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Molecular determination

Monyer H, Jonas P, Rossier J (1999) Molecular determinants controlling functional properties of AMPARs and NMDARs in the mammalian CNS, chapter 9 Ionotropic glutamate receptors in the CNS. Springer Verlag... [Pg.661]

Ragsdale DS, McPhee JC, Scheuer T et al (1994) Molecular determinants of state-dependent block ofNa + channels by local anesthetics. Science 265 1724-1728... [Pg.703]

Physiologic stress evokes a molecular response essential to protecting the human body from cellular injury and death. Over the last two decades, molecular determinants of cellular responses to stress have become better understood, as well as their relationship to human health, development, aging, and disease. Molecular re-... [Pg.411]

Suhre WM, Ekins S, Chang C, Swaan PW and Wright SH. Molecular determinants of substrate/inhibitor binding to the human and rabbit renal organic cation transporters hOCT2 and rbOCT2. Mol Pharmacol 2005 67 1067-77. [Pg.512]

Rizzuto R, Pozzan T (2006) Microdomains of intracellular Ca + molecular determinants and functional consequences. Physiol Rev 86 369-408 Rojo EE, Eernandez JA, Maccioni AA, Jimenez JM, Maccioni RB (2008) Neuroinflammation imphcations for the pathogenesis and molecular diagnosis of Alzheimer s disease. Arch Med Res 39 1-16... [Pg.297]

Siebenga, J. J., Lemey, P., Kosakovsky Pond, S. L., Rambaut, A., Vennema, H., and Koopmans, M. (2010). Phylodjmamic reconstruction reveals norovirus GII.4 epidemic expansions and their molecular determinants. PLoS Pathog. 6, el000884. [Pg.36]

Fig. 4.1 Topological organization of the vanilloid receptor TRP VI. Highlighted are the molecular determinants of TRPVl regulation, such as recognition (binding) domains for capsaicin and acids, and phosphorylation sites for protein kinases. Numbers designate the key amino acid residues deduced from the rTRPVl primary sequence. Adapted from Ferrer-Montaniel, A. et al. (2004) Fur. J. Biochem. 271, 1820—1826. Fig. 4.1 Topological organization of the vanilloid receptor TRP VI. Highlighted are the molecular determinants of TRPVl regulation, such as recognition (binding) domains for capsaicin and acids, and phosphorylation sites for protein kinases. Numbers designate the key amino acid residues deduced from the rTRPVl primary sequence. Adapted from Ferrer-Montaniel, A. et al. (2004) Fur. J. Biochem. 271, 1820—1826.
Ai HW, Olenych SG, Wong P, Davidson MW, Campbell RE (2008) Hue-shifted monomeric variants of Clavularia cyan fluorescent protein identification of the molecular determinants of color and applications in fluorescence imaging. BMC Biol 6 13. doi 10.1186/1741-2007-1186-1113... [Pg.382]

Weinstein, H., R. Osman, S. Topiol, and J. R Green. 1981b. A Quantum Chemical Studies on Molecular Determinants for Drug Action. Ann. N. Y. Acad. Sci. 367, 434. [Pg.84]

Molecular determinants of recognition for the intestinal peptide carrier, J. Pharm. Sci. 1997, 86, 596-602. [Pg.442]

Tab. 2.3 Molecular determinants of microbial pathogenesis and host response... Tab. 2.3 Molecular determinants of microbial pathogenesis and host response...
Microbial virulence is often the outcome of the complex interactions that take place as the pathogen establishes itself in the human host. The molecular determinants of pathogenicity include factors that cause damage to the host cell and those that help the microbe establish productive infection for survival [35]. The human host immune response counters the presence of these microbes with its acquired or innate immune response arsenal with outcomes that range from acute to chronic or latent infections. A clear definition of the host and microbial... [Pg.20]

This essential property of IF2 can be tested in at least three different ways, all of which require the availability of f[3H]Met-tRNA and IF2, which are prepared according to the protocol detailed in Milon et al. (2007). However, all the tests described in this section can make use of the sturdier and smaller C domain of Bacillus stearothermophilus IF2, since this domain contains all molecular determinants for the IF2-fMet-tRNA interaction (Guenneugues et al, 2000 Spurio et al, 2000). The method for the preparation and purification of B. stearothermophilus IF2C is essentially that described by Spurio et al. (1993). The concentration of the protein... [Pg.293]

Because of the large number of chemicals of actual and potential concern, the difficulties and cost of experimental determinations, and scientific interest in elucidating the fundamental molecular determinants of physical-chemical properties, considerable effort has been devoted to generating quantitative structure-property relationships (QSPRs). This concept of structure-property relationships or structure-activity relationships (QSARs) is based on observations of linear free-energy relationships, and usually takes the form of a plot or regression of the property of interest as a function of an appropriate molecular descriptor which can be calculated using only a knowledge of molecular structure or a readily accessible molecular property. [Pg.14]

In this study, identification of the critical atomic and molecular determinants pertaining to the mechanism of dihydrofolate to tetrahydrofolate reduction was achieved by (i) ab initio quantum mechanics, (ii) molecular mechanics, and (iii) free energy perturbation techniques. For the first time, the complete free energy profile was calculated for the proton transfer from Asp27 of the enzyme E. Coli DHFR to the N5 position of the dihydropterin moiety of the substrate dihydrofolate. In addition, the free... [Pg.278]

Marcus, J. and Popko, B. Galactolipids are molecular determinants of myelin development and axo-glial organization. Biochim. Biophys. Acta 1573,406-413,2002. [Pg.70]

Shang Y, Brown M (2002) Molecular determinants for the tissue specificity of SERMs. Science 295 2465... [Pg.61]

Grese TA, Sluka JP, Bryant HU, Culhnan GJ, Glasebrook AL, Jones CD, Matsumoto K, Palkowitz AD, Sato M, Termine JD, Winter MA, Yang NN, Dodge JA (1997) Molecular determinants of tissue selectivity in estrogen receptor modulators. Proc Natl Acad Sci USA 94(25) 14105—14110... [Pg.297]

Rosemond, E., Peltekova, V., Naples, M., Thpgersen, H and Hampson, D. R. (2002) Molecular determinants of high affinity binding to group III metabotropic glutamate receptors. J. Biol. Chem. 277,7333-7340. [Pg.77]

Boudin, H. and Craig, A. M. (2001) Molecular determinants for PICK1 synaptic aggregation and mGluR7a receptor coclustering role of the PDZ, coiled-coil, and acidic domains. J. Biol. Chem. 276, 30270-30276. [Pg.81]

Green, J. P., Johnson, C. L., Weinstein, H., Kang, S., and Chou, D. (1978) Molecular determinants for interaction with the LSD receptor Biochemical studies and quantum chemical analysis. In The Psychopharmacology of Hallucinogens, edited by R. C. Stillman and R. E. Willette, pp. 28-60. Pergamon Press, New York. [Pg.75]

Salmona, M., Malesani, P., De Gioia, L., Gorla, S., Bruschi, M., Molinari, A., Della Vedova, F., Pedrotti, B., Marrari, M. A., Awan, T., Bugiani, O., Forloni, G., et at. (1999). Molecular determinants of the physicochemical properties of a critical prion protein region comprising residues 106-126. Biochem.J. 342, 207-214. [Pg.213]

Halverson, K., Fraser, P. E., Kirschner, D. A., and Lansbury, P. T., Jr. (1990). Molecular determinants of amyloid deposition in Alzheimer s disease Conformational studies of synthetic beta-protein fragments. Biochemistry 29, 2639-2644. [Pg.276]

Crebelli, R., Andreoli, C., Carere, A., Conti, L., Crochi, B., Cotta-Ramusino, M., Benigni, R. Toxicology of halogenated aliphatic hydrocarbons Structural and molecular determinants for the disturbance of chromosome segregation and the induction of lipid peroxidation. Chem. Biol. Interact. 1995, 98, 113-129. [Pg.501]

Guo, J., Gang, H. and Zhang, S. (2006) Molecular determinants of cocaine block of human ether-a-go-go-related gene potassium channels. The Journal of Pharmacology and Experimental Therapeutics, 317, 865-874. [Pg.80]

Lees-Miller, J.P., Duan, Y., Teng, G.Q. and Duff, H.J. (2000) Molecular determinant of high affinity dofetilide binding to hERGl expressed in Xenopus oocytes involvement of S6 sites. Molecular Pharmacology, 57, 367-374. [Pg.105]

Witchel, H.J., Dempsey, C.E., Sessions, R.B., Perry, M., Milnes, J.T., Hancox, J.C. and Mitcheson, J.S. (2004) The low-potency, voltage-dependent HERG blocker propafenone-molecular determinants and drug trapping. Molecular Pharmacology, 66, 1201—... [Pg.105]

Kamiya, K., Niwa, R., Mitcheson, J.S. and Sanguineth, M.C. (2006) Molecular determinants of HERG channel block. Molecular Pharmacology, 69, 1709-1716. [Pg.106]

Ficker, E., Jarolimek, W. and Brown, A. M. (2001) Molecular determinants of inactivation and dofetilide block in efher-a-go-go (EAG) channels and EAG-related K+ channels. Molecular Pharmacology, 60, 1343-1348. [Pg.107]

Sanchez-Chapula, J.A., Navarro-Polanco, R.A., Culberson, C., Chen, J. and Sanguinetti, M.C. (2002) Molecular determinants of voltage dependent human ether-a-go-go related gene (hERG) K1 channel block. The Journal of Biological Chemistry, TJ1. 23587—23595. [Pg.107]


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AMBER molecular structure determination

Ab Initio Molecular Dynamics for Determination of Structures and their Temperature Behavior

Activation molecular determination

Agarose gels molecular weight determination

An experimental determination of the polarization and molecular electric dipole moments

Anharmonic molecular force fields determination

Apparatus for determination of molecular weight by colligative methods

Application of Dipole Measurement in Determining Molecular Structure

Biogenic amines molecular determinants

Biomolecule Molecular Weight Determination

Biopolymers molecular weight determination

Butadiene molecular orbitals determined

Capillary electrophoresis molecular mass determination

Capillary sieving electrophoresis protein molecular weight determination

Centrifugation molecular weight determinations

Chitosan molecular mass determination

Classification of the Methods for Molecular-Weight Determination

Coagulation molecular weight determination

Conformational analysis, molecular structure determination

Determinant Huckel molecular orbital method

Determination of Empirical and Molecular Formulas

Determination of Molecular Mass

Determination of Molecular Mass by SDS-PAGE

Determination of Molecular Polarizability Anisotropy and Orientational Order from Birefringence Data

Determination of Molecular Properties

Determination of Molecular Weight and Second Virial Coefficient

Determination of Molecular Weight in Emulsion Polymerization

Determination of Molecular-Weight Distribution by Fractionation

Determination of Phosphorus via PO Molecular Absorption Lines

Determination of Polymer Molecular Dimensions from Viscosity

Determination of a Molecular Formula

Determination of absolute molecular mass

Determination of chemical composition and molecular microstructure

Determination of low-molecular-weight alkyl sulphate

Determination of molecular

Determination of molecular formula

Determination of molecular masses from multicharged ions

Determination of molecular packing

Determination of molecular point groups

Determination of molecular weight distribution

Determination of number-average molecular

Determination of number-average molecular weights

Determination of polymer transitions and investigations into molecular structure

Determination of the Molecular Formula by Mass Spectrometry

Determination of the Number-Average Molecular Weight

Determination of weight-average molecular

Determination of weight-average molecular weights

Determining the Molecular Formula

Differential molecular weight distribution determination

Dimensions, direct determination molecular

Direct Determination of Molecular Dimensions

Ebullioscopic determinations molecular weight

Electronic molecular nonlinear optical determination

Electrophoresis molecular mass determination

Electrospray interface molecular weight determination

Elemental Analysis Determining Empirical and Molecular Formulas

Elemental analysis molecular weight determination

Entanglement molecular weight determination from plateau

Experiment 4 Determination of Molecular Mass by Freezing-Point Depression

Experimental Determination of Molecular Structure

Experimental Determination of the Molecular Constants

Experimental determination molecular structure

Field-flow fractionation molecular weight determination

Formulas, molecular, determination

Gas-phase Molecular Structures Determined by Electron Diffraction

Glucan molecular weight determination

Glycosides molecular weight determination

Hemicelluloses molecular-weight determination

Homopolymer molecular weights, determination

How Do We Determine Molecular Energies

Human tissue molecular determinants

Hyaluronic acid molecular weight determination

In molecular mass determination

In molecular weight determination

Indexes molecular weight determination

Instrumentation for Molecular Weight Determination

Introduction molecular structure determination

Lewis structures molecular shape determination

Liquid molecular weight determination

Localized molecular orbitals anionic group, determination

Mass spectrometry determining protein molecular weight

Mass spectrometry molecular formula determination

Mass spectrometry molecular formula, determining

Mass spectrometry molecular weight determination

Mass spectroscopy determining molecular formulas with

Mass spectroscopy molecular weight determinations

Melting points molecular-weight determination

Membrane osmometry, determination number-average molecular

Methods for molecular weight determination

Molar mass molecular formula determination

Molar mass molecular formula determination from

Molecular Imprinted Polymeric Membrane on a Porous Silica-Gel for Norfloxacin Determination

Molecular Interactions Determining the Partitioning of Organic Compounds Between Different Phases

Molecular Mass Determination of Oligonucleotides

Molecular Structures of Phosphazenes Determined by -Ray Diffraction Methods

Molecular Weight Determination of Small

Molecular cohesion determinations

Molecular determinant

Molecular determinant

Molecular determination disruption

Molecular determination interactions

Molecular displacements determination

Molecular distribution experimental determination

Molecular formula determining

Molecular formula, determination by mass

Molecular formula, determination by mass spectrometry

Molecular formulas, using mass spectroscopy determine

Molecular geometries (determination

Molecular mass determination

Molecular mass determination by means of size-exclusion chromatography

Molecular mass, determination Gaussian

Molecular mass, determination boiling-point method

Molecular mass, determination distribution

Molecular mass, determination examples

Molecular mass, determination freezing-point method

Molecular mass, determination number average

Molecular mass, determination osmotic-pressure method

Molecular mass, determination polydispersity

Molecular mass, determination reaction, step

Molecular mass, determination vapor-pressure method

Molecular mass, determination weight average

Molecular mechanics determination

Molecular orbital energy, experimental determination

Molecular orbital theory, single-determinant

Molecular orbitals determination

Molecular parameters, determined from Zimm

Molecular parameters, polymers, determination

Molecular point group determination

Molecular shape determination

Molecular shape determining

Molecular similarities determination

Molecular size, determining from

Molecular size, determining from viscosity

Molecular speed determination

Molecular structure determination

Molecular structure determines properties

Molecular structure determines properties principle)

Molecular structure determining

Molecular structure, determination from

Molecular structure, determination from mass spectra

Molecular surface area determination

Molecular weigh! determination

Molecular weight averages determination

Molecular weight determination

Molecular weight determination Light scattering)

Molecular weight determination branched copolymers

Molecular weight determination by cryoscopy

Molecular weight determination by end-group analysis

Molecular weight determination by gel filtration

Molecular weight determination by gel permeation chromatography

Molecular weight determination by light scattering

Molecular weight determination by mass spectrometry

Molecular weight determination by sedimentation equilibrium

Molecular weight determination by vapor pressure osmometry

Molecular weight determination colligative property measurement

Molecular weight determination cryoscopy

Molecular weight determination dilute solution light scattering

Molecular weight determination early results

Molecular weight determination ebulliometry

Molecular weight determination elastomers

Molecular weight determination electrophoresis

Molecular weight determination light-scattering method

Molecular weight determination membrane osmometry

Molecular weight determination method

Molecular weight determination nucleic acids

Molecular weight determination of

Molecular weight determination polyethylene

Molecular weight determination polymolecularity

Molecular weight determination polyurethane

Molecular weight determination procedure

Molecular weight determination vapor-phase osmometry

Molecular weight determination viscometry

Molecular weight determination viscosity

Molecular weight determination, drinking

Molecular weight determination, oxidized

Molecular weight determination, polymers osmotic pressure method

Molecular weight determination, polymers viscometric method

Molecular weight determination, starch

Molecular weight determining

Molecular weight determining formula from

Molecular weight determining from

Molecular weight determining from light

Molecular weight distribution, cellulosic fibers, determination

Molecular weight distributions determining

Molecular weight, Calculation Determination

Molecular weight, determination calibration curve

Molecular weight, mass spectral determination

Molecular weight, spectrophotometric determination

Molecular weights determination by gel chromatography

Molecular-weight determination boiling-point elevation

Molecular-weight determination by gel

Molecular-weight determination from electrospray mass spectra

Molecular-weight determination small molecules

Molecular-weight distributions determination

Nitrocellulose molecular weight determination

Nuclear magnetic resonance molecular structure determination

Number-average molecular weights determination

Oligonucleotides molecular mass determination

Optical methods of determining molecular sizes and shapes

Osmotic molecular weight determination

Osmotic molecular weight determination results

Osmotic molecular weight determination theory

Peptides molecular weight determination

Peptides/proteins molecular mass determination

Percentage composition determining molecular formula from

Poly molecular weight determination

Polyamides molecular weight determination

Polycaprolactone molecular weight determination

Polymer molecular-weight distribution, determination

Polymers, molecular-weight determination

Polysaccharides molecular-weight determinations

Potential energy calculations, molecular structure determination

Product oils molecular weight determinations

Protein chromatography molecular weight determination

Protein molecular mass determination

Proteins molecular weight determination

Qualitative Analyses Molecular Structure Determination

Rast molecular weight determination

Rate-determining steps molecularity

Relative molecular mass determination

Sedimentation enzyme molecular-weight determination

Sedimentation equilibrium, determination weight-average molecular weights

Sedimentation velocity molecular weight determination

Size exclusion chromatography determine relative molecular weights

Size exclusion chromatography molecular weight determination

Size, Shape, and Molecular Weight Determinations

Size-exclusion chromatography molecular mass determination

Skill 8.4 Determining empirical and molecular formulas

Sodium alginate molecular weight determination

Spectroscopic Determination of Differential Collision Cross Sections in Crossed Molecular Beams

Starch acetate molecular weight determinations

Structure determination molecular dynamics

Structure, determination of molecular

Temperature influence on molecular weight determination

The Determination of Molecular Dimensions

The Determination of Molecular Weight

The Molecular Weight Determination of Biopolymers

To determine number-average molecular

To determine number-average molecular weight

Using Lewis Structures to Determine Molecular Bonding

Using Standard Molecular Orbital Software to Compute Single Valence Bond Structures or Determinants

Using VSEPR Theory to Determine Molecular Shape

Weights and Molecular Weight Determinations

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