Mouse genetics

Neuro steroids, which may be physiological modulators of brain activity, enhance GABAa receptor function 297 The three-dimensional structures of ligand-gated ion channel receptors are being modeled successfully 297 Mouse genetics reveal important functions for GABAa receptor subtypes 297... 

The leptin story has been augmented by a second mouse genetic defect leading to obesity. These mice are known as db/db they are very similar to ob/ob mice. However, these mice have normal levels of leptin. Scientists at Millennium Pharmaceuticals identified the molecular defect in db/db mice. They lack the normal leptin receptor. Therefore, we have both sides of the coin ob/ob mice cannot make leptin, eat too much, and are therefore obese db/db mice make leptin, cannot respond to it for lack of the leptin receptor, eat too much, and are obese. Administration of leptin to ob/ob mice normalizes their body weight but administration of leptin to db/db mice has... 

Sharpless NE, DePinho RA (2006) The mighty mouse genetically engineered mouse models in cancer drug development. Nat Rev Drug Discov 5 741-754... 

Revealing Novel Oncology Targets and Their Validation via Mouse Genetics... 

Bucan M, Abel T (2002) The mouse genetics meets behaviour. Nat Rev Genet 3 114-123 Cahill L, McGaugh JL (1998) Mechanisms of emotional arousal and lasting declarative memory. Trends Neurosci 21 294-299... 

Rudolph U, Mohler FI Analysis of GABAA receptor function and dissection of the pharmacology of benzodiazepines and general anesthetics through mouse genetics. Annu Rev Pharmacol Toxicol 2004 44 475. [PMID 14744255]... 

Paigen, K. One hundred years of mouse genetics an intellectual history. I. The classical period (1902-1980). Genetics 163, 1-7. 

The house mouse, mus musculus, is characterized by its ability to live in close association with people. In fact, most have been dependant on human shelter and activity and have migrated along with human population for over 10,000 years. They are referred to as commensal animals because they share related food supplies. Mice like humans are omnivorous and overall are considered a good model to study the regulation of dietary intake and nutrient metabolism in humans. In addition, a wealth of information resources and experimental approaches for mouse genetics are available for the study of biological processes involved in human diseases (1). 

Danko, I., Chapman, V. and Wolff, J. A. (1992) The frequency of revertants in mdx mouse genetic models for Duchenne muscular dystrophy. Pediatr Res 32, 128-131. 

Mice were the main exception to this rule. Although research on mouse genetics didn t require larger populations, mice were, for obvious reasons, considerably more expensive than bacteria or yeast to breed, house, and study (Russell 1994). 

Additional support for nAChRs in schizophrenia largely is based on mouse genetic models. Mice heterozygous for a null mutation in Chrna7, the gene that codes for the al subunit, exhibit reduced expression of the al subunit, poor auditory gating, and other functional deficits in the hippocampus similar to those observed in schizophrenic patients (Adams et al., 2008). In addition, a naturally occurring... 

Flanagan SP. Nude/ a new hairless gene with pleiotropic effects in the mouse. Genet Res 1966 8 295-309. 

Russell, L. B., and Major, M. H. (1957). Radiation-induced presumed somatic mutations in the house mouse. Genetics 42, 161-175. 

Gerard, C. (1999). In Chemokines in Disease (ed C. A. Hebert), Understanding chemokine biology through mouse genetics riddles and answers, pp. 41-52. Humana, Totowa, NJ. 

The ability to selectively modify the genome In the mouse has revolutionized mouse genetics. Outline the procedure for generating a knockout mouse at a specific genetic locus. How can the loxP-Cre system be used to conditionally knock out a gene What Is an Important medical application of knockout mice ... 

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