Medicinal and pharmaceutical research

This Volume of the Handbook of Nuclear Chemistry reflects the state-of-the-art of radiopharmaceutical chemistry and its own intellectual, apparative, methodological, and logistical structure. With deep routes in basic nuclear chemistry, a solid tribe in hot atom and radio chemistry, with many fruitful trees in radiopharmaceutical chemistry, there are, finally, beautiful leaves and flowers in nuclear medicine and pharmaceutical research. Radiopharmaceutical chemistry is ready today to meet the requirements and challenges of modern life sciences. It will thus continuously contribute to the progress in the understanding of the molecular function of the human body, to the development of new drugs, and will provide in parallel a very strong benefit for patient care. 

Dansereau, R. J., Dansereau, R. N., McRorie, f. W., Scintigraphic study of oesophageal transit and retention, in Nuclear Medicine in Pharmaceutical Research. Perkins, A. C., Frier, M. (eds), Taylor Francis, London, 1999, pp. 57-69. 

This drug has had a disastrous medical history due to its teratogenicity, however, its recently found efficacy toward so-called incurable diseases, such as leprosy, AIDS, and various cancers, has revived researchers interest, in particular for the production of optically pure isomers. From this point of view, this article may be attractive to medicinal and pharmaceutical chemists, and also heterocyclic and synthetic chemists. 

The books provide statistical support for professionals and research workers across a range of employment fields and research environments. Subject areas covered include medicine and pharmaceutics industry, finance and commerce public services the earth and environmental sciences, and so on. 

Perkins, A.C. Nuclear Medicine in Pharmaceutical Research Perkins, A.C., Frier, Eds. Taylor and Francis Philadelphia, PA, 1999 15-30. 

Lin, J. H., Ostovic, D. and Vacca, J. P. The integration of medicinal chemistry, drug metabolism and pharmaceutical research and development in drug discovery and development story of Crixivan, an HIV protease inhibitor, Pharm. Biotechnol. Integration of Pharmaceutical Discovery and Development, 11 233-255. 1998. 

The accidental discovery of penicillin in 1928 by Alexander Fleming and its introduction in 1941/42 as an efficient antibacterial drugbearingno substantial side effects revolutionized medicinal chemistry and pharmaceutical research by stimulating completely new strategies in industrial drug discovery. Penicillin... 

There is little doubt that the task of discovering new therapeutic agents that work potently, specifically, and without side effects has become increasingly important and coincidentally more difficult. Advances in medical research that have provided new clues to the previously obscured etiologies of diseases have revealed new opportunities for therapeutic intervention. This has forced the science of medicinal chemistry, once founded almost solely in near-blind synthesis and screening for in vivo effects, to become keenly aware of biochemical mechanisms as an intimate part cf the development process. Even with these major advances in the medicinal and pharmaceutical sciences, more fundamental questions remain. What determines a useful biological... 

The sources of infrared spectra are quite numerous, some of which contain specific information on drugs and pharmaceuticals and others which have data on compounds indirectly related to them. Sadtler Research Laboratories, Inc. (1969) have compiled collections of pharmaceutical, steroid, and biochemical spectra. The pharmaceutical collection contains 850 infrared and 1500 ultraviolet reference spectra of drugs, medicinals, and pharmaceutical compounds compiled from the latest editions of the U.S.P., British Pharmacopeia, International Pharmacopeia, National Formulary, and New and Nonofficial Drugs. The steroid collection contains the infrared spectra of 750 steroids and related compounds. The biochemical collection consists of 2(X)0 infrared spectra and 650 ultraviolet spectra. The American Petroleum Institute and the Manufacturing Chemists Association also have collections of spectra available. (The address is given in the References to this Chapter.)... 

Research Institute for Medicine and Pharmaceutical Sciences University of Lisbon Lisbon, Portugal... 

The six parties that are the founding members of ICH and directly involved in the decision-making process represent the regulatory bodies and the research-based industry in the European Union, Japan, and the USA, the three regions where the majority of new drugs are developed. They are the Committee for Proprietary Medicinal Products of the European Agency for the Evaluation of Medicinal Products and the European Federation of Pharmaceutical Industries and Associations in the EU, the Ministry of Health, Labour and Welfare and Japan Pharmaceutical Manufacturers Association in Japan, the Food and Drug Administration and Pharmaceutical Research and Manufacturers of America in the USA. 

Perkins A and Frier M (eds.) (1999) Nuclear Medicine in Pharmaceutical Research. London Taylor c Francis. 

Medicine and Pharmaceuticals. Applied mathematics, particularly the use of Fourier analysis and wavelet theory, has sparked explosive growth in the fields of medicine and pharmaceutical development. The enhanced analytical methods available to chemists and bioresearchers through NMR and Fourier transform infrared (FTIR) spectroscopy feciUtate the identification and investigation of new compounds that have potential pharmaceutical applications. In addition, advanced statistical methods, computer modeling, and epidemiological studies provide the foundation for unprecedented levels of research. 

Research Institute for Medicines and Pharmaceutical Sciences (iMed.UL), Universidade de Lisboa, Lisboa, Portugal... 

Pimm, M. V., 1999, Scintigraphic study of drug carriers and conjugates. In Nuclear Medicine in Pharmaceutical Research. A. C. Perkins and M. Frier, eds. Taylor and Francis London, ppl33-169. 

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