Genetically engineered mice models

Sharpless NE, DePinho RA (2006) The mighty mouse genetically engineered mouse models in cancer drug development. Nat Rev Drug Discov 5 741-754... 

Modulation of Cancer Gene Candidates in Genetically Engineered Mouse Models(GEMMs)... 

Singh M, Johnson L (2006) Using genetically engineered mouse models of cancer to aid drug development an industry perspective. Clin Cancer Res 12 5312-5328... 

Heyer J, Kwong LN, Lowe SW et al (2010) Non-germline genetically engineered mouse models for translational cancer research. Nat Rev Cancer 10 470-480... 

Huijbers IJ, Krimpenfort P, Berns A et al (2011) Rapid validation of cancer genes in chimeras derived from established genetically engineered mouse models. Bioessays 33 701-710... 

Sacca R, Engle SJ, Qin W et al (2010) Genetically engineered mouse models in drug... 

Genetically Engineered Mouse Models in Drug Discovery Research... 

In this section, we have tried to review a broad cross-section of genetically engineered mouse models and some specific... 

Although not strictly a genetically engineered mouse model, mice have been developed in which mouse hepatocytes have been replaced by human hepa-tocytes. These mice have been used for metabolism and toxicity testing,65-69 although perhaps their most valuable application is for focused mechanistic in vivo studies. 

E.D. Abel, Insulin signaling in heart muscle lessons from genetically engineered mouse models, Curr. Hypertens. Rep. 6,416-423 (2004). 

Powley, M.W. et al., Safety assessment of drug metabolites Implications of regulatory guidance and potential application of genetically engineered mouse models that express human P450s, Chem. Res. Toxicol., 22(2), 257, 2009. 

Linder, CC, The influence of genetic background on spontaneous and genetically engineered mouse models of complex diseases. Lab Anim (NY), 2001. 30(5) 34—39. 

Kwak 1, Tsai S Y, DeMayo FJ. Genetically engineered mouse models for lung cancer. Annu Rev Physiol 2004 66 647-663. 

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