Duros implant pump

In parenteral therapy, the subcutaneously implantable, osmotic mini-pumps developed by the Alza Corp. are used widely in experimental animal studies. The DUROS implant pump is a modified version of the Alzet pumps and was developed specifically for the controlled delivery of peptides and proteins (see Section 4.6.1.2). Osmotic mini-pumps, such as the Oros osmotic pump, are also available for controlled... 

The Duros implant pump is a modified version of the Alzet miniosmotic pump which additionally contains a piston to control drug flow, between the osmotic engine and the drag resorvoir (Figure 4.18). 

What is the principle that has been utilized in the development of the Alzet and the Duros implant pumps in which a dmg solution or suspension is confined in a semi-permeable membrane that allows only water molecules to move through it ... 

A subcutaneously implantable protein delivery system made up of a DUROS osmotic pump containing dry (lyophilized or spray-dried) protein formulations in nonaqueous suspending vehicle is being developed for long-term release of proteins at the target site. The duration of protein release can be... 

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