Neurochemical Aspects of Neurodegenerative Diseases

Oligomerization of unfolded proteins, formation of ditfiused deposits 

misfolded Ap peptide 1-42 accumulates in the neuronal endoplasmic reticulum extracellularly as plaques. In contrast, in PD and dementia with Lewy bodies (DLB) abnormal accumulation of a-synuclein occurs in neuronal cell bodies, axons, and synapses. Furthermore, in DLB, Ap 1-42 has been reported to promote a-synuclein accumulation and neurodegeneration (Hashimoto et ah, 2003). 

Neurodegenerative disease Protein Type of aggregate Location References 

PD a-Synuclein Fibrillar non-amyloid Intracellular Beyer (2007), Burke (2004) 

HD Huntingtin Fibrillar non-amyloid Intracellular Bonilla (2000), Gil and Rego (2008) 

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