Melanoma biopsy

For patients with melanomas that are at risk of spreading to the lymph nodes, a sentinel lymph node (SLN) biopsy is performed. The SLN, the first lymph node to receive lymph draining from the tumor, is identified by injecting a radioactive material, technetium-99m-labeled radiocolloids, and vital... 

Melanoma Thickness Margin of Excision Sentinel Lymph Node Biopsy... 

Figure 13.1 (a) and (b) showing an endobronchial ultrasound (EBUS)-FNA biopsy of an enlarged mediastinal lymph node from a 63-year-old male with a left lower lobe lung mass and a remote history of melanoma. (See text for full caption). 

Based on these findings and toxicology studies [233], human clinical phase I studies have been initiated [234]. In tumor biopsies from melanoma patients obtained after treatment, a reduction was found in both the specific mRNA (M2 subunit of ribonucleotide reductase, RRM2) and in the protein (RRM2) levels when compared to pre-dosed tissue. The presence of an mRNA fragment that... 

A 5-year-old boy has a rough, raised lesion on his neck. Physical examination shows that he has excessive freckling and some erythema (redness) of his face, lips, neck, and upper extremities as well as some clouding of his corneas. His mother reports that he has a tendency to sunburn easily and has an aversion to direct sunlight. Pathologic evaluation of a biopsy of the lesion reveals it to be a malignant melanoma. 

Fig. 7.14 Liver biopsy specimens I. in fatty liver (pale yellow), II. in a metastasis of a malignant melanoma (greenish-black)...

Proteinuria with minimal-change nephrotic syndrome on renal biopsy has been attributed to interferon beta in a 64-year-old man with malignant melanoma (45). Although the proteinuria abated after withdrawal, the potential role of previous chemotherapy cannot be excluded. 

Tfalyli, A., Piot, 0., Durlach, A., Bernard, P. and Manfait, M. (2005) Discriminating nevus and melanoma on paraffin-embedded skin biopsies using FT-IR microspectroscopy. Biochim. Eiophys. 

Sentinel" Lymph Node Biopsies for Metastatic Melanoma 196... 

SENTINEL LYMPH NODE BIOPSIES FOR METASTATIC MELANOMA ... 

Medalie N, Ackerman AB. Sentinel lymph node biopsy has no benefit for patients with primary cutaneous melanoma an assertion based on comprehensive, critical analysis. 2nd ed. New York Ardor Scribendi Press 2004 1-95. 

This mitochondrial peroxisome enzyme, alpha-meth-ylacyl-CoA racemase (AMACR) (encoded by the gene P504S) catalyzes the racemization of alpha-methyl branched carboxylic coenzyme A thioesters and is present in prostate tissue and a wide variety of carcinomas (colorectal, ovarian, breast, bladder, lung, renal cell), melanoma, and lymphoma.AMACR is useful in prostate needle biopsies when the differential diagnosis... 

Melvin (Mel) Anoma is a 46-year-old man who noted a superficial, brownish-black, 5-mm nodule with irregular borders in the skin on his chest. He was scheduled for outpatient surgery, at which time a wide excision biopsy was performed. (In an excision biopsy, the complete mole is removed and biopsy performed). Examination of the nodule indicated histologic changes characteristic of a malignant melanoma reaching a thickness of only 0.7 mm from the skin surface (Stage I). 

Mel Anoma. The average person has 20 moles on the body surface ] however, only seven people of every 100,000 develop a malignant melanoma. The incidence of malignant melanoma, however, is rising rapidly. Because 35 to 40% of patients with malignant melanoma die as a result of this cancer, the physician s decision to perform a biopsy on a pigmented mole with an irregular border and variation of color probably saved Mel Anoma s life. 

Mel Anoma returned to his physician after observing a brownish-black irregular mole on his forearm (see Chapter 13). His physician thought the mole looked suspiciously like a malignant melanoma, and performed an excision biopsy (surgical removal for the purposes of biopsy). 

Gutzmer, R., Kaspari, M., Broderson, (.P. et al. (2002) Specificity of tyrosinase and HMB45 PCR in the detection of melanoma metastases in sentinel lymph node biopsies. Histopathology, 41, 510-518. 

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