and type of infant formula. 

Cardiovascular Left ventricular hypertrophy, ECG changes, congestive heart failure Neurologic Impaired mental cognition Genitourinary Sexual dysfunction... 

Septic patients may have an elevated, low, or normal temperature. The absence of fever is common in neonates and elderly patients. Hypothermia is associated with a poor prognosis. Hyperventilation may occur before fever and chills and may lead to respiratory alkalosis. Disorientation and confusion may develop early in septic patients, particularly in the elderly and patients with preexisting neurologic impairment. Disorientation and confusion may be related to the infection or due to sepsis signs and symptoms (e.g., hypoxia). 

NS (occup) Neurological Impaired postural balance 36 (mean) Chiaetal. 1996... 

NS (children, environmental exposure) Neurological Impaired motor and cognitive function 40-50,20 years before testing current mean, 2.9 Stokes et al. 1998... 

Health effects that have been associated with lead exposures during infancy or childhood include, anemia (Schwartz et al. 1990) (and related disorders of heme synthesis), neurological impairment (e.g., encephalopathy), renal alterations, and colic (Chisolm 1962, 1965 Chisolm and Harrison 1956), and impaired metabolism of vitamin D (Mahaffey et al. 1982 Rosen and Chesney 1983). Death from encephalopathy may occur with PbB levels 125 pg/dL. In addition to the above effects, the following health effects have been associated with lead exposures either in utero, during infancy or during... 

Signs and Symptoms Symptoms are acute and include fever, headache, encephalitis, vesicular skin lesions at site of the exposure, and variable neurological patterns. Involvement of the respiratory center and death usually occurs in 1-21 days after onset of symptoms. Survivors usually have considerable residual disability. May produce severe permanent neurologic impairment requiring lifelong institutionalization. 

Research has resulted in major advances in animal modeling of anti-glycolipid antibody-associated neuropathies in vitro and in vivo, which make a strong case that the antibodies cause much of the neurological impairment in these patients [21]. Furthermore, molecular... 

A number of other conditions must also be excluded, such as medication-induced parkinsonism (e.g., induced by antipsychotics, phenothiazine antiemetics, or metoclopramide). Other diagnostic criteria include lack of other neurologic impairment. 

EN is indicated for the patient who cannot or will not eat enough to meet nutritional requirements and who has a functioning GI tract. Additionally, a method of enteral access must be possible. Potential indications include neoplastic disease, organ failure, hypermetabolic states, GI disease, and neurologic impairment. 

Lithium toxicity can occur with serum levels greater than 1.5 mEq/L, but the elderly may have toxic symptoms at therapeutic levels. Severe toxic symptoms may occur with serum concentrations above 2 mEq/L, including vomiting, diarrhea, incontinence, incoordination, impaired cognition, arrhythmias, and seizures. Permanent neurologic impairment and kidney damage may occur as a result of toxicity. 

Engelhart, C., Eisenstein, N., Johnson, V., Wolf, J., Williamson, J., Steitz, D., Girard, V., Paramatmuni, K., Ouzounian, N., Losonczy, M. (1999). Factor structure of the Neurobehavioral Cognitive Status Exam (COGNISTAT) in healthy and psychiatrically and neurologically impaired, elderly adults. Clinical Neuropsychology, 13, 109-111. 

The scoring used for children (age 4 or 5-11 years) differs from that used for adults (age 15-adult). This test measures perceptual maturity, possible neurological impairment, and emotional adjustment in children. It measures maturation, intelligence, psychological disturbance, and cortical impairment in adults. The test requires 10 minutes to complete. Scores may fluctuate from test to test and thus must be interpreted carefully. 

Rats exposed to 16-1,694 mg/kg/day and mice exposed to 25-2,642 mg/kg/day phenol in drinking water exhibited no abnormal histology of the brain after 13 weeks of exposure (NCI 1980). Histopathological changes in the brain were not evident after 103 weeks of exposure to 322 or 645 mg/kg/day in male rats, 360 or 721 mg/kg/day in female rats, 590 or 1,180 mg/kg/day in male mice, and 602 or 1,204 mg/kg/day in female mice (NCI 1980). However, this study did not include tests for neurological impairment or histopathological examinations of tissues in the nervous system other than the brain. 

Toxicology. Dimethyl hydrogen phosphite (DMHP) is an irritant of the eyes, mucous membranes, and skin it causes neurological impairment and reversible cataracts in animals it is carcinogenic in rats and causes testicular atrophy in mice. 

Humans exposed to 3 76 ppm experienced eye and nasal irritation within 15 minutes after I hour at 3 76 ppm, effects were headache, nausea, decreased dexterity and coordination, and other signs of transient neurological impairment. Subjective complaints, including... 

Frequently monitor patients for signs and symptoms of neurological impairment. If neurological compromise is noted, urgent treatment is necessary. 

Irreversible inhibition of the enzyme leads to accumulation of acetylcholine at these synapses and conseguent neurologic impairment. 

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