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Genetically Modified Mouse Models

Cancer susceptibility is determined by complex interactions between age, environment, and an individual s genetic make-up. The basis for understanding individual susceptibility to cancer will likely come from characterizing gene-environment interactions and the role of SNPs in both coding and promoter regions of certain [Pg.585]

Eleventh Report on Carcinogens, U.S. Department of Health and Human Services, Public Health Service, National Toxicology Program 2005 (www.niehs.nih.gov). [Pg.586]

Overall evaluations of carcinogenicity to humans. International Agency for Research on Cancer (IARC) (www.iarc.fr). [Pg.586]

Vogelstein, B., and Kinzler, K. W. Cancer Genes and the Pathways they Control. Nature Med. 10, 789-799, 2004. [Pg.586]

Weinberg, R. A. The Biology of Cancer, Garland Science, Taylor and Francis Group, New York, 2007. [Pg.586]

Ambartsumian N, Grigorian M, Lukanidin E. 2005. Genetically modified mouse models to study the role of metastasis-promoting S100A4(mtsl) protein in metastatic mammary cancer. J Dairy Res 72 Spec No 27-33. [Pg.123]

Comprehensive Phenotyping of Genetically Modified Mouse Models... [Pg.44]

Genetically modified mouse models of human disease have proven invaluable in deepening our understanding of the molecular, cellular, and physiological events that underlie human diseases. Developing... [Pg.251]

The role of genetically modified mouse models in predictive toxicology... [Pg.269]

Recio L and Everitt J (2001) Use of genetically modified mouse models for evaluation of carcinogenic risk Consideration for the laboratory animal scientist. Comparative Medicine 51 399—405. [Pg.275]

A detailed protocol for the generation of genetically modified human xenograft mouse models in which the knockdown of a putative oncology target is temporally regulated in vivo using a tetracycline inducible system is found in this book (17). [Pg.284]

Gene transfer of mouse and human CD34+ HSCs, which were genetically modified by a retroviral virus encoding ADA cDNA and the neomycin-resistance marker gene, have been extensively characterized in mouse models without reports of toxicity. Furthermore, none of the preclinical studies for ADA-SCID have demonstrated evidence of cancer in animals treated with this same gene transfer approach [515137], [666652], [666655]. [Pg.81]

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