Theophylline recognition

In pharmaceutical fields, in Zhang Z. et al., 2010b, a novel sensitive and selective imprinted electrochemical sensor was constructed for the direct detection of L-histidine by combination of a molecular imprinting film and MWNTs. The sensor was fabricated onto an indium tin oxide electrode via stepwise modification of MWNTs and a thin film of MIPs via sol-gel technology. The introduced MWNTs exhibited noticeable enhancement on the sensitivity of the MIPs sensor, meanwhile, the molecularly impainted film displayed high sensitivity and excellent selectivity for the target molecule. H. Y. Lee Kim, 2009 reports of the synthesis of CNTs-MIP composite to be potentially applied to probe materials in biosensor system for theophylline recognition based on CNT field effect. Hydroxyl-... 

Kan, X. Liu, T. Zhou, H Li, C. Fang, B. (2010). Molecular imprinting polymer electrosensor based on gold nanoparticles for theophylline recognition and determination. Microchimica Acta, 171,423-429. 

NoreU MC, Andersson HS, Nicholls lA. Theophylline molecularly imprinted polymer dissociation kinetics a novel sustained release drug dosage mechanism. J Mol Recognit 1998 11 98-102. 

MIP membranes were prepared for the recognition of water soluble L-glutamine [218], tetracycline [221], uric acid [223], theophylline [216, 222] and naringin... 

Several authors have compared imprinted polymers to biological receptors and even the term plastic antibodies has been coined to describe these remarkable materials. To a large extent, this comparison rests on a spectacular work of Mosbach and co-workers [24], who showed that theophylline- and diazepam-imprinted polymers displayed a specificity rather similar to that of polyclonal antibodies in binding studies with the template and its close structural analogues. However, it is the recognition of nucleotide or oligopeptide sequences which is... 

Cai LS, Wu CY, Mei SR, Zeng ZR (2004) Molecularly imprinted polymer theophylline retention and molecular recognition properties in capillary electrochromatography. Wuhan Univ J Natl Sci 9(3) 359-365... 

Figure 7.8 A schematic representation of the preparation of molecularly imprinted polymers [19]. (a) Functional monomer MAA (1) is mixed with print molecule, here theophylline (2), and EDMA, the cross-linking monomer, in suitable solvent. MAA is selected for its ability to form hydrogen bonds with a variety of chemical functionalities of the print molecule. (6) The polymerization reaction is started by addition of initiator (2,2 -azobis(2-methylpropionitrile), AIBN). A rigid insoluble polymer is formed, Imprints , which are complementary to the print molecule in both shape and chemical functionality, are now present within the polymeric network, (c) The print molecule is removed by solvent extraction. The wavy line represents an idealized polymer structure but does not take into account the accessibility of the substrate to the recognition site,...

The molecular recognition capabilities of polyelectrolyte multilayers have also been investigated by Laschewesky [55], while imprinted films have been grown on membrane surfaces in approaches similar to the phase inversion method for preparing a membrane imprinted with theophylline. Wang et al. [56] adopted an acrylonitri-le/dithiocarbamoyl-methylstyrene copolymer (Fig. 16) to effect separation of caffeine from the theophylline-imprinted membrane. 

Fig. 20 S ilicon wafer surface graphted with an azobenzene derivative, for photoresponsive molecular "imprinting->extracting->uptaking->shuffling" cycles, mediated by recognition of azobenzene by CD-template (theophylline, TPE) conjugates. Reproduced with permission from ref. 101. Copyright 2013 American Chemical Society.

M.G. Norell, H.S. Andersson, LA. Nicholls, Theophylline molecularly imprinted polymer dissociation kinetics A novel mechanism sustained release drug dosage, /Mol Recognit, 11, 98-102, 1998. 

CNTs) with theophylline as the template molecule [78] and from porous silica beads with thiabendazole as the print molecule [79], and these have been applied as molecular recognition agents. Qin et al. [80] made use of the stability of the dithiocarbamyl radicals generated upon photoactivation of iniferters to synthesize lysozyme-imprinted hydrophilic MlPs. These were created by Sl-lMP of acrylamide and N,N -methylenebisacrylamide from iniferter-derivatized mesoporous polystyrene beads (in the presence of the template protein lysozyme) and used in chromatographic separations that employed an aqueous mobile phase. They found that the control and stability imparted by Sl-lMP are crucial elements that enhance the separation of lysozyme from other competing proteins. 

---