P-Cresol methyl ether

SYNS p-CRESOL methyl ether p-cresyl METHYL ETHER FEMANo. 2681 p-METHOXY-TOLUENE 4-METHOXYTOLUENE 4-METHYL-l-METHOXYBENZENE 4-METHYLPHENOL METHYL ETHER METHYL-p-TOLYL ETHER p-TOLYL METHYL ETHER... 

Acetoxymercuri-p-cresol does not yield the corresponding iodide when treated with potassium iodide, but the mercury is eliminated as mercuric iodide. Chloromercuri-p-cresol in alcoholic solution gives the anhydride of hydroxymercuri-p-cresol when a boiling sodium carbonate solution is added. The diacetoxymercuri derivative of p-cresol methyl ether is stable towards ammonium hydroxide or sulphide, but gives the chloride on the addition of aqueous sodium chloride. 

It is unaffected by aznmonium sulphide or sodium hydroxide but when its clear alcoholic solution is treated with aqueous sodium chloride, chloromercuri-p-cresol methyl ether, Me.CgH. O le.HgCl, is precipitated. This crystallises from 96 per cent, alcohol in white needles, Mq )t. 162 C., vhich are not acted upon by ammonium hydroxide, sulphide, or sodium hydroxide, although easily soluble in the latter. 

The unattacked Oil R is treated in a similar manner with fresh bisulphite. The Oil R 1 still undissolved by this second treatment is steam-distilled with the addition of 6 kilos of soda ash. p-Cresol methyl ether is recovered from the main distillate the last portions contain also some aubepine, which is added to the next batch for purification. 

The benzene extract leaves on distillation an oil from which in the same way p-cresol methyl ether and a little aubepine are recovered. 

CAS 120-71-8 EINECS/ELINCS 204-419-1 Synonyms m-Amino-p-cresol, methyl ester 3-Amino-p-cresol, methyl ether 1-Amino-2-methoxy-5-methylbenzene 3-Amino-4-methoxytoluene 2-Amino-4-methylanisole... 

Synonyms p-Cresol methyl ether p-Cresyl methyl ether Methoxy-1 methyl-4 benzene 1-Methoxy-4-methylbenzene 4-Methoxytoluene p-Methoxytoluene 4-Methylanisole Methyl p-cresol 4-Methyl-1-methoxybenzene 4-Methylphenol methyl ether Methyl-p-tolyl ether p-Tolyl methyl ether Classification Aromatic ether Empirical CsHioO... 

Preparation by reaction of 2-brcmo-5-nitrobenzoyl chloride with p-cresol methyl ether in the presence of aluminium chloride in carbon disulfide at r.L for 1 h, then in a boiling water bath for 2-4 h (78%) [719]. 

Also obtained by Friedel-Crafts acylation of p-cresol methyl ether with pheny-lacetyl chloride in the presence of aluminium chloride, first in refluxing carbon disulfide for 5 h, then, after solvent elimination, at 120-130 for 5 h (54-61%) [5314]. 

Also obtained by Friedel-Crafts acylation of p-cresol methyl ether with excess acetyl chloride in the presence of aluminium chloride [4625]. 

CICH CO JL COCH Cl Obtained (by-product) by Friedel-Crafts jT acylation of p-cresol methyl ether with... 

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