Medicine and biochemical research

Uses Medicine and biochemical research inhibits HL-60 cell growth by induction of apoptosis... 

Yinon J, Laschever M. 1982. Direct-injection chemical ionization mass spectrometry of explosives in water. European Journal of Mass Spectrometry in Biochemical, Medicine, and Environmental Research 2 101-104. 

Department of Host Defense and Biochemical Research, Juntendo University, Graduate School of Medicine, Tokyo, Japan (337)... 

For twenty years localised MRS has been used in medicine and biomedical research to obtain non-invasive biochemical information from living tissue (Koretsky et al. 1992). The spectra obtained possess the very valuable property that the intensity of a given peak is proportional to the number of nuclei contribut-... 

G. Lhoest, J. H. Poupaert, and M. Claesen, European J. Mass Spectrometry in Biochemical, Medicine and Environmental Research, 1,57 (1980). 

Monica Bari Department of Experimental Medicine and Biochemical Sciences, University of Rome, Tor Vergata, Rome, Italy Robert I. Block Department of Anesthesia, University of Iowa, Iowa City, lA Karen Bolla Molecular Neuropsychiatry Branch, Intramural Research Program, National Institute on Drug Abuse-National Institutes of Health, Baltimore, MD... 

Of about 2 000 known enzymes, about 150 are commercially produced in milligram-to-kilogram quantities for use in medicine, analysis, and biochemical research. Only 17 enzymes are used in industry, and these are mostly hydrolases (Table 30-10). 

Chemical and biochemical studies on antioxidant components of ginseng. Advances in Chinese medicinal materials research H. M. Chang, H. W. Yeung, W. W. Tso, and A. Koo (eds.). World Scientific Press Philadelphia, PA, 1984 pp. 485-498. 

Research articles of interest to biochemists may appear in many types of research journals. Research libraries do not have the funds necessary to subscribe to every journal, nor do scientists have the time to survey every current journal copy for articles of interest. Two publications that help scientists to keep up with published articles are Chemical Titles (published every 2 weeks by the American Chemical Society) and the weekly Current Contents available in hard copy and computer disks (published by the Institute of Science Information). The Life Science edition of Current Contents is the most useful for biochemists. The computer revolution has reached into the chemical and biochemical literature, and most college and university libraries now subscribe to computer bibliographic search services. One such service is STN International, the scientific and technical information network. This on-line system allows direct access to some of the world s largest scientific databases. The STN databases of most value to life scientists include BIOSIS Pre-views/RN (produced by Bio Sciences Information Service covers original research reports, reviews, and U.S. patents in biology and biomedicine), CA (produced by Chemical Abstracts service covers research reports in all areas of chemistry), MEDLINE, and MEDLARS (produced by the U.S. National Library of Medicine and Index Medicus, respectively cover all areas of biomedicine). These networks provide on-line service and their databases can be accessed from personal computers in the office, laboratory, or library. Some... 

Fig. 9.1 The structure of lipopolysaccharide, LPS. LPS consists of an O-specific antigen, a core oligosaccharide and the lipid A moiety. The core oligosaccharide, which varies from one bacterial species to another, is made up of outer and inner sugar regions. Lipid A virtually always includes two glucosamine residues modified by phosphates and a variable number of fatty acid chains (Frecer et al., 2000). The LPS structure was kindly contributed by Professor Helmut Brade (Research Center Borstel, Leibniz-Center for Medicine and Biosciences, Medical and Biochemical Mikrobiology Parkallee 22, D-23845 Borstel, Germany)...

The isolation of therapeutically active compounds from metabolic products of fungi is no longer regarded as an extraordinary event. Antibiotics constitute excellent examples of the results produced by modern biochemical research. The fungus ergot has been employed in medicine for centuries, and the quest for its active principles commenced nearly 150 years ago. 

Artemisinin is used here as an example of a plant sesquiterpenoid with both traditional value as well as with medicinal and social value in the twenty-first century. Research on artemisinin has also established new benchmarks for biochemical engineering and functional genomics of plant terpenoids. Artemisinin is a functionalized sesquiterpene with a unique peroxide linkage from the sweet wormwood Artemisia annua). Chinese herbalists have used it since ancient times, and it is now used for its unique efficacy to treat multidrug-resistant strains of the malaria parasite Plasmodium falciparum. Its medicinal importance has prompted studies into its biosynthesis and its biochemical engineering so that cost-effective methods for producing it in large scale and in consistent quality may be realized. 

Kailash C. Agarwal, Ph.D., Professor of Molecular and Biochemical Pharmacology. During the past 30 years at Brown University, he has contributed extensively in the development of antithrombotic and cardiovascular drugs both from synthetic sources and medicinal plants. Dr. Agarwal has given many invited lectures both nationally and internationally in his field of research, and he is an active member of several national and international scientific societies. 

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