Neurochemical

Halliwell, B. (1992). Reactive oxygen species and the central nervous system. /. Neurochem. 59, 1609-1623. 

Starke K (2001) Presynaptic autoreceptors in the third decade focus on a2-adrenoceptors. J Neurochem 78 685-693... 

Mohler H (2007) Molecular regulation of cognitive functions and developmental plasticity impact of GABAa receptors. Neurochem 102 1-12... 

Bottner M, Krieglstein K, Unsicker K (2000) The transforming growth factor-(3s structure, signaling, and roles in nervous system development and functions. J Neurochem 75 2227-2240... 

Repeated intermittent exposure to stimulants can produce sensitization, where subsequent drag exposures produce increased behavioral and neurochemical responses. The ability of the drag and ultimately of related stimuli to elicit behavior may be increased with repeated administration or intake of the drag. Dopaminergic sensitization within the amygdala has also been found after repeated exposure to amphetamine and this... 

Berry MD (2004) Mammalian central nervous system trace amines. Pharmacologic amphetamines, physiologic neuromodulators. J Neurochem 90 257—271... 

Nowak, T.S., Bond, U., Schlesinger, M.J. (1990). Heat shock levels in brain and other tissues after hyperthermia and transient ischemia. J. Neurochem. 54,451-458. 

Allgaier C Ethanol sensitivity of NMDA receptors. Neurochem Int41 377—382,2002 American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders, 3rd Edition, Revised. Washington, DC, American Psychiarric Association, 1987... 

Miller LG, Greenblatt DJ, Barnhill JG, et ah Benzodiazepine receptor binding of tri-azolobenzodiazepines in vivo increased receptor number with low-dose alprazolam. J Neurochem 49 1595-1601, 1987... 

Pritchett DB, Seeburg PH Gamma-aminobutyric acidA receptor alpha3-subunit creates novel type II benzodiazepine receptor pharmacology. J Neurochem 34 1802-1804, 1990... 

The various stimulants have no obvious chemical relationships and do not share primary neurochemical effects, despite their similar behavioral effects. Cocaines chemical strucmre does not resemble that of caffeine, nicotine, or amphetamine. Cocaine binds to the dopamine reuptake transporter in the central nervous system, effectively inhibiting dopamine reuptake. It has similar effects on the transporters that mediate norepinephrine and serotonin reuptake. As discussed later in this chapter in the section on neurochemical actions mediating stimulant reward, dopamine is very important in the reward system of the brain the increase of dopamine associated with use of cocaine probably accounts for the high dependence potential of the drug. 

Swartz CM, Breen K, Leone F Serum prolactin levels during extended cocaine abstinence. AmJ Psychiatry 147 777—779, 1990 Sziraki I, Sershen H, Hashim A, et al Receptors in the ventral tegmental area mediating nicotine-induced dopamine release in the nucleus accumbens. Neurochem Res 27 253-261, 2002... 

Tryptamine itself is found in all major centers of the brain. Its physiologic role in central nervous system (CNS) function, however, remains unclear. 5-Hydroxytryptamine (5-HT, serotonin) is an important neurotransmitter in the CNS. The structural similarity of the tryptamine-related hallucinogens with 5-HT presumably forms the neurochemical basis for their action within the CNS. 

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