Boronate Affinity Materials

Boronate Affinity Materials for the Selective Capture ofcis-Diol-Containing Biomolecules... 

Table 11.1 Strategies for manipulating the selectivity of boronate affinity materials.

Interaction type Changing boronate affinity materials Changing binding buffer composition... 

Thus, capture of czs-diol-containing biomolecules, especially glycoproteins, of very low concentration by conventional boronate affinity materials is rather difficult or impossible. Therefore, it is essential to develop novel boronic acids ligands or boronate affinity materials that can significantly improve the binding strength. 

Although the first report on boronic acids was published in 1862, boronate affinity materials have not been extensively investigated until recently. In recent years, various boronate-functionalized materials, " such as macroporous monoliths, " " nanoparticles, and mesoporous materials, have been developed into important tools for the facile selective extraction of cis-diol-containing compounds. With these matrices, several important materials with teamed boronate affinity and boronate avidity as well as boronate affinity-based molecularly imprinted polymers have been prepared. 

In addition to the conventional boronate affinity materials for pH-con-trolled captu re-release of c/s-diol-containing compounds, thermally responsive boronate affinity materials have recently attracted attention for their applications in separation science and biomedicine. For example, Deng and... 

Although it has already been more than 40 years since boronate affinity material first appeared in 1970, boronate affinity materials had not found wide applications before 2006. The most important application before 2006 was the selective isolation of glycated hemoglobin for the clinic diagnosis of diabetic mellitus. However, boronate affinity materials have gained rapid and deep development since 2006. Because fundamental issues of boronate... 

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