Neurochemical Aspects of Amyotropic Lateral Sclerosis

Free fatty acid composition Altered Farooqui and Horrocks (2007) 

Other neurological diseases. It is proposed that anti-SGPG antibodies may be responsible for the activation of endothelial cells in ALS and the increased expression of E-selectin may be related to immunological disturbances in some ALS patients (Ikeda et ah, 2000). 

ALS occurs in sporadic and familial forms. The pathogenesis of neuronal degeneration in both sporadic and familial ALS may involve mutations in copper/zinc superoxide dismutase, mitochondrial dysfunction (alterations in respiratory complexes I and III), protein aggregation, and neuroinflammation (Aimer et al., 2001 Liu et al., 2002). Cytosolic Cu/Zn superoxide dismutase (SODl) is a ubiquitous small cytosolic metalloenzyme that catalyzes the conversion of superoxide anion to hydrogen peroxide. The mutant copper/zinc superoxide dismutase exhibits a toxic gain of function that adversely affects the function of neurons in the spinal cord, brain stem, and motor cortex. 

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