Mini-Pump

Shiromani, P. J. Fishbein, W. (1986). Continuous pontine cholinergic microinfusion via mini-pump induces sustained alterations in rapid eye movement (REM) sleep. Pharmacol. Biochem. Behav. 25, 1253-61. 

Drug solutions and implantation of osmotic mini-pumps Physostigmine hemisulphate and procyclidine hydrochlorid were obtained from Sigma (St.Louis, U.S.A.), scopolamine hydrobromid from Merck (Darmstadt, Germany), atropine sulphate was obtained from ACF (Amsterdam, The Netherlands), and diazepam from Roche (The Netherlands). HI-6 was made available by the Defence Research Establishment, Suffield, Canada. Soman (O-pinacolyl methylphosphonofluoridate) was synthesised at TNO. Alzet Osmotic Mini-pumps with a constant delivery rate of 0.55 pl/hr (Model 2002, Alza Corp., Palo Alto, USA) were used to deliver PYR, PHY and SCO. The vehicle consisted of 20% propylene glycol, 10% ethanol and 70% water. The pumps were implanted subcutaneously under isoflurane/02 inhalation anesthesia. 

In parenteral therapy, the subcutaneously implantable, osmotic mini-pumps developed by the Alza Corp. are used widely in experimental animal studies. The DUROS implant pump is a modified version of the Alzet pumps and was developed specifically for the controlled delivery of peptides and proteins (see Section 4.6.1.2). Osmotic mini-pumps, such as the Oros osmotic pump, are also available for controlled... 

For developing miniaturized chromatographic systems, one possibility is to use a conventional pump with a split-flow device. Although such pumps are enough to ran miniaturized chromatographic systems, their size is very large compared to the system itself. Based on the size of such miniaturized systems, the size of the mini pump should be 25 cm3 or less. However, such small pumps are unavailable presently. 

MA.). The exclusion limit of this column system is 1.7 x 10° determined with polystyrene standards (Waters Assoc., Milford, MA). The HPLC system consists of a piston pump (mini-pump, Milton Roy Co., Hollywood, Fla.), the columns, a Rheodyne injector 7125 an R—U Differential Refractometer, and a Speedomax H recorder (Leeds and Northrop, Phila., PA), with THF as the eluant. 

Pencil, grease or magic marker 1 Pipet, Mohr, 5 mL 1 Pump, Milton Roy, mini-pump 1 Rack, test tube for small tubes 1 Ring, iron, 10 cm 1 Spectrophotometer, uv/vis 1 Sponge... 

The uncertainty associated with this process was dependent on human reflexes. One stroke of the generator pump (Milton Roy Controlled Volume Mini-Pump) is 0.05 mL. If we assume that the volumetric... 

The column has a total height of 5.4 m and a diameter of 2.54 cm. Initially, 450 ml of reactants was charged into the reboiler. A Milton-Roy LCD mini-pump was used to provide a continuous feed to the column. The bottom product flow rate was adjusted so that the liquid level in the reboiler remained constant. The operation was controlled by a conputer system. The details of the pilot plant and the experimental procedure for the operation of the pilot plant have been reported by Poi-ebarac et al. [4]. 

Biological microchips (biochips) are revolutionizing gene expression analysis and classical genotyping as well as diagnostics and testing. Tlie worldwide markets for biochips are primarily composed of DNA chips, protein chips and laboratory chips. Generally, anays are differentiated from microfluidic systems, which can actively operate analysis, separation and synthetic processes by means of microscopic capillary systems, mini-pumps and mini-valves. Tliese are often called a Tab-on-a-chip . 

In the DuPont 848 liquid chromatograph, a special Haskel mini-pump is used, derived from the Haskel Model M. The volume of the cylinder is small (about 2 ml). In the original Haskel Model M pump, the return of the piston is actuated by an air selector valve and a spring, so that the liquid pressure is not constant because the gas piston must compress the spring during its forward stroke. In the modified pump, the spring is replaced with a small counter-pressure. The main characteristics of commercial pneumatic amplifier pumps are summarized in Table I. 

Shahinpoor and Moj aired used ion-exchange materials and membranes to produce electrically responsive actuators [41—48] and also encapsulated ion-exchange membrane sensor/actuators. Shahinpoor used electrically responsive polymers coupled with springs and other mechanical devices to improve upon electrically responsive actuators [52] and ionic polymeric conductor composites and ionic polymer metal composites to drive pumps and mini-pumps [41]. 

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