Sentinel lymph node biopsy

Local therapy of early-stage breast cancer consists of modified radical mastectomy or lumpectomy plus external-beam radiation therapy. The surgical approach to the ipsilateral axilla may consist of a full level I/II axillary lymph node dissection or a lymph node mapping procedure with sentinel lymph node biopsy. 

Melanoma Thickness Margin of Excision Sentinel Lymph Node Biopsy... 

Axillary lymph nodes should be sampled for staging and prognostic information. Lymphatic mapping with sentinel lymph node biopsy is a new, less invasive alternative to axillary dissection however, the procedure is controversial because of the lack of long-term data. 

Sentinel" Lymph Node Biopsies for Metastatic Melanoma 196... 

SENTINEL LYMPH NODE BIOPSIES FOR METASTATIC MELANOMA ... 

Wick MR. Principles of evidence-based medicine as applied to sentinel lymph node biopsies. Pathol Case Rev. 2008 13 102-108. 

Medalie N, Ackerman AB. Sentinel lymph node biopsy has no benefit for patients with primary cutaneous melanoma an assertion based on comprehensive, critical analysis. 2nd ed. New York Ardor Scribendi Press 2004 1-95. 

Bass SS, Lyman GH, McGann GR, et al. Lymphatic mapping and sentinel lymph node biopsy. Breast J. 1999 5 288-295. 

Gzerniecki BJ, Scheff AM, Callans LS, et al. Immunohistochemistry with pancytokeratins improves the sensitivity of sentinel lymph node biopsy in patients with breast carcinoma. Cancer. 1999 85 1098-1103. 

Gutzmer, R., Kaspari, M., Broderson, (.P. et al. (2002) Specificity of tyrosinase and HMB45 PCR in the detection of melanoma metastases in sentinel lymph node biopsies. Histopathology, 41, 510-518. 

Marchiole P, Buenerd A, Scoazec JY, Dargent D, Mathevet P (2004) Sentinel lymph node biopsy is not accurate in predicting lymph node status for patients with cervical carcinoma. Cancer 100 2154-2159... 

Fig. 7.22 Chemical structures of dyes used for sentinel blue. The latter dye is not tilways approved for sentinel lymph node biopsies—the tiiarylmethane dyes, patent lymph node localization blue V and isosulfan blue, and the thiazine dye, methylene...

Studies in which isosulfan was used for sentinel lymph node biopsies in breast and melanoma patients showed allergic reactions in 1.42 % of patients. With regard to the severe allergic reactions (grade III), the figures were 0.44 % and 0.06 % for isosulfan blue and patent blue V, respectively. 

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