Lymph nodes, mesenteric

Jang MH, Sougawa N, Tanaka T, et al. CCR7 is critically important for migration of dendritic cells in intestinal lamina propria to mesenteric lymph nodes. J Immunol 2006 176(2) 803-810. 

Koyama, K., Tamauchi, H., Tomita, M., Kitajima, T. and Ito, Y. (1999) B cell activation in the mesenteric lymph nodes of resistant BALB/c mice infected with the murine nematode parasite Trichuris muris. Parasitology Research 85, 194—199. 

Bacterial translocation is defined as the passage of viable indigenous bacteria from the GI tract to extraintesti-nal sites, such as the mesenteric lymph node complex, liver, spleen and bloodstream [183], Three major mechanisms promote bacterial translocation intestinal bacterial overgrowth, deficiencies in host immune defenses and increased permeability or damage to the intestinal mucosal barrier [184], These mechanisms can act in concert to promote synergistically the systemic spread of indigenous translocating bacteria to cause lethal sepsis. 

Investigations performed in rats with experimental acute pancreatitis [196] or ulcerative colitis [197] have shown that both rectal and oral administration of rifaximin decreased colonic bacterial translocation towards mesenteric lymph nodes. In the model of ANP [196] not only was the intra-abdominal spread of enteric bacteria (fig. 8) significantly reduced but also the pancreatic damage was lessened by rifaximin treatment. 

Runyon BA, Squier SU, Borzio M Transloca-tion of gut bacteria in rats with cirrhosis to mesenteric lymph nodes partially explains the pathogenesis of spontaneous bacterial peritonitis. J Hepatol 1994 21 792-796. 

Except for lymphopenia, which was observed at all dose levels, no other effects were measured in the 100 and 300 mg/kg groups. At 900 mg/kg, significant decreases occurred in body weight, food intake, blood lymphocytes, and thymus weight, and significant increases occurred in thyroid weight, mesenteric lymph nodes, and histopathology (Vos etal. 1983)... 

Fed 10, 50, 250, or 1250 mg/kg feed for 2 years Increased mortality, reduced growth, disrupted enzyme activity at 1250 mg/kg. Nonneoplastic microgranulomas in lymph, liver, and spleen of 250 and 1250 mg/kg male mice less severe microgranulatomous changes in mesenteric lymph node of 50 and 250 mg/kg groups no observable effect at 10 mg/kg diet 34... 

S,aS isomer Residues were 511 in fat, 45 in mesenteric lymph node, and <22 in other tissues 11... 

S,aR isomer Fat contained 326, mesenteric lymph node 68, and other tissues <20 11... 

R,aR isomer Fat contained 756, in mesenteric lymph node 94, and other tissues <23 11... 

Sibley, D.A., Fuseler, J., Slukvin, I., and Jerrells, T.R., Ethanol-induced depletion of lymphocytes from the mesenteric lymph nodes of C57B1/6 mice is associated with RNA but not DNA degradation, Alcohol Clin. Exp. Res., 19, 324, 1995. 

Information on immunological/lymphoreticular effects in test animals is limited to histopathological examination of tissues after intermediate-duration inhalation exposure to -hexane. No treatment-related lesions were observed in the cervical, bronchial, or mesenteric lymph nodes, thymus, bone marrow (sternum), or spleen of male Sprague-Dawley rats exposed to 500 ppm -hexane 22 hours a day for 6 months (IRDC 1981) or in mandibular and mesenteric lymph nodes, thymus, bone marrow, or spleen of Fischer 344 rats of both sexes exposed to up to 10,000 ppm for 6 hours a day, 5 days a week for 13 weeks (Cavender et al. 1984). Similar results were observed in mesenteric lymph nodes, thymus, bone marrow (sternum), and spleen in B6C3Fj mice exposed to -hexane at concentrations up to 10,000 ppm for 6 hours a day, 5 days a week for 13 weeks or 1,000 ppm for 22 hours a day, 5 days a week for 13 weeks (Dunnick et al. 1989 NTP 1991). 

Cervical lymph node Mesenteric lymph node Thymus... 

Fecal softeners are substances that are not absorbed from the alimentary canal and act by increasing the bulk of the feces and softening the stool so that it is easier to pass. Mineral oil has been in use for many years, either as the oil or as a white emulsion it is a mixture of liquid hydrocarbons. Its use has been criticized for many reasons. It dissolves the fat-soluble vitamins and prevents their absorption. It is itself absorbed slightly and appears in the mesenteric lymph nodes, and if it is... 

Mitochondrial ATPase inhibition. Smoke extract, in the mouse brain mitochondria culture in the presence or absence of vitamin C for 60 minutes, inhibited mitochondrial ATPase and cytochrome C oxidase activities in a dose-dependent manner. The effect of extract on mitochondria swelling response to calcium stimulation was dependent on calcium concentrations. The extract treatment induced mitochondrial inner membrane damage and vacuolization of the matrix, whereas the outer mitochondrial membrane was preserved. Nicotine produced no significant damage . Mitogenic activity. Water extract of the dried leaf, administered to mice at a concentration of 0.05%, was active on lymphocytes from mesenteric lymph node and lymphocytes B and T. Intracellular Ca level was unchanged. The extract was active on... 

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