Heterozygous mice

Periasamy M, Reed TD, Liu LH et al 1999 Impaired cardiac performance in heterozygous mice with a null mutation in the sarco(endo)plasmic reticulum Ca2+-ATPase isoform 2 (SERCA2) gene. J Biol Chem 274 2556—2562... 

Mayorga AJ, Dalvi A, Page ME, Zimov-Levinson S, Hen R, Lucki I (2001) Antidepressant-like behavioral effects in 5-hydroxytryptamine(lA) and 5-hydroxytryptamine(lB) receptor mutant mice. J Pharmacol Exp Ther 298 1101-1107 Mcllvain VA, Robertson DR, Maimone MM, McCasland JS (2003) Abnormal thalamocortical pathfinding and terminal arbors lead to enlarged barrels in neonatal GAP-43 heterozygous mice. J Comp Neiuol 462 252-264... 

Brooks, W.W., and Conrad, C.H. 2000. Myocardial fibrosis in transforming growth factor beta(l)heterozygous mice. J Mol. Cell. Cardiol. 32 187-195. 

Backman C, You ZB, Perlmann T, Hoffer BJ (2003) Elevated locomotor activity without altered striatal dopamine contents in Nurrl heterozygous mice after acute exposure to methamphetamine. Behav Brain Res 743 95-100. 

D. L. Coleman, Obesity genes beneficial effects in heterozygous mice. Science, 203, (4381), 663-665, 1979. 

Kulkarni RN, Almind K, Goren HJ, et al. Impact of genetic background on development of hyperinsulinemia and diabetes in insulin receptor/insulin receptor substrate-1 double heterozygous mice. Diabetes. 2003 52 1528-1534. 

The consequences of altered neurotransmission in SERT-KO mice on the responsiveness of 5-HT receptors have been extensively documented. In electro-physiological studies (91), a marked desensitization of both pre- and postsynaptic 5-HT 1A receptors was found in SERT-KO mice, whereas only presynaptic receptors were affected in the heterozygous mice. Accordingly, 5-HT 1A binding... 

---