Histological changes

Imayama S, Ueda S, Isoda M (2000) Histologic changes in the skin of hairless mice following peel-... 

Inhalation of trichloroethylene for acute or intermediate periods can cause liver enlargement in laboratory animals. Usually this effeet is reversible when exposure eeases. Histological changes were observed in some studies but not in others. Liver weight and plasma butyryleholinesterase (BuChE) aetivity were increased in various strains of mice exposed to 37-300 ppm eontinuously for 30 days (Kjellstrand et al. 1983a, 1983b). 

Manley (1936, 1943) reported that major histological changes occurred in the pulp 24 hours after placing a silicate restoration, a finding confirmed by other workers (Zander, 1946 Brannstrom Nyborg, 1960 Stanley, Swerdlow Buonocore, 1967 Qvist, 1975). The silicate cement also inflames the gingiva (gum tissues) (Larato, 1971 Trivedi Talim, 1973) and demineralizes both dentine and enamel (Grieve, 1974). 

Acquatella, H., Gonzales, M.P., Morales, J.H. and Wittem-bury, G. (1972). Ionic and histologic changes in the kidney after perfusion and storage for transplantation. Transplantation 14, 480-489. 

Smith T.D., Siegel M.I., Burrows A.M., Mooney M.P., et al. (1999). Histological changes in the fetal human vomeronasal epithelium during volumetric growth of the vomeronasal organ. In Advances in Chemical Signals in Vertebrates (Johnston R.E., Miiller-Schwarze D. and Sorenson P., eds.). Plenum, New York, pp. 583-592. 

Histological changes in the spleen related to diisopropyl methylphosphonate intake were not observed in male or female rats exposed to 1 mg/kg/day of diisopropyl methylphosphonate in their drinking water for 26 weeks (Army 1978). As discussed in Section 2.2.2.1, there is some confusion concerning the concentration units and purity of the diisopropyl methylphosphonate used in the Army (1978) study (EPA 1989), and therefore results from the Army (1978) study are considered inappropriate for human health risk assessment. No changes in spleen weight were noted in male or female mink exposed to... 

A mixed isomer preparation of TCP (containing <0.1% tri-ort/zo-cresyl phosphate) produced histological changes in reproductive organs in both sexes of rats and female mice in 13-week and 2-year bioassays (NTP 1994). Ovarian interstitial cell hypertrophy occurred in female mice and female rats exposed to gavage doses of 50-800 mg/kg/day for 13 weeks, in female rats exposed to dietary doses of 65 and 120 ng/kg/day for 13 weeks, and in female rats exposed to dietary doses of 9 or 18 mg/kg/day for 2 years (NTP 1994). Atrophy of the seminiferous tubules occurred in male rats that received gavage doses of 400 and 800 mg/kg/day for 13 weeks and in male rats exposed to dietary doses of 470 and 940 mg/kg/day for 13 weeks (NTP 1994). 

A5. Anderson, C. M., Histological changes in the duodenal mucosa in coeliac disease. Reversibility during treatment with a wheat gluten free diet. Arch. Diseases Childhood 35, 419-427 (1900). 

These values are supported by the results of subchronic studies with squirrel monkeys and dogs (Jones et al. 1972). Monkeys and dogs exposed continuously at approximately 15 ppm for 90 d showed no overt clinical signs systemic toxicity consisted of biochemical and/or non-life-threatening histological changes in the liver, spleen, and kidneys. 

Ali SS, Shakoori R. 1993. Short-term toxicity of endrin in Sprague Dawley rats Biochemical and histological changes in liver. Punjab Univ J Zool 8 1-13. 

An MRL of 0.4 mg/kg/day has been derived for intermediate-duration oral exposure to di-/ -octylphthalate. This MRL is based on a NOAEL of 40.8 mg/kg/day for liver effects that were observed in rats fed di-w-octylphthalate in the diet at a dose of 350.1 mg/kg/day (males) or 402.9 mg/kg/day (females) (Poon et al. 1995). These hepatic effects consisted of a statistically significant (p<0.05) increase in hepatic ethoxyresorufin-0-deethylase activity and histological changes in hepatic architecture, including accentuation of zonation and perivenous cytoplasmic vacuolation. Thyroid toxicity (decreased colloid density and reduced follicle size) was also noted at this concentration. The NOAEL was divided by an uncertainty factor of 100 (10 for extrapolation from animals to humans and 10 for human variability). Support for the use of hepatic toxicity as the basis of the intermediate MRL is provided by other studies that show necrosis and other fatty changes after acute- and intermediate-duration exposure of rats (DeAngelo et al. 1986 Lake et al. 1984, 1986 ... 

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