Core binding factor 1

Wang S, Crute BE, Melnikova IN, Keller SR, Speck NA. Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core-binding factor. Mol Cell Biol 1993 13 3324-3339. 

Key words leukemic stem cell, core-binding factor, differentiation, self-renewal... 

Figure I. The hetero dimeric Core Binding Factor (CBF) transcription factor is comprised of one of three RUNX family proteins (a snbnnit) and a b-subimit, which is encoded by a single gene. The RUNX proteins contain two conserved and functional domains the runt homology domain (RHD) and the transcription activation domain (TAD). Interactions between the RHD and the hetero dimerization domain (HD) of CBFb are essential for most of the known activities of CBF. Synerigistic activity with a number of different transcription factors is well established.

Boissel, N., Leroy, H., Brethon, B., Philippe, N., de Botton, S., Auvrignon, A., Raffoirx, E., Leblanc, T., Thomas, X., Hermine, 0., et al. (2006) Incidence and prognostic impact of c-Kit, FLT3, and Ras gene mutations in core binding factor acute myeloid leukemia (CBE AML). 

Cammenga, J., Horn, S., Bergholz, U., Sommer, G., Besmer, P., Fiedler, W. and Stocking, C. (2005) Extracellular KIT receptor mutants, commonly found in core binding factor AML, are constitutively active and respond to imatinib mesylate. Blood 106, 3958-3961. 

Goemans, B., Zwaan, C., Miller, M., Zimmermann, M., Harlow, A., Meshinchi, S., Loonen, A., Hahlen, K., Reinhardt, D., Creutzig, U., et al (2005) Mutations in KIT and RAS are frequent events in pediatric core-binding factor acute myeloid leukemia. Leukemia 19, 1536 1542. 

Miller, J., Horner, A., Stacy, T., Lowrey, C., Lian, J., Stein, G., Nuckolls, G. and Speck, N. (2002) The core binding factor beta subunit is required for bone formation and hematopoietic maturation. Nat Genet 22, 645-649. 

Speck, N. and Gilliland, D. (2002) Core-binding factors in haematopoiesis and leukaemia. Nat Rev Cancer 2, 502-513. 

Polyalanine repeats. Our analysis of the constraints on repeat composition revealed that long stretches of alanine residues were almost as protective as the original GAr consensus. Interestingly, expansion of polyalanine stretches in core binding factor al (Mundlos et al., 1997), HoxDIS (Muragaki et al., 1996), polyalanine binding protein-2 (Brais et al.. 

G5 BMP-12R Brachyury CBF membrane ganglioside related to pericytes identification receptor to bone morphogenetic protein isoform 12 transcription factor related to embryo mesoderm determination core-binding factor protein family involved in cell differentiation... 

Care RS, Valk PJ, Goodeve AC, Abu-Duhier FM, Geertsma-Kleinekoort WM, Wilson GA, et al. Incidence and prognosis of c-KIT and FLT3 mutations in core binding factor (CBF) acute myeloid leukaemias. Br J Haematol 2003 121 775-7. 

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