Other functions of IgG

The molecular mechanisms by which IgG is removed from the circulation are referred to as clearance. The number, nature and relative importance of the molecular species interacting with IgG in this process are unclear as is the nature of damaged or altered IgG subject to clearance. However, it is apparent that the Ch2 domain is critical in control of clearance [25]. 

A number of immune responses including polyclonal antibody production, T-cell responses such as antigen and alloantigen-induced proliferation and cell-mediated 

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