Pathologic studies

Delage C, Irey HC Anaphylactic deaths a clinico-pathologic study of 43 cases. J Forens Sci 1972 17 ... 

Brockow K. Vieluf D. Puschel K. Grosch J. Ring J Increased postmortem serum mast cell tryptase in a fatal anaphylactoid reaction to nonionic radiocontrast medium. J Allergy Clin Immunol 1999 104 237-238. Delage C, Irey HC Anaphylactic deaths a clinico-pathologic study of 43 cases. J Forensic Sci 1972 17 525. 

Endo S, Nishijima M, Nomura H, Takaku A, Okada E. A pathological study of intracranial posterior circulation dissecting aneurysms with subarachnoid hemorrhage report of three autopsied cases and review of the literature. Neurosurgery 1993 33 732-738. 

Davis LE, Komfeld M, Mooney HS, Fiedler KJ, Haaland KY, Orrison WW, Cemichiari E, Clarkson TW. 1994. Methyhnercury poisoning long-term clinical, radiological, toxicological, and pathological studies of an affected family. Ann Neurol 35 680-688. 

Schuffler MD, Lowe MC, Bill AH Studies of idiopathic intestinal pseudoobstruction. I. Hereditary hollow visceral myopathy Clinical and pathological studies. Gastroenterology 1977 73 327-338. 

A comprehensive, up-to-date review A Biochemical, Genetic and Physio-pathological Study of Haptoglobin has recently been presented by Jayle and Moretti (J12). Since the present article is concerned mainly with problems of current interest in clinical work and research, the older literature will be dealt with only in brief outline. 

According to chnico-pathological studies, the diagnosis of probable AD can be made with an accuracy of about 85% while the diagnosis of definite AD stiU relies on post mortem neu-ropathological proof, apart from the rare case where a brain biopsy can be performed. A more sensitive and accurate diagnostic method, which should also be non-invasive, would be highly desirable [2]. 

Necropsies for pathological study were performed promptly on moribund mice which were killed within 2 hours of injection of toxin-LR. Mouse livers were dark red, markedly enlarged, and engorged with blood. The observed 50 percent increase in fresh weight of the liver is attributed to the accumulation of about one-half of the total circulating blood in and around hepatic blood channels. The cerebral cortex was slightly swollen and pale, and a thin film of pink ascitic fluid was sometimes seen. No other abnormalities were observed. 

Harding HE, McLaughlin AIG, Doig AT Clinical, radiographic, and pathological studies of the lungs of electric arc and oxy-acetylene welders. Lancet 2 394—398, 1958... 

Tl. Talerman, A., Clinico-pathological study of multiple myeloma in Jamaica. Brit. J. Cancer 23, 285-293 (1969). 

Pathology Study of the structural and functional changes in the body caused by disease. 

Singh S, Singh D, Wig N, et al. 1996. Aluminum phosphide ingestion - a clinico-pathologic study. Clin Toxicol 34 703-706. 

Hirano, A., Malamud, N., Elizan, T. S. and Kurland, L. T. (1966) Amyotrophic lateral sclerosis and Parkinsonism-dementia complex on Guam. Further pathologic studies. Arch Neurol 15, 35-51. 

Peer review of pathology studies resulted in different conclusions, with only the favorable one submitted to the FDA. 

Ihara, Y., Namba, R., Kuroda, S., Sato, T., and Shirabe, T., Mitochondrial encephalomyopa-thy (MELAS) Pathological study and successful therapy with coenzyme Qio and idebenone. J. Neurol. Sci. 90, 263-271 (1989). 

Lai MK, Tsang SW, Francis PT, et al. [3H]GR113808 binding to serotonin 5-HT4 receptors in the postmortem neocortex of Alzheimer disease a clinico-pathological study. J Neural Transm 2003 110 779-788. 

Amarenco P, Hauw JJ (1990) Cerebellar infarction in the territory of the anterior and inferior cerebellar artery. A clinico-pathological study of 20 cases. Brain 113 139-155 Baquis GD, Pessin MS, Scott RM (1985) Limb shaking - a carotid TIA. Stroke 16 444-448 Barth A, Bogousslavsky J, Regli F (1994) Infarcts in the territory of the lateral branch of the posterior inferior cerebellar artery. J Neurol Neurosurg Psychiatry 57 1073-1076 Baumgartner RW, Sidler C, Mosso M et al (2003) Ischemic lacunar stroke in patients with and without potential mechanism other than small-artery disease. Stroke 34 653-659... 

J Neurol Neurosurg Psychiatry 40 1182-1189 Fisher CM (1978) Ataxic hemiparesis. A pathologic study. Arch Neurol 35 126-128... 

In the past, two different basic mechanisms have been proposed to account for ischemic events in ICA occlusive disease (1) intracranial embolism and (2) a low-perfusion state also referred to as hemodynamic insufficiency. In the post-mortem arteriographic and pathologic study by Rodda and Path (1986), massive infarcts involving two major cerebral artery territories were associated with distal ICA occlusion, middle cerebral artery (MCA) territory infarcts were seen when the ICA was occluded or stenosed, and borderzone infarcts were characterized by ICA disease and limited circle of Willis anastomosis. 

Hormigo A, Dalmau J, Rosenblum MK, River ME, Posner JB. Immunological and pathological study of anti-Ri-associated encephalopathy. Ann Neurol 1994 36(6) 896-902. 

Oh SJ, Gurtekin Y, Dropcho EJ, King P, Claussen GC. Anti-Hu antibody neuropathy A clinical, electrophysiological, and pathological study. Clin Neurophysiol 2005 116(1) 28-34. 

Despite the infinitely greater sensitivity, usefulness, and relevance of autopsy examinations and microscopic pathology studies, no consistent finding of brain atrophy or any other pathology has been made despite hundreds of these studies performed on thousands of patients diagnosed... 

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