Benzyl alcohol 4-methyl

Chemical Name 3,5-dihydroxy-0 -[ [(p-hydroxy-a -methylphenethyl)amino] methyl] benzyl alcohol hydrobromide... 

Wang used method D to fashion a key intermediate for the synthesis of rishirilide B (Fig. 4.20).21 The 2,4-bis-OBoc-3-methyl-benzyl alcohol (31) undergoes the addition of two equivalents of corresponding Grignard reagent to afford phenol 32 in 75% yield (Fig. 4.20). This material was subsequently elaborated by Mejorado in three steps (61% yield) to the corresponding 2,5-chiral cyclohexadienone 33, which was ultimately transformed into ( + )-rishirilide B (34).22... 

Table 4 The effects of a-carbonyl and a-thiocarbonyl substituents on the relative stabilities of a-methyl benzyl alcohols R-[16]-OH and the corresponding styrenes R-[17] (Scheme 13)"...

The reactor effluent is distilled and unreacted EB is recycled. The EB hydroperoxide is then reacted with propylene at 250°F and pressure in the range of 250-700 psi in the presence of a metal catalyst to produce propylene oxide and methylbenzyl alcohol B in Figure 8-7). The reactor mixture is separated by multiple fractionators. Unreacted propylene and EB are recycled. PO is recovered overhead. The methyl benzyl alcohol is easily dehydrated in the vapor stage at 450—500° F and 500 psi pressure over a titanium dioxide or silica gel catalyst to form styrene. Acephenone is one of the by-products. 

Methyl n-amyl carbinol. 247, 254 Methyl n-amyl ketone, 482 Methylaniline (mono), pure, from commercial methylaniline, 562, 570 P-Methylanthraquinone, 728, 740 Methyl benzoate, 780, 781 p-Methyl benzyl alcohol, 811,812 Methyl benzyl ketone, 727, 735 Methyl y-bromocrotonate, 926, 927 2-Methyl-2-butene, 239 Methyl n-butyl carbinol, 247,255 Methyl n-butyl ether, 314 Methyl n-butyl ketone, 475, 481 4-Methylcarbostyril, 855 p-Methylcinnamic acid, 719 4-Methylcoumarin, 853, 854 Methyl crotonate, 926, 927 Methylethylacetic acid, 354, 358 Methylethylethynyl carbinol, 468 Methyl ethyl ketone, 335, 336 purification of, 172 Methyl n-hexyl ether, 314 Methyl n-hexyl ketone, 335, 336 Methyl n-hexyl ketoxime, 348 Methyl hydrogen adipate, 938 Methyl hydrogen sebacate, 938,939 4-Methyl-7-hydroxycoumarin, 834 Methyl iodide, 287 Methyl isopropyl carbinol, 247,255 Methyl 4-keto-octanoate, 936... 

Kinetic and mechanistic investigations on the o-xylene oxidation over V205—Ti02 catalysts were carried out by Vanhove and Blanchard [335, 336] using a flow reactor at 450°C. Possible intermediates like o-methyl-benzyl alcohol, o-xylene-a,a -diol, toluic acid and phthalaldehyde were studied by comparing their oxidation product distribution with that of toluene. Moreover, a competitive oxidation of o-methylbenzyl alcohol and l4C-labelled o-xylene was carried out. The compounds investigated are all very rapidly oxidized, compared with o-xylene, and essentially yield the same products. It is concluded, therefore, that these compounds, or their adsorbed forms may very well be intermediates in the oxidation of o-xylene to phthalic anhydride. The ratio in which the partial oxidation products are formed appears to depend on the nature of the oxidized compounds, i.e. o-methylbenzyl alcohol yields relatively more phthalide, whereas o-xylene-diol produces detectable amounts of phthalan. This... 

FIGURE 22.8 The 200-MHz 1H NMR spectra of (a) 4-methylbenzylamine and ( >) 4-methyl benzyl alcohol. The singlet corresponding to CH2N in (a) is more shielded than that of CH20 in (b). 

Optically active acrylic, chloro-acrylic and methacrylic esters of sec. butyl alcohol, 2-methyl-butyl alcohol, 1.3-dimethyl-butyl alcohol, 1-methyl-benzyl alcohol, bomeol and menthol have been polymerized mostly by radical mechanism (Tables 16, 17, 18). 

U,5-Dihydroxy-2-methoxyphenyl-ethylamine, AP9U 3, U-D i hydroxy-o -[ (methylami no)-methyl]benzyl alcohol, AP92... 

An alternative method for the manufacture of styrene (the oxirane process), uses ethylbenzene that is oxidized to the hydroperoxide and reacts with propylene to give phenylmethylcarbinol (or methyl benzyl alcohol) and propylene oxide. The alcohol is then dehydrated at relatively low temperatures (180 to 400°C) by using an acidic silica gel (Si02) or titanium dioxide (Ti02) catalyst. 

Pd(ll) Kinetic Resolution Cs2C03/t-Bu0H Conditions (-)- -Methyl benzyl Alcohol [6]... 

A preparatively more useful form of this reaction is the crossed Cannizzaro reaction which ensues when a mixture of an aromatic aldehyde and formaldehyde is allowed to react under the influence of strong base (e.g. the preparation of p-methyl benzyl alcohol, Expt 6.134). A substantial proportion of the aromatic aldehyde is reduced to the corresponding alcohol while the formaldehyde is... 

A fruitful approach to obtain asymmetric polymer synthesis was proposed by Overberger (126) who suggested that propagation could be influenced and optically active polymers could be synthesized by using optically active gegen-ions. Schmidt and Schuerch (127) followed up this suggestion and used boron trifluoride in conjunction with asymmetric Lewis bases (1-a-methyl benzyl alcohol, tosyl L-valine, camphor) to polymerize certain cyclic olefins. However, in spite of careful work and various modifications in reaction conditions, no optical activity was obtained in the polymers in this first attempt to test this ingenious hypothesis. 

The electro-Fenton method (or EFR) was initially used for synthetic purposes considering the hydroxylation of aromatics in the cathodic compartment of a divided cell. Thus, the production of phenol from benzene (Tomat and Vecchi 1971 Tzedakis et al. 1989), (methyl)benzaldehydes and (methyl)benzyl alcohols from toluene or polymethylbenzenes (Tomat and Rigo 1976,1979,1984,1985) by adding Fe3+ to generate Fe2+ via reaction (19.13), as well as benzaldehyde and cresol isomers from toluene or acetophenone and ethylphenol isomers from ethylbenzene (Matsue et al. 1981) with direct addition of Fe2+, have been described. Further studies have reported the polyhydroxylation of salicylic acid (Oturan et al. 1992)... 

The initial products are the p-methyl benzyl alcohol and p-methyl benzal-dehyde. Under the reaction conditions these are further oxidized, first to p-toluic acid, and ultimately to terephthalic acid. The alkoxy and peroxy radicals that take part in the oxidation of p-xylene to p-toluic acid are shown by 8.13 to 8.16. 

DIHYDROXY-a-((ISOPROPYL-AMINO)-METHYL)BENZYL ALCOHOL... 

S YN S 1 -a-HYDROXY- 3-xMETHYLAMINO-3-HYDRO-XY-l-ETHYLBENZENE (R)-3-HYDROXY-0-((METHYL-AMINO)METHYL)BENZENEMETHANOL 1-m-HYDROXY-0-((METHYLAMINO)METHYL)-BENZYL ALCOHOL (-)-m-HYDROXY-a-(METHYLAMINO-METHYL)BENZYL ALCOHOL l-l-(m-HYDROXY-PHENYL)-2-METHYLAMINOETHANOL l-(3-HYDROXYPHENYL)-N-METHYLETHANOLAMINE ISOPHRIN MESATON METAOXEDRIN METASYMPATOL METASYNEPHRINE m-METHYLAMINOETHANOLPHENOL MEZATON R(-)-MEZATON tn-OXEDRINE (-)-tn-OXEDRINE PHENYLEPHRINE (-)-PHENYLEPHRINE R(-)-PHENYLEPHRINE m-SYMPATHOL m-SYMPATOL... 

C8H9BrO (2-bromoethoxy)benzene 589-10-6 513.15 45.149 2 13640 C8H9FO 4-ftuoro a-methyl benzyl alcohol 403-41-8 445.88 38.709 2... 

Isopar-H-benzyl alcohol, methyl benzyl alcohol, acetophenone—water 2x12 24 2... 

Quinones et al. have measured equilibrium isotherm data for benzyl alcohol, 2-methyl benzyl alcohol and 2-phenylethanol on a Cig-bonded silica at different temperatures between 20 and 60 °C [129]. The results for benzyl alcohol are shown in Figure 3.34 left. From these isotherms, they derived the Clausius-Clape)non... 

Figure 3.46 Single solute adsorption data at 30°C obtained via FA (points) and FACP (lines). Compounds benzyl alcohol (circles and solid line), phenylethanol (squares and dashed line) and methyl benzyl alcohol (triangles and dashed-dotted Une) Reproduced with permission from I. Quinones, J. C. Ford and G. Guiochon, Chem. Eng. ScL, 55 (2000) 909 (Fig. 4).

Quinones et al. [17] measured by frontal analysis multisolute adsorption equilibrium data for the system benzyl alcohol, 2-phenylethanol and 2-methyl benzyl alcohol in a reversed-phase system. Data were acquired for the pure compoimds, for nine binary mixtures (1 3,1 1, and 3 1) and four ternary mixtures (1 1 3,1 3 1, 3 1 1, and 1 1 1). These data exhibited very good thermod5mamic consistency. The thermodynamic functions of adsorption were derived from the single-solute ad-... 

Figure 4.6 illustrates the use of the IAS model to account for the competitive isotherm data of a ternary mixture of benzyl alcohol (BA), 2-phenylethanol (PE) and 2-methyl benzyl alcohol (MBA) in reversed phase liquid chromatography. The RAS model accounts for the nonideal behaviors in the mobile and the stationary phases through the variation of the activity coefficients with the concentrations. Figures 4.6d and 4.6e illustrate the variations of the activity coefficients in the stationary and the mobile phases, respectively. The solutes exhibit positive deviations from ideal behavior in the adsorbed phase and negative deviations from ideal behavior in the mobile phase. 

Figure 4.6 Competitive isotherms of a ternary mixture of benzyl alcohol (BA), phenyl-2-ethanol (PE) and methyl-benzyl alcohol (MBA) on Cig-sUica with MeOH/H20 as the mobile phase, at different relative concentrations. Adsorbed amormts of (a) benzyl alcohol, (b) 2-phenylethanol, (c) 2-methyl benzyl alcohol, (d) activity coefficient in the mobile phase versus concentration. In Figures (a), (b), (c), the open circles are for equal parts of BA, PE and MBA, the diamonds for three parts of BA, 1 part PE and 1 part MBA), the triangles for one part of BA, one part of PE and three parts of MBA and the stars for the singlecomponent isotherms. The solid line is the Flory-Huggins model and the dashed lines are the IAS model isotherms. In Figures (d) and (e), the circles are for BA, the squares for PE, the triangles for MBA and the diamonds for the solvent. Reproduced from I. Quinones, J. Ford, G. Guiochon, Chem. Eng. Set, 55 (2000) 909 (Figs. 12,13 and 14).

Quinones et al. measured by frontal analysis the single-component, binary and ternary isotherms of benzyl alcohol (BA), 2-phenyl ethanol (PE) and 2-methyl benzyl alcohol (MBA) on Symmetry-Cis, using a binary mobile phase (MeOH HaO... 

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