Minimal change nephrotic syndrom

Ovarian adenocarcinoma, Breast carcinoma, Hodyhin s disease, non-Hodgkin s lymphoma, multiple myeloma, leukemia (acute lymphoblastic, acute myelogenous, acute monocytic, chronic granulocytic, chronic lymphocytic), mycosis fungoides, disseminated neuroblastoma, retinoblastoma PO 1-5 mg/kg/day. IV 40-50 mg/kg in divided doses over 2-5 days or 10-15 mg/kg every 7-10 days or 3-5 mg/kg twice a week. Biopsy-proven minimal-change nephrotic syndrome PO 2 5-3 mg/kg/day for 60-90 days. 

L2. Lee, D. Y., Kim, W., and Kang, S. K., Angiotensin-converting enzyme gene polymorphism in patients with minimal-change nephrotic syndrome and focal segmental glomerulosclerosis. Nephron 77,471-473 (1997). 

In 54 patients, a kidney biopsy was performed 13.2 8.9 days after onset (n = 32). In all patients, the findings suggested either acute tubular necrosis or its recovery phase. The underlying diseases included kidney diseases such as IgA nephropathy [138], minimal change nephrotic syndrome [139], autosomal dominant polycystic kidney disease (ADPKD) [140], and cystinuria [67]. 

Ishii H, Ishikawa I, Masuzaki S, Sugishita N, Tateishi K, Kitada H, Yuri T, Shinode A (1989) A case of exercise-induced acute renal failure developed during the remission of minimal change nephrotic syndrome (Japanese abstract). Nippon Jinzo Gakkai Shi (Jpn J Nephrol) 30 1326-1327... 

There has been a report of minimal-change nephrotic syndrome (41) in temporal relation to influenza vaccine. 

Kielstein JT, Termuhlen L, Sohn J, Khem V. Minimal change nephrotic syndrome in a 65-year-old patient following influenza vaccination. Clin Nephrol 2000 54(3) 246-8. 

A 57-year-old woman developed severe nephrotic syndrome after 3 months of interferon alfa re-treatment, and renal biopsy showed minimal change nephrotic syndrome with T cell-predominant interstitial nephritis (265). Proteinuria persisted despite interferon alfa withdrawal and resolved only after glucocorticoid treatment. 

Proteinuria with minimal-change nephrotic syndrome on renal biopsy has been attributed to interferon beta in a 64-year-old man with malignant melanoma (45). Although the proteinuria abated after withdrawal, the potential role of previous chemotherapy cannot be excluded. 

Nakao K, Sugiyama H, Makino E, Matsuura H, Ohmoto A, Sugimoto T, Ichikawa H, Wada J, Yamasaki Y, Makino H. Minimal change nephrotic syndrome developing during postoperative interferon-beta therapy for malignant melanoma. Nephron 2002 90(4) 498-500. 

Dharnidharka VR, Rosen S, Somers MJ. Acute interstitial nephritis presenting as presumed minimal change nephrotic syndrome. Pediatr Nephrol 1998 12(7) 576-8. 

Clasen W, Kindler J, Mihatsch MJ, Sieberth HG. Long-term treatment of minimal-change nephrotic syndrome with cyclosporin a control biopsy study. Nephrol Dial Transplant 1988 3 733-737. 

Kranz B, Vester U, Buscher R, Wingen AM, Hoyer PF. Cyclosporine-A-induced nephrotoxicity in children with minimal-change nephrotic syndrome long-term treatment up to 10 years. Pediatr Nephrol 2008 23 581-586. 

Interferon-a Recombinant IFN-a -Viral hepatitis - Non-Hodgkin lymphoma - Several other malignancies - Acute renal failure - Proteinuria - Lupus-like disease -Pauci-immuneGN -RPGN -FSGS - Minimal change nephrotic syndrome -Allograft rejection 27,31,32, 33-35, 38-40, 42-48,51,52, 54, 58,59... 

Nolasco F, Cameron JS, Heywood EE, et al. Adult-onset minimal-change nephrotic syndrome A long-term follow-up. Kidney Int 1986 29 1215-1223. 

A report of the International Study of Kidney Disease in Children The primary nephrotic syndrome in children. Identification of patients with minimal change nephrotic syndrome for initial response to prednisone. JPediatr 1981 98 561-564. 

Cho BS, Yoon SR, Jang JY, Pyun KFI, Lee CE. Up-regulation of interleukin-4 and CD23/FcepsilonRII in minimal change nephrotic syndrome. Pediatr Nephrol 1999 13 199-204. 

Ittel TFI, Clasen W, Fuhs M, Kindler J, Mihatsch MJ, Sieberth FIG. Long-term dclosporine A treatment in adults with minimal change nephrotic syndrome or focal segmental glomerulosclerosis. Clin Nephrol 1995 44 156-162. 

Ikeda, M., et al., Reversible posterior leukoencephalopathy in a patient with minimal-change nephrotic syndrome. Am J Kidney Dis, 2001. 37(4) p. E30. 

Gastrointestinal A child with refractory minimal-change nephrotic syndrome developed severe immune-mediated ulcerative colitis 42 days after rituximab therapy [157- ]. 

In 18 patients with minimal change nephrotic syndrome or IgA nephropathy taking ciclosporin, tubular expression of Toll-like receptors was increased, as were TLR4 mRNA and protein expression in a dose-related fashion [11 ]. 

Sato T, Kawasaki Y, Waragai T, Imaizumi T, Ono A, SakaiN, et al. Relapse of minimal change nephrotic syndrome after intravitreal bevad-zumab. Pediatr Int 2013 55(3) e46-8. 

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