2- Methylamino-2-methyl

Chemical Name N-(4-([(2,4-Diamino-6-pteridinyl)methyl] methylamino] -benzoyl] -L-glutamic acid... 

CN lV-[[5-[[(l,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]methylamino]-2-thienyl]carbonyl]-L-glutamic acid i... 

Methotrexate Methotrexate, N- p-[[2,4-diamino-6-piperidinyl)methyl]methylamino]-benzoyl]-L-( )-glutamic acid (30.1.1.8), is made by reacting A-(4-methylaminoben-zoyl)glutaminic acid (30.1.1.3) with 2-amino-4-hydroxyl-6-bromomethylpteridine... 

Interestingly, attempts to adapt either Scheme 3.10 or Scheme 3.11 to the preparation of 7-azaMTX (55) were uniformly unsuccessful (Scheme 3.12). In the former case, the alkylation product of methyl / -(methylamino)benzoate [64] with cyanomethyl tosylate was converted to the imino ether (56) as previously described for (46). Reaction of (56) with (47) produced none of the... 

PTERIDINYL)METHYL)METHYLAMINO)BENZOYL) GLUTAMIC ACID see MDV500... 

Mono Q Chromatography - For the purification of recoverin, fractions from the phenyl-Sepharose eluate containing protein are combined and dialyzed against 10 mM l,3-bis[tris(hydroxy-methyl)methylamino]propane (BIT) buffer, pH 8.4 containing 1 mM EDTA. i iquots are applied to a Mono Q column (HR 5 x 50 mm Pharmacia Fine Chemicals) equilibrated with the same buffer. A linear gradient of NaCl (0-0.25M NaCl) in the same buffer is developed over 20 min at a rate of 0.5 ml/min, and recoverin elutes at 125 mM NaCl. Approximately 1 mg of purified recoverin is obtained per fifty retinas. 

Synonyms Anilinomethane Benzenamine, N-methyl- (Methylamino) benzene N-Methylaminobenzene Methylaniline N-Methylbenzenamine Methylphenylamine N-Methylphenylamine Monomethyl aniline N-Monomethylaniline N-Phenylmethylamine Ciassification Aromatic sec. amine Empiricai C7H9N Formuia CeHsNHCHa... 

Example Miller and Rich investigated the conformational consequences of substitution s on an amino acid in cyclosporin A. an importan t iininunosnppressive dnig. One of th e ammo acids iii this cyclic iin decapeptide is (2.v, ir. 4r, 5f )-3-nydroxy-4-methyl-2-(methylamino)-6-octenoic acid (MeBmtli. It is essential for biological activitv. 

Methylamino)-4-methylselenazole was obtained by methylation of the potassium salt of 2-acetamido-4-methylselenazole with methyl iodide, followed by hydrolysis (Scheme 13) (26). 

Miller, KE. Rich, D.H. Molecular Mechanics Calculations of Cyclosporin A Analogues. Effect of Chirality and Degree of Substitution on the Side-Chain Conformations of (2s, 3r, 4r, 6e)-3-Hydroxy-4-methyl-2-(methylamino)-6-octenoic Acid and Related Derivatives. 

Methyl-2-(methylthio)-propanal 0-[(methylamino)-carbonyl] oxime [116-06-3]... 

A Methylamino)phenol. This derivative, also named 4-hydroxy-/V-methy1ani1ine (19), forms needles from benzene which are slightly soluble in ethanol andinsoluble in diethyl ether. Industrial synthesis involves decarboxylation of A/-(4-hydroxyphenyl)glycine [122-87-2] at elevated temperature in such solvents as chlorobenzene—cyclohexanone (184,185). It also can be prepared by the methylation of 4-aminophenol, or from methylamiae [74-89-5] by heating with 4-chlorophenol [106-48-9] and copper sulfate at 135°C in aqueous solution, or with hydroquinone [123-31 -9] 2l. 200—250°C in alcohoHc solution (186). 

The basic piSTa values, which have to be considered as equilibrium values, including those of anhydrous and hydrated species, reveal a destabilizing inductive effect of the 6- and 7-methyl group towards 3,4-hydrate formation, as do also the 2-methylamino and 2-dimethylamino groups for additional steric reasons. If the cation of 2-aminopteridine did not add water its value would be about 1.6, arrived at by substracting from the piSTa 2.6 of the essentially anhydrous 2-amino-4,7-dimethylpteridine cation 0.3 for the 7- and 0.7 for the 4-methyl group. The difference between the observed value of 4.29 and the... 

The alkylthio group is replaceable by nucleophiles. The positions 7 and 4 react under mild conditions in that order the 2-alkylthio functions require more drastic treatment. Conversion of l-methyl-4-methylthiopteridin-2-one (157) into the 4-methylamino derivative (158) can be achieved by stirring with methylamine at room temperature (equation 48). The reactivity of an alkylthio group can often be further enhanced by oxidation to the corresponding sulfoxide and sulfone. Thus, reaction of l,3-dimethyl-7-methylthiolumazine (160) with m-chloroperbenzoic acid yields 7-methylsulfinyl- (161) and 7-methylsulfonyl-l,3-dimethyllumazine (162 equation 49) (82UP21601). 4-Amino-2-methylthio-7-... 

Isoxazolo[5,4-d]pyrimidine, 4-hydroxy-3-methyl-UV, 6, 620 <64JOC2116) Isoxazolo[5,4-d]pyrimidine, 3-methyl-4-(methylamino)-UV, 6, 620 <64JOC2116) Isoxazolo[5,4-d]pyrimidine, 3-phenyl- H NMR, 6, 619 <77H(7)51) Isoxazolo[3,4-d]pyrimidine-4,6(5//,7W)-dione, 5,7-dimethyl-... 

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