Dimethyl hydrogen phosphite

Kleiman, Y. L., Morkovin, N. V., Ionin, B. I. Effect of Solvents and Temperature on Spin-Spin Interaction Constant 1 Jjjp in Dimethyl Hydrogen Phosphite. J. Gen. Chem. R. 37, 2661(1967). 

Toxicology. Dimethyl hydrogen phosphite (DMHP) is an irritant of the eyes, mucous membranes, and skin it causes neurological impairment and reversible cataracts in animals it is carcinogenic in rats and causes testicular atrophy in mice. 

The acute oral LDso values for dimethyl hydrogen phosphite were 3300 and 3 000 mg/ kg body weight (bw) for male and female Fischer 344/N rats, respectively, and 2800mg/ kg bw for male B6C3F1 mice. ... 

Dimethyl hydrogen phosphite was not mutagenic to several strains of Salmonella lyphimurium, but it did cause sister chromatid exchanges and chromosomal aberrations in the Chinese hamster CHO line. ... 

An ACGIH threshold limit value (TLV) has not been established for dimethyl hydrogen phosphite. 

Nomeir AA, Uraih LC Pathological and biochemical effects of dimethyl hydrogen phosphite in Fischer 344 rats. Fundam Appl Toxicol 10 114-124, 1988... 

Nomeir AA, Matthews HB Metabolism and disposition of dimethyl hydrogen phosphite in rats and mice. J Toxicol Environ Health 51(50) 489-501, 1997... 

A. CHLORO(DIMETHYL HYDROGEN PHOSPHITE-P) (DIMETHYL PHOSPHITO-/ ) (TRIPHENYLPHOSPHINE) PLATINUM(II)... 

Bis(dimethyl hydrogen phosphite-/ )bis(dimethyl phosphito-P)platinum(lI) (0.420 g, 0.66 mmole) and c/s-[dichlorobis(triphenylphosphine)platinum(ll)] (0.524 g, 0.66 mmole) are refluxed in toluene (25 mL) for 30 hours. The colorless reaction mixture is filtered while hot using vacuum to remove any unreacted c/s-[dichlorobis(triphenylphosphine)platinum(Il)]. The filtrate is transferred to a 100-mL, round-bottomed flask and evaporated to dryness on a rotary evaporator, using gentle heating if necessary. The cream-colored residue is dissolved in a mixture of dichloromethane (15 mL) and methanol (15 mL) and the solution is allowed to concentrate slowly under water aspirator vacuum on a rotary... 

This procedure is similar to that used for the synthesis of bis(dimethyl phosphito-P)[ethylenebis(diphenylphosphine)]platinum(Il).8 To a solution of bis(dimethyl hydrogen phosphite-i>)bis(dimethyl phosphito- )platinum(II) (0.976 g, 1.5 mmole) in benzene (50 mL) is added o-phenylenebis(dimethylarsine) 9 (0.441 g, 1.5 mmole). The solution is heated at reflux with stirring for 1 hour and then allowed to cool to room temperature. The colorless compound precipitates and is collected by suction filtration on a medium-porosity fritted glass. The complex is washed with benzene (two 5-mL portions) and then... 

Dimethyl hydrogen phosphite 1,4 Dimethylphenanthrene Dimethyl sulfate... 

Dimethyl hydrogen phosphite is used as a flame retardant on nylon 6 fibres, as a chemical intermediate in the production of pesticides and in lubricant additives and adhesives. No data on occupational exposure levels were available. A potential source of exposure to this chemical is from its occurrence as a degradation product of the chemical intermediate trimethyl phosphite and of pesticides such as trichlorphon and malathion (lARC, 1990). 

Dimethyl hydrogen phosphite was tested for eareinogenicity by oral administration in one strain of miee and in one strain of rats. In rats, it eaused an increase in the incidence of alveolar/bronchiolar carcinomas in animals of each sex and of squamous-cell carcinomas of the lung and of papillomas and carcinomas of the forestomach in males (lARC, 1990). 

In single studies, dimethyl hydrogen phosphite induced sister chromatid exchanges... 

Table 1. Genetic and related effects of dimethyl hydrogen phosphite... 

Dimethyl hydrogen phosphite has been reported to induce unscheduled DNA synthesis in hepatocytes of rats that had been treated with Aroclor or 3-methylcholanthrene. 

No epidemiological data relevant to the carcinogenicity of dimethyl hydrogen phosphite were available. 

Dimethyl hydrogen phosphite is not classifiable as to its carcinogenicity to humans (Group 3). 

The Step 1 product (1 mol) was mixed with di-t-butyl peroxide (O.lmol) and then added to a second flask containing dimethyl hydrogen phosphite (1.1 mol) and heated for 5.5 hours at between 130°C and 135°C. At the conclusion of the reaction excess dimethyl hydrogen phosphite was removed under vacuum, and the product was isolated. 

DIMETHYLHYDRAZINO)ACRIDINE MONOHYDROCHLORIDE see DSG330 2-(2,2-DIMETHYLHYDRAZINO)-4-(5-NTTRO-2-FURYL)THIAZOLE see DSG400 DIMETHYL HYDROGEN PHOSPHITE see DSG600 DIMETHYLHYDROGENPHOSPHITE see DSG600 DIMETHYL-2,5 (HYDROXY 4 BENZOYL) 3 FURANNE see DSClOO... 

Octahedral and tetrahedral solvates (A1S )(C104)3 [n = 4,6 S = trimethyl phosphate (TMPA), hexamethylphosphorotriamide (HMPT), triethyl phosphate (TEPA), dimethyl methylphosphonate (DMMP), diethyl ethylphosphonate (DEEP), and dimethyl hydrogen phosphite (DMHP)] are shown by Al NMR to have tetrahedral and octahedral structures which are retained in nitromethane solution. 

Arbuzov, B.A., Polozov, A.M., and Polezhaeva, N.A., Catalytic and thermal decomposition of 2-diazo-l,3-diphenyl-l,3-propanedione in dimethyl hydrogen phosphite and O,O-diethyl hydi ogen phospho-rothioite, Zh. Obshch. Khim., 54, 1517, 1984 J. Gen. Chem. USSR (Engl. Transl.), 54, 1351. 1984. Arbuzov, B.A., Polozov, A.M., and Polezhaeva, N.A., P-H addition of carbenoids and carbenes as a method for the synthesis of 2-phospho-substituted 1,3-dicarbonyl compounds, Dokl. Akad. Nauk SSSR, Ser. Khim., 287, 849, 1986 Dokl. Chem. (Engl. Transl.), 287, 69, 1986. 

DMHP dimethyl (hydrogen] phosphite DEHP diethyl [hydrogen] phosphite Sulfur monochloride Sulfur dichloride Thionyl chloride Ethyldiethanolamine Methyldiethanolamine Triethanolamine... 

Optically active phosphorus(iii) acid esters PhR P (OR ) have recently been prepared for the first time by the reaction of a chiral phosphorus chloride and an alcohol or thiol in the presence of an optically active amine, in this case (-)-NN-dimethyl-(l-phenylethyl)amine. (See also Refs. 449 and 450). A kinetic investigation shows that phosphorous acid and chloral react to give 2,2,2-trichloro-l-hydroxyethyl phosphonate at a much lower rate than the corresponding reaction with dimethyl hydrogen phosphite. Phosphorus trichloride and dialkyl phosphites (R0)2P(0)H have been shown to react at low temperature in the presence of pyridine, producing tris(dialkoxyphosphoryl)phosphines [(RO)2P(0)]3P. ... 

---