Musk, artificial

Synonyms Amber musk Artificial musk ambrette Benzene, 1-(1,1-dimethylethyl)-2-methoxy-4-methyl-3,5-dinitro- 5-t-Butyl-1,3-dinitro-4-methoxy-2-methylbenzene 4-t-Butyl-2,6-dinitro-3-methoxytoluene 6-t-Butyl-3-methyl-2,4-dinitroanisole 1-(1,1-Dimethylethyl)-2-methoxy-4-methyl-3,5-dinitrobenzene 2,6-Dinitro-3-methoxy-4-t-butyltoluene 2,6-Dinitro-3-methoxy-1-methyl-4-t-butylbenzene Griselimycine 1-Methyl-4-t-butyl-3-methoxy-2,6-dinitrobenzene Musk ambrette, artificial Synthetic musk ambrette Empiricai C12H16N2O5... 

It is fairly soluble in dilute alcohol, and in about 35 parts of water. It can therefore be fairly easily separated from less soluble constituents by shaking with 5 or 10 per cent, alcohol. Apart from its actual perfume value, benzyl alcohol is of considerable value to the perfumer, since it acts as a very valuable fixative, and is, moreover, one of the best-known solvents for artificial musk. 

There are a number of nitro-compounds known under the name of artificial musk, all of which may conveniently be grouped together here. The natural odorous constituents of musk appear to be, in the main, ketonic compounds free from nitrogen, so that the term artificial musk must be understood to mean artificially prepared bodies, having musklike odours, but not having any direct chemical relationship with natural musk perfume. 

The artificial musk which was the first to achieve marked success was that manufactured under the patent of Albert Baur (English patent No. 4963 of 1889). The provisional and complete specifications of this patent are as follows —... 

The process for producing artificial musk substantially as described. 

The mono- and dinitro products have no musk odour, and therefore the nitration of the hydrocarbon should be carried as far as possible. The constitution of this artificial musk, or " xylene musk as it is often called, is probablv—... 

This is the most common form of artificial musk of commerce, melts, when pure, at 110° to 113°. 

Still later Baur has shown that if an acetyl group is introduced into the butyl toluene molecule, and the methyl ketone thus formed is nitrated, artificial musk (ketone musk) is produced. One part of butyl toluene, 10 parts of carbon disulphide, and 6 parts of aluminium chloride are cooled in a flask and 6 parts of acetyl chloride are run in quickly. After distillation on a water-bath, the residue is poured on to ice and treated in the usual manner. The acetyl derivative is obtained as an oil with a pleasant aromatic odour, boiling at 255° to 258°, of the formula—... 

Musk ambrette, which is usually regarded as the finest of all the artificial musks, is a nitro-compound of the methyl ether of butyl-meta-cresol, usually described as dinitro-butyl- ieia-cresol methyl ether. It should melt at 85°. 

Some of the artificial musks of commerce are mixtures of two or more of the bodies above described, a fact which is easily demonstrated by fractionally crystallising the specimen, when the fractions will show altered melting-points. The principal adulterant of artificial musk is acetanilide. This can, of course, be easily detected by the phenyl-isocyanide reaction or by dissolving it out with hot water. 

Artificial musks are used in fragrances and perfumes, air fresheners and laundry powders. 

Uses Denaturant for ethyl alcohol manufacturing flavors, perfumes (artificial musk), flotation agents solvent paint removers octane booster for unleaded gasoline dehydrating agent chemical intermediate. 

Greenpeace (2005) TNG report Phtalates and artificial musks in perfumes. http //www. greenpeace.org/raw/content/intemational/press/reports/phthalates-and-artificial-musk.pdf... 

Musk AW, Greeville HW, Tribe AE. 1980. Pulmonary disease from occupational exposure to an artificial aluminum silicate used for cat litter. Br J Ind Med 37 367-372. 

These preliminary results seem to confirm that extracts of muskrat preputial glands and possibly also of sweet flag can indeed enhance the catches of muskrats, especially in scented funnel traps in artificial pipes at river banks, where migrating muskrats pass. The animals caught are then mainly males which preferentially enter artificial pipes scented with extracts of musk glands which - it should be remarked here - are produced by other males. 

Nitro musk (first artificial fragrance compound) A. Baur... 

The most classical artificial substances used in perfumery are as follows (Figure 5). Hydroxycitronellal (99) was found to exhibit the odor of lily of the valley, the essential oil of which is not possible to prepare in the first place. Other classics include ct-amylcinnamaldehyde (100) and musk ketone (101), which were discovered to be good substitutes for jasmine and musk, respectively. Furthermore, perfume No. 5 (Chanel, launched 1921) contained 2-methylundecanal, 1 with so unique an aroma character that it established No. 5 as the pioneer of a new fragrance class — floral aldehydic. 

Further development in synthetic chemistry in the second half of the twentieth century brought bloom to another tide of artificial fragrance materials. In terms of musk substitutes,113 122 mainly three new categories... 

This compound is known as artificial musk as it has an odor very similar to musk, and is used as a substitute for it. 

Winkler M, Kopf G, Hauptvogel C, Neu T (1998) Fate of artificial musk fragrances associated with suspended particulate matter (SPM) from the river Elbe (Germany) in comparison to other organic contaminants. Chemosphere 37, 1139-1156. 

C15H26O4, Mr 270.37, bp y kpa 140 °C, d%° 1.0180, rv 1.4702, is an artificial fragrance material, with a sweetish, slightly fatty, musk odor. Like the previous compound, the ester is obtained by depolymerization of the corresponding polyester. Traditionally, brassylic acid (1,13-tridecanedioic acid) is prepared by ozonolysis of erucic acid [208] ... 

Beilstein Handbook Reference) Aceto-phenone, 4 -t-butyl-2, 6 -dimethyl-3, 5 -dinitro- 2-Acetyl-5-l-butyl-4,6-clinitroxylene AI3-02440 BRN 2062638 4-t-Butyl-3,5-dinitro-2,6-dimethylaceto-phenone 4 -t-Butyl-2, 6 -dimethyl-3, 5 -dinitroaceto-phenone CCRIS 4677 1-(4-(1,1-Dimethylethyl)-2,6-dimethyl-i5-dinitrophenyl)-ethanone 2,6-Dinitro-3,5-di-methyl-4-acetyl-t-butyl-benzene 3, Dinitro-2,6-di-methyl-4-t-butylacetophen-one EINECS 201-328-9 Ethanone, 1-(4-(1,1-dimethyl-ethyl)-2,6-dimethyl-3,5-Musk ketone NSC 15339 Acetophenone, 4 -t-butyl-2, 6 -dimethyl-3, 5 -dinitro- 1-Acetyl-4-t-butyl-2,6-dimethyl-3,5-dinitro-benzene 4-t-Butyl-2,6-dimethyi-3,5-dinitro-acetophen-one 4 -t-Butyl-2, 6 -dimethyl-3, 5 -dinitro-acetophenone 1-[4-(1,1-Dimethylethyl)-2,6-dimethyl-3,5-dinitrophenyl]-ethanone. An artificial musk perfume. Solid mp = 138-140°. AM Aromatics Pvt, Ltd. Zhejiartg Winsun Imp. And Exp. Co., Ltd. 

Iodoform Butyric acid Propyl mercaptan Artificial musk Methyl mercaptan... 

Artichoke leaves. See Artichoke (Cyanara scolymus) leaves Artie Mist . See Talc Artificial almond oil. See Benzaldehyde Artificial ant oil. See Furfural Artificial barite. See Barium sulfate Artificial cinnabar. See Mercury sulfide (ic), red Artificial cinnamon oil. See Cinnamon (Cinnamomum cassia) oil Artificial gum. See Dextrin Artificial heavy spar. See Barium sulfate Artificial musk ambrette. See Musk ambrette... 

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