Neuroimmunology

Berman NE, Marcario JK, Yong C et al (1999) Microglial activation and neurological symptoms in the SIV model of NeuroAIDS association of MHC-II and MMP-9 expression with behavioral deficits and evoked potential changes. Neurobiol Dis 6 486 98 Biber K, Zuurman MW, Dijkstra IM et al (2002) Chemokines in the brain neuroimmunology and beyond. Curr Opin Pharmacol 2 63-68... 

Evidence for a neuroimmunological involvement in Alzheimer s disease is accumulating. Activation of the complement cascade by beta amyloid (Rogers et al., 1992), the recruitment, proliferation and activation of microglia in intimate juxtaposition to the senile plaques (Davis et al., 1992), and the increased synthesis of microglia-derived pro-inflammatory cytokine interleukin-1 (Griffin et al., 1989) is indicative of a chronic inflam-... 

Biber K, Zuurman MW, Dijkstra IM, et al. Chemokines in the brain neuroimmunology and beyond. Curr Opin Pharmacol 2002 2 63-68. 

Cabral GA and Pettit DAD (1998). Drugs and immunity Cannabinoids and their role in decreased resistance to infectious disease. Journal of Neuroimmunology, 83, 116-123. 

Costa, P., Auger, C.B., Traver, D.J. and Costa, L.G. (1995) Identification of m3, m4 and m5 subtypes of muscarinic receptor mRNA in human blood mononuclear cells. Journal of Neuroimmunology 60, 45-51. 

Dardenne, M. and Savino, W. 1996. Interdependence of the endocrine and immune systems. Advances in Neuroimmunology 6(4), 297-307. 

Laboratory of Reference for CSF and Neuroimmunology Homolka Hospifal Prague, Czech Republic toeparfmenf of Immunology Public Healfh Institute,... 

Neuroimmunological reactions. The humoral immune response in CNS is different from the immune response usually observed in blood. As a main difference, we find no switch from the IgG-class response to a more speciflc IgG-class response in the course of inflammatory disease. The pattern of intrathecal IgG/IgA/IgM synthesis remains rather constant and depends on the causes, pathophysiology, and localization of the disease process (R4). 

As a second difference in neuroimmunological processes, we find a slow, long-lasting decay of intrathecal antibody synthesis, sometimes detectable 10-15 years after sufficient treatment (neurosyphilis, neuroborelliosis, or HSV encephalitis). 

R4. Reiber, H., Diagnostic implication of neuroimmunological reaction patterns in cerebrospinal fluid. Lab. Med. 19, 444 62 (1995). 

Pavel Adam (1), Laboratory of Reference for CSF and Neuroimmunology, Homolka Hospital, 150 30 Prague 5, Czech Republic... 

Neuroimmunology Branch, National Institutes of Health, Bethesda, MD 20205... 

Rogers NL, Szuba MP, Staab JP, Evans DL, Dinges DF. Neuroimmunologic aspects of sleep and sleep loss. Semin in Clin Neuropsychiatry 2001 6 295-307. 

Majde JA, Krueger JM. Neuroimmunology of sleep. In D haenen H, DeBoer JA, Westemberg H, Willner P, eds. Textbook of Biological Psychiatry. London Wiley, 2002. 

Lawrence DM, Major EO (2002) HIV-1 and the brain connections between HIV-l-associated dementia, neuropathology and neuroimmunology. Microbes Infect 4 301-8 Lee HC (2001) Physiological functions of cyclic ADP-ribose and NAADP as calcium messengers. Annu Rev Pharmacol Toxicol 41 317—45... 

Roberts WK, Darnell RB. Neuroimmunology of the paraneoplastic neurological degenerations. Curr Opin Immunol 2004 16(5) 616-622. 

Willison HJ, Ang W, Gilhus NE, Graus F, Liblau R, Vedeler C, et al. EFNS task force report A questionnaire-based survey on the service provision and quality assurance for determination of diagnostic autoantibody tests in European neuroimmunology centres. European Federation of Neurological Societies. Eur J Neurol 2000 7(6) 625-628. 

Ashwood, P., Schauer, J., et al. (2009) Preliminary evidence of the in vitro effects of BDE4-7 on innate immune responses in children with autism spectrum disorders. Journal of Neuroimmunology, 208 (1-2) 130-135. 

The view of neuroimmunology has evolved from the dogma that regarded the CNS as an immune privileged site to a view of significant CNS-immune system interactions. Cytokines and grow th factors are important to the brain s immune... 

Chemokine s and their Receptors in Neurodegenerative and Neuroimmunologic Diseases... 

Lehmann HC, Hartung HP, Hetzel GR, Stuve O, Kieseier BC (2006) Plasma exchange in neuroimmunological disorders Part 1 Rado-nale and treatment of inflammatory cendal nervous system disorders. Arch Neurol 63 930-935. 

Yoshino H (1997) Distribution of gangliosides in die nervous tissues recognized by axonal form of Guillain-Bane syndrome (in Japanese). Neuroimmunology 5 174—175. 

MS is a chronic neurologic disease associated w ith demyelin-ation and death of neuronal axons. Multiple plaques or scares form w ithin the CNS resulting in a w ide range of neurological deficits. Because of the role of demyelination in the disease, it is frequently classified w ith autoimmune disorders. Information on the neuroimmunologic aspects of the various types of MS are covered in a previous chapter. 

Wu E, Dickson DW, Jacobson S, Raine CS (1993) Neuroaxonal dysti ophy in HTLV-1-associated myelopatlry/ti opical spastic pai apai esis Neuropatlrologic and neuroimmunologic coirelations. Acta Neui opatlrol (Berl) 86 224—235. 

Raison CL, Miller AH (2001) The neuroimmunology of sdess and depression. Semin Clin Neuropsychiady 6 277—294. 

Luccinetti s group (Lucchinetti et al., 1996 Lucchinetti et al. 2000) changed the w ay MS disease classifications w ere view ed w hen their pathologic studies confirmed that MS plaques differ. Neuroimmunologic evidence now suggests... 

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