Molecularly imprinted polymers nanoparticles

Synthesis and Characterisation of Molecularly Imprinted Polymer Nanoparticles for Streptomycin for Use as Solid Phase Extraction Materials... 

Y. Hoshino, H. Koide, T. Urakami, H. Kanazawa, T. Kodama, N. Oku, et at. Recognition, neutralization, and clearance of target peptides in the bloodstream of living mice by molecularly imprinted polymer nanoparticles a plastic antibody, /. Am. Chem. Soc., 2010, 132(19), 6644-6645. 

Molecular Imprinted Polymer Nanoparticles for Ofloxacin Determination... 

A. Poma, A. Guerreiro, M.J. Whitcombe, E.V. Piletska, A.P.F. Turner, and S.A. Piletsky, Solid-phase synthesis of molecularly imprinted polymer nanoparticles with a reusable tem-plate- Plastic antibodies, Adv. Funct. Mater., 23,2821-2827,2013. 

E Tan, D. Sun, J. Gao, Q. Zhao, X. Wang, F. Teng, X. Quan, and J. Chen, Preparation of molecularly imprinted polymer nanoparticles for selective removal of fluoroquinolone antibiotics in aqueous solution, /. Hazard. Mat., 244-245, 750-757, 2013. 

S. Azodi-Deilami, M. Abdouss, D. Kordestani and Z. Shariatinia, Preparation of N,N-p-phenylene bismethacryl amide as a novel cross-link agent for synthesis and characterization of the core-shell magnetic molecularly imprinted polymer nanoparticles, /. Mater. Sci. Mater. M., 25 (3) 645-656, 2014. 

E. Asadi, S. Azodi-Deilami, M. Abdouss, D. Kordestani, A. Rahimi and S. Asadi, Synthesis, recognition and evaluation of molecularly imprinted polymer nanoparticle using miniemulsion polymerization for controlled release and analysis of risperidone in human plasma samples, Korean /. Chem. Eng., 31 (6) 1028-1035,2014. 

Chianella, A. Guerreiro, E. Moczko, J.S. Caygill, E.V. Piletska, hnpd Sansalvador, M.J. Whitcombe and S.A. Piletsky, Direct replacement of antibodies with molecularly imprinted polymer nanoparticles in ELIS A-development of a novel assay for vancomycin. Anal. Chem., 85 (17) 8462-8468,2013. 

S. Korposh, I. Chianella, A. Guerreiro, S. Caygill, S. Piletsky, S.W. lames and R.P Tatam, Selective vancomycin detection using optical fibre long period gratings functionalised with molecularly imprinted polymer nanoparticles, Ana/ysf, 139 (9) 2229-2236, 2014. 

Metal nanoparticles have also been included into MIPs. Such particles can be used, for example, as nanoantennae for the enhancement of electromagnetic waves (plasmonic enhancement). It has been shown by He et al. [122] that a thin layer (20-120 nm) of testosterone-imprinted silica could be synthesized around 350 nm silver particles in a controlled way. The composite material showed specific binding of the testosterone target. Matsui et al. [123] reported a molecularly imprinted polymer with immobilized Au nanoparticles as a sensing material for spectrometry. The sensing mechanism is based on the variable proximity of the Au nanoparticles... 

Fig. 12 (a) Schematic representation of the preparation of a molecularly imprinted polymer with immobilized Au nanoparticle and the detection of an analyte upon selective swelling of the MIP. Reprinted with permission from [123]. Copyright (2004) American Chemical Society, (b) Schematic representation of Au-MIP/MIP-coated SPR sensor chip. Reprinted with permission from [124]. Copyright (2005) American Chemical Society... 

Nanobarcodes Nanoemulsions Nanofibers Nanoparticles Nanoshells Carbon nanotubes Quantum dots Artificial binding sites Artificial antibodies Artificial enzymes Artificial receptors Molecularly imprinted polymers Cell simulations and cell diagnostics Cell chips Cell stimulators... 

Matsui, J., Akamatsu,K., et al. SPR Sensor Chip for Detection of Small Molecules Using Molecularly Imprinted Polymer with Embedded Gold Nanoparticles. "Analytical Chemis-try,77(13), 4282 285 (2005). 

With the development of nanosized adsorbents, it may become more important to pack these nanoparticles such that they can be used conveniently. Cryogels offer an interesting alternative for this. Molecular imprinted polymers will be discussed later in Sect. 11. 

Huang JD, Zhang XM, Liu S, Lin Q, He XR, Xing XR, Lian WJ (2011) Electrochemical sensor for bisphenol A detection based on molecularly imprinted polymers and gold nanoparticles. J Appl Electrochem 41 1323... 

Kan, X. Liu, T. Zhou, H Li, C. Fang, B. (2010). Molecular imprinting polymer electrosensor based on gold nanoparticles for theophylline recognition and determination. Microchimica Acta, 171,423-429. 

Although the first report on boronic acids was published in 1862, boronate affinity materials have not been extensively investigated until recently. In recent years, various boronate-functionalized materials, " such as macroporous monoliths, " " nanoparticles, and mesoporous materials, have been developed into important tools for the facile selective extraction of cis-diol-containing compounds. With these matrices, several important materials with teamed boronate affinity and boronate avidity as well as boronate affinity-based molecularly imprinted polymers have been prepared. 

C. Xue, Q. Han, Y. Wang, J.H. Wu, T.T. Wen, R.Y. Wang, J.L. Hong, X.M. Zhou and H.J. Jiang, Amperometric detection of dopamine in human serum by electrochemical sensor based on gold nanoparticles doped molecularly imprinted polymers. Biosens. Bioelectron., 49 199-203, 2013. 

H.M. Zhao, Y.Q. Chen, J.P. Tian, H.T. Yu and X. Quan, Selectively electrochemical determination of chloramphenicol in aqueous solution using molecularly imprinted polymer-carbon nanotubes-gold nanoparticles modified electrode, J. Electrochem. Soc., 159 (6) J231-J236, 2012. 

W.J. Lian, S. Liu, J.H. Yu, X.R. Xing, J. li, M. Cui and J.D. Huang, Electrochemical sensor based on gold nanoparticles fabricated molecularly imprinted polymer film at chitosan-platinum nanoparticles/graphene-gold nanoparticles double nanocomposites modified electrode for detection of erythromycin, BfoscHs. Bioelectron., 38 (1) 163-169,2012. 

T. Alizadeh, M.R. Ganjali and M. Akhoundian, Fabrication of an extra sensitive voltam-metric sensor using nanoparticles of molecularly imprinted polymer for determination of ultra-trace promethazine in plasma sample, Int. J. Electrochem. Sci., 7(11) 10427-10441, 2012. 

H.T. Wang, H.M. Zhao, X. Quan and S. Chen, Electrochemical determination of tetracy-chne using molecularly imprinted polymer modified carbon nanotube-gold nanoparticles electrode. Electroanalysis, 23 (8) 1863-1869, 2011. 

Shea and colleagues [109-111] added an exciting contribution to this field They created molecular imprints for the peptide melittin, the main component of bee venom, in polymer nanoparticles, resulting in artificial antibody mimics that can be used for the in vivo capture and neutralization of melittin. Melittin is a peptide comprising 26 amino acids which is toxic because of its cytolytic activity. Shea and colleagues strategy was to synthesize cross-linked, acrylamide-based MIP nanoparticles by a process based on precipitation polymerization using a small amount of surfactant. To maximize the specificity and the affinity for melittin, a number of hydrophilic monomers were screened for complementarity with the template. The imprinted nanoparticles were able to bind selectively the peptide with an apparent dissociation constant of Ax>app > 1 nM [109]. 

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