Mouse genetic markers

Kuettner, M.G., Wang, A.-L., Nisonoff, A. (1972). Quantitative investigations of idiotypic antibodies. VI. Idiotypic specificity as a potential genetic marker for the variable regions of mouse immunoglobulin polypeptide chains. J. Exp. Med.135,579-595. 

Refer Guidelines for Nomenclature of Genes, Genetic Markers, Alleles, and Mutations in Mouse and Rat at the Mouse Genome Informatics (MGI) website (http //www. informatics.jax.org/mgihome/nomen/gene.shtml) and Zebrafish Nomenclature Guidelines at the ZFIN website (http //zfin.org/zf info/nomen.html). 

Benton, C.S., MUler, B.H., Skwerer, S., Suzuki, O., Schultz, L.E., Cameron, M.D., Matron, J.S., Fletcher, M.T., Wiltshire, T., 2012. Evaluating genetic markers and neurobiochemical analytes for fluoxetine response using a panel of mouse inbred strains. Psychopharmacology (Berl) 221, 297-315. 

Nearly all allotypic determinants studied in the mouse have been found on H chains (198,201-206). (A k chain genetic marker will be described below.) With the exception of two specificities recently dis-... 

There are literally hundreds of markers that are currently available for the mouse and human than can be used to characterize lymphoid and myeloid cells and subsets in primary and secondary lymphoid organs. Many of the markers expressed in mammals are highly conserved across species and have been designated as genetic clusters of differentiation (CD). CDs can be identified with fluorescently labeled monoclonal antibodies. As presented previously, when combined with other fluorescent probes, important information on intracellular biochemistry and cell function can be obtained. Many of the biochemical markers used by immunotoxicologists are common to other... 

Gene transfer of mouse and human CD34+ HSCs, which were genetically modified by a retroviral virus encoding ADA cDNA and the neomycin-resistance marker gene, have been extensively characterized in mouse models without reports of toxicity. Furthermore, none of the preclinical studies for ADA-SCID have demonstrated evidence of cancer in animals treated with this same gene transfer approach [515137], [666652], [666655]. 

Markel P, Shu P, Ebeling C, Carlson GA, Nagle DL, Smutko JS, Moore KJ Theoretical and empirical issues for marker-assisted breeding ofcongenic mouse strains. Nat Genet 17 280-284,1997... 

Mouse 1,000-90,000 AG, CP, LD, AM + Genetic manipulation + Molecular markers - Low sensitivity - Inter-strain differences - Immature explants... 

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